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1.发明授权
公开(公告)号：US5762943A
公开(公告)日：1998-06-09
申请号：US645672
申请日：1996-05-14
IPC分类号： A61K39/395 , A61K31/00 , A61K31/715 , A61K35/64 , A61K36/00 , A61K38/17 , A61K39/00 , A61K39/35 , A61P37/00 , A61P37/08 , A61K45/00 , A61K39/02
CPC分类号： A61K31/7024 , A61K38/1709 , A61K39/35 , A61K2039/55572
摘要： Methods and compositions for treating type I immunoglobin E (IgE)-dependent hypersensitivity by the administration of monophosphoryl lipid A (MLA) or 3-deacylated monophosphoryl lipid A (3D-MLA) are disclosed. MLA or 3D-MLA administered alone or in combination with an allergen to a patient suffering from type I hypersensitivity reduces levels of total or allergen specific IgE and increases levels of IgG antibody in that patient. MLA and 3D-MLA can be administered as part of a desensitization regimen or as a component of a prophylactic vaccine to prevent a type I hypersensitivity reaction.
摘要翻译： 公开了通过施用单磷酰脂质A（MLA）或3-脱酰基单磷酰脂质A（3D-MLA）来治疗I型免疫球蛋白E（IgE）依赖性超敏反应的方法和组合物。 MLA或3D-MLA单独或与过敏原组合给患有I型超敏反应的患者可降低总体或变应原特异性IgE的水平，并增加该患者的IgG抗体水平。 可以将MLA和3D-MLA作为脱敏方案的一部分或作为预防性I型超敏反应的预防性疫苗的组分进行施用。
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2.发明授权公开(公告)号：US07902159B2
公开(公告)日：2011-03-08
申请号：US11732987
申请日：2007-04-04
申请人： David H. Persing , Richard Thomas Crane , Gary T. Elliot , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Rong Wang
发明人： David H. Persing , Richard Thomas Crane , Gary T. Elliot , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Rong Wang
IPC分类号： A61K31/7008
CPC分类号： C07H13/04 , A61K31/7008 , A61K31/7024 , C07H11/00 , C07H13/06 , C07H15/14
摘要： Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
摘要翻译： 提供了治疗或改善疾病和其他病症如感染性疾病，自身免疫疾病和过敏症的方法和组合物。 该方法使用基于单糖和二糖的化合物来选择性地刺激动物和植物中的免疫应答。
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3.发明授权公开(公告)号：US08318697B2
公开(公告)日：2012-11-27
申请号：US13042312
申请日：2011-03-07
申请人： David H. Persing , Richard Thomas Crane , Gary T. Elliott , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Rong Wang
发明人： David H. Persing , Richard Thomas Crane , Gary T. Elliott , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Rong Wang
IPC分类号： A61K31/7008 , A61K31/7012
CPC分类号： C07H13/04 , A61K31/7008 , A61K31/7024 , C07H11/00 , C07H13/06 , C07H15/14
摘要： Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
摘要翻译： 提供了治疗或改善疾病和其他病症如感染性疾病，自身免疫疾病和过敏症的方法和组合物。 该方法使用基于单糖和二糖的化合物来选择性地刺激动物和植物中的免疫应答。
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4.发明申请PROPHYLACTIC AND THERAPEUTIC TREATMENT OF INFECTIOUS AND OTHER DISEASES WITH MONO- AND DISACCHARIDE-BASED COMPOUNDS 有权感染和治疗单核细胞和基于二磷酸酯的化合物的感染和其他疾病的预防和治疗公开(公告)号：US20110178034A1
公开(公告)日：2011-07-21
申请号：US13042312
申请日：2011-03-07
申请人： David H. Persing , Richard T. Crane , Gary T. Elliot , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Rong Wang
发明人： David H. Persing , Richard T. Crane , Gary T. Elliot , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Rong Wang
IPC分类号： A61K31/7028 , A61K31/7032 , A61K31/7016 , A61P37/02 , A61P37/08 , A61P17/06 , A61P11/06
CPC分类号： C07H13/04 , A61K31/7008 , A61K31/7024 , C07H11/00 , C07H13/06 , C07H15/14
摘要： Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
摘要翻译： 提供了治疗或改善疾病和其他病症如感染性疾病，自身免疫疾病和过敏症的方法和组合物。 该方法使用基于单糖和二糖的化合物来选择性地刺激动物和植物中的免疫应答。
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5.发明申请PROPHYLACTIC AND THERAPEUTIC TREATMENT OF INFECTIOUS AND OTHER DISEASES WITH MONO- AND DISACCHARIDE-BASED COMPOUNDS 审中-公开感染和治疗单核细胞和基于二磷酸酯的化合物的感染和其他疾病的预防和治疗公开(公告)号：US20080119415A1
公开(公告)日：2008-05-22
申请号：US11957372
申请日：2007-12-14
申请人： David H. Persing , Richard Thomas Crane , Gary T. Elliott , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Ron Wang
发明人： David H. Persing , Richard Thomas Crane , Gary T. Elliott , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Ron Wang
IPC分类号： A61K31/7008
CPC分类号： A61K31/7024 , A61K31/7008 , A61K31/739 , C07H11/00 , C07H13/04 , C07H13/06 , C07H15/14
摘要： Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
摘要翻译： 提供了治疗或改善疾病和其他病症如感染性疾病，自身免疫疾病和过敏症的方法和组合物。 该方法使用基于单糖和二糖的化合物来选择性地刺激动物和植物中的免疫应答。
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6.发明授权公开(公告)号：US06800613B2
公开(公告)日：2004-10-05
申请号：US09861466
申请日：2001-05-18
申请人： David H. Persing , Richard Thomas Crane , Gary T. Elliott , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Rong Wang
发明人： David H. Persing , Richard Thomas Crane , Gary T. Elliott , J. Terry Ulrich , Michael J. Lacy , David A. Johnson , Jory R. Baldridge , Rong Wang
IPC分类号： A61K317016
CPC分类号： C07H13/04 , A61K31/7024 , C07H11/00 , C07H13/06 , C07H15/14
摘要： Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
摘要翻译： 提供了治疗或改善疾病和其他病症如感染性疾病，自身免疫疾病和过敏症的方法和组合物。 该方法使用基于单糖和二糖的化合物来选择性地刺激动物和植物中的免疫应答。
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