公开(公告)号：US20120095519A1

公开(公告)日：2012-04-19

申请号：US13237531

申请日：2011-09-20

申请人： Jordi Parramon ,  Jess W. Shi ,  Emanuel Feldman

发明人： Jordi Parramon ,  Jess W. Shi ,  Emanuel Feldman

IPC分类号： A61N1/372

CPC分类号： A61N1/37241 ,  A61N1/025 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/3605 ,  A61N1/36125 ,  A61N1/36153

摘要： Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation.

摘要翻译： 一种具有多个电极驱动器集成电路（IC）的可植入神经刺激器系统的电极电压监视电路。 可以选择来自任一个或两个IC的电极以提供刺激，并且IC中的一个用作主器件，而另一个用作从器件。 从IC上的电极电压被路由到主IC，因此主IC可以监控从站上的两个电极电压以及主站上的电极电压。 为了各种目的可以监测这样的电压，并且特别地使用这种电压来确定电极之间的电阻并设置用于刺激的顺应性电压。

公开(公告)号：US20080319497A1

公开(公告)日：2008-12-25

申请号：US11767636

申请日：2007-06-25

申请人： Paul J. Griffith ,  Jordi Parramon ,  Goran N. Marnfeldt ,  Daniel Aghassian ,  Kiran Nimmagadda ,  Emanuel Feldman ,  Jess W. Shi

发明人： Paul J. Griffith ,  Jordi Parramon ,  Goran N. Marnfeldt ,  Daniel Aghassian ,  Kiran Nimmagadda ,  Emanuel Feldman ,  Jess W. Shi

IPC分类号： A61N1/08

CPC分类号： A61N1/36125 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36071

摘要： An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC.

摘要翻译： 公开了一种用于植入式医疗装置（例如植入式脉冲发生器（IPG））的改进的架构。 在一个实施例中，用于IPG的各种功能块被并入到信号集成电路（IC）中。 每个功能块通过由通信协议管理的集中式总线彼此通信，并且如果需要，与其他片外设备通信。 为了与总线进行通信并遵守协议，每个电路块包括与该协议相关的总线接口电路。 由于每个块符合协议，任何给定的块都可以轻松修改或升级，而不影响其他块的设计，便于IPG电路的调试和升级。 此外，由于集中式总线可以从集成电路中取出，所以额外的电路可以轻松地从芯片上添加到IPG中，以便对IPG进行主要的重新设计。

公开(公告)号：US08768453B2

公开(公告)日：2014-07-01

申请号：US13237531

申请日：2011-09-20

申请人： Jordi Parramon ,  Jess W. Shi ,  Emanuel Feldman

发明人： Jordi Parramon ,  Jess W. Shi ,  Emanuel Feldman

IPC分类号： A61N1/08

CPC分类号： A61N1/37241 ,  A61N1/025 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/3605 ,  A61N1/36125 ,  A61N1/36153

摘要： Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation.

摘要翻译： 一种具有多个电极驱动器集成电路（IC）的可植入神经刺激器系统的电极电压监视电路。 可以选择来自任一个或两个IC的电极以提供刺激，并且IC中的一个用作主器件，而另一个用作从器件。 从IC上的电极电压被路由到主IC，因此主IC可以监控从站上的两个电极电压以及主站上的电极电压。 为了各种目的可以监测这样的电压，并且特别地使用这种电压来确定电极之间的电阻并设置用于刺激的顺应性电压。

公开(公告)号：US20110015705A1

公开(公告)日：2011-01-20

申请号：US12883797

申请日：2010-09-16

申请人： Paul J. Griffith ,  Jordi Parramon ,  Goran N. Marnfeldt ,  Daniel Aghassisn ,  Kiran Nimmagadda ,  Emanuel Feldman ,  Jess W. Shi

发明人： Paul J. Griffith ,  Jordi Parramon ,  Goran N. Marnfeldt ,  Daniel Aghassisn ,  Kiran Nimmagadda ,  Emanuel Feldman ,  Jess W. Shi

IPC分类号： A61N1/08

CPC分类号： A61N1/36125 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36071

摘要： An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC.

摘要翻译： 公开了一种用于植入式医疗装置（例如植入式脉冲发生器（IPG））的改进的架构。 在一个实施例中，用于IPG的各种功能块被并入到信号集成电路（IC）中。 每个功能块通过由通信协议管理的集中式总线彼此通信，并且如果需要，与其他片外设备通信。 为了与总线进行通信并遵守协议，每个电路块包括与该协议相关的总线接口电路。 由于每个块符合协议，任何给定的块都可以轻松修改或升级，而不影响其他块的设计，便于IPG电路的调试和升级。 此外，由于集中式总线可以从集成电路中取出，所以额外的电路可以轻松地从芯片上添加到IPG中，以便对IPG进行主要的重新设计。

公开(公告)号：US20120095529A1

公开(公告)日：2012-04-19

申请号：US13253552

申请日：2011-10-05

申请人： Jordi Parramon ,  Emanuel Feldman ,  Paul J. Griffith ,  Jess W. Shi

发明人： Jordi Parramon ,  Emanuel Feldman ,  Paul J. Griffith ,  Jess W. Shi

IPC分类号： A61N1/372 ,  A61N1/378

CPC分类号： A61N1/372 ,  A61N1/025 ,  A61N1/36125

摘要： Architectures for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. A parallel bus operating in accordance with a communication protocol couples the ICs, and certain functional blocks not needed in the slave are disabled. Stimulation parameters are loaded via the bus into each IC, and a stimulation enable command is issued on the bus to ensure simultaneous stimulation from the electrodes on both ICs. Clocking strategies are also disclosed to allow clocking of the master and slave ICs to be independently controlled, and to ensure that relevant internal and bus clocks used in the system are synchronized.

摘要翻译： 具有提供的多个电极驱动器集成电路（IC）的可植入神经刺激器系统的结构。 可以选择来自任一个或两个IC的电极以提供刺激，并且IC中的一个用作主器件，而另一个用作从器件。 根据通信协议操作的并行总线耦合IC，并且禁用从机中不需要的某些功能块。 刺激参数通过总线加载到每个IC中，并且在总线上发出刺激使能命令，以确保同时从两个IC上的电极刺激。 还公开了时钟策略，以允许主控和从属IC的时钟被独立控制，并确保系统中使用的相关内部和总线时钟同步。

公开(公告)号：US09795793B2

公开(公告)日：2017-10-24

申请号：US13253552

申请日：2011-10-05

申请人： Jordi Parramon ,  Emanuel Feldman ,  Paul J. Griffith ,  Jess W. Shi

发明人： Jordi Parramon ,  Emanuel Feldman ,  Paul J. Griffith ,  Jess W. Shi

IPC分类号： A61N1/372 ,  A61N1/02

CPC分类号： A61N1/372 ,  A61N1/025 ,  A61N1/36125

摘要： Architectures for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. A parallel bus operating in accordance with a communication protocol couples the ICs, and certain functional blocks not needed in the slave are disabled. Stimulation parameters are loaded via the bus into each IC, and a stimulation enable command is issued on the bus to ensure simultaneous stimulation from the electrodes on both ICs. Clocking strategies are also disclosed to allow clocking of the master and slave ICs to be independently controlled, and to ensure that relevant internal and bus clocks used in the system are synchronized.

公开(公告)号：US09061140B2

公开(公告)日：2015-06-23

申请号：US13237172

申请日：2011-09-20

申请人： Jess W. Shi ,  Emanuel Feldman ,  Jordi Parramon

发明人： Jess W. Shi ,  Emanuel Feldman ,  Jordi Parramon

IPC分类号： G01R27/08 ,  A61N1/08 ,  A61N1/02 ,  A61N1/36 ,  A61B5/04 ,  A61N1/39

CPC分类号： A61N1/36125 ,  A61B5/04001 ,  A61N1/025 ,  A61N1/08 ,  A61N1/378 ,  A61N1/3937

摘要： Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing.

摘要翻译： 公开了用于在可植入神经刺激器中监测电极和其它电压的采样和保持电路。 在一个实施例中，采样和保持电路包含多个选择的合适电压，并在两个不同的测量阶段期间将其传送到两个存储电容器。 电容器串联连接以增加存储在电容器上的两个电压，然后将存在于串行连接顶部和底部的电压输入到差分放大器以计算其差值。 采样和保持电路在计算两个电极之间的电阻时特别有用，当使用双相脉冲测量电阻时，采样和保持电路特别有用。 采样和保持电路是灵活的，并且可以用于在双相或单相脉冲期间测量感兴趣的其他电压。

公开(公告)号：US08649858B2

公开(公告)日：2014-02-11

申请号：US11767636

申请日：2007-06-25

申请人： Paul J. Griffith ,  Jordi Parramon ,  Goran N. Marnfeldt ,  Daniel Aghassian ,  Kiran Nimmagadda ,  Emanuel Feldman ,  Jess W. Shi

发明人： Paul J. Griffith ,  Jordi Parramon ,  Goran N. Marnfeldt ,  Daniel Aghassian ,  Kiran Nimmagadda ,  Emanuel Feldman ,  Jess W. Shi

IPC分类号： A61N1/36 ,  A61N1/08

CPC分类号： A61N1/36125 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36071

摘要： An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC.

摘要翻译： 公开了一种用于植入式医疗装置（例如植入式脉冲发生器（IPG））的改进的架构。 在一个实施例中，用于IPG的各种功能块被并入到信号集成电路（IC）中。 每个功能块通过由通信协议管理的集中式总线彼此通信，并且如果需要，与其他片外设备通信。 为了与总线进行通信并遵守协议，每个电路块包括与该协议相关的总线接口电路。 由于每个块符合协议，任何给定的块都可以轻松修改或升级，而不影响其他块的设计，便于IPG电路的调试和升级。 此外，由于集中式总线可以从集成电路中取出，所以额外的电路可以轻松地从芯片上添加到IPG中，以便对IPG进行主要的重新设计。

公开(公告)号：US20120092031A1

公开(公告)日：2012-04-19

申请号：US13237172

申请日：2011-09-20

申请人： Jess W. Shi ,  Emanuel Feldman ,  Jordi Parramon

发明人： Jess W. Shi ,  Emanuel Feldman ,  Jordi Parramon

IPC分类号： G01R27/08 ,  A61N1/372

CPC分类号： A61N1/36125 ,  A61B5/04001 ,  A61N1/025 ,  A61N1/08 ,  A61N1/378 ,  A61N1/3937

摘要： Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing.

摘要翻译： 公开了用于在可植入神经刺激器中监测电极和其它电压的采样和保持电路。 在一个实施例中，采样和保持电路包含多个选择的合适电压，并在两个不同的测量阶段期间将其传送到两个存储电容器。 电容器串联连接以增加存储在电容器上的两个电压，然后将存在于串行连接顶部和底部的电压输入到差分放大器以计算其差值。 采样和保持电路在计算两个电极之间的电阻时特别有用，当使用双相脉冲测量电阻时，采样和保持电路特别有用。 采样和保持电路是灵活的，并且可以用于在双相或单相脉冲期间测量感兴趣的其他电压。

公开(公告)号：US08131377B2

公开(公告)日：2012-03-06

申请号：US11776170

申请日：2007-07-11

申请人： Jess W. Shi ,  Jordi Parramon

发明人： Jess W. Shi ,  Jordi Parramon

IPC分类号： A61N1/08

CPC分类号： A61N1/37252 ,  A61N1/3605 ,  A61N1/37205 ,  Y10S128/903

摘要： An improved arbitration scheme for allowing concurrent stimulation and telemetry listening in a microstimulator is disclosed. A listening window for telemetry is permitted to proceed, and access to the microstimulator's coil granted, during at least a portion of the inter-pulse period that follows the issuance of a stimulation pulse. This is permissible because access to the coil is not needed during the entirety of the inter-pulse period. For example, the listening window can issue during that portion of the inter-pulse period when the decoupling capacitor is discharged, but cannot issue during that portion of the inter-pulse period when the compliance voltage is being generated for the next stimulation pulse. However, because compliance voltage generation occupies only a small portion of the inter-pulse period, the technique is not substantially limited. By allowing the listening window to issue during the majority of the inter-pulse period, the listening window produces smaller gaps between the pulses, and stimulation therapy is thus brought closer to its ideal.

摘要翻译： 公开了一种用于允许微型激励器中的并发刺激和遥测监听的改进的仲裁方案。 在发出刺激脉冲之后的脉冲间期间的至少一部分期间，允许遥测监听窗口继续进行微型刺激器线圈的访问。 这是允许的，因为在整个脉冲间期间不需要对线圈的访问。 例如，当解耦电容器放电时，在脉冲周期的该部分期间可以发出监听窗口，但是当为下一个刺激脉冲产生顺从性电压时，不能在脉冲间期间的那部分期间发出监听窗口。 然而，由于顺应性电压产生仅占脉冲周期的一小部分，所以该技术基本上不受限制。 通过允许在大多数脉冲间期间发出听音窗口，收听窗口在脉冲之间产生较小的间隙，因此刺激疗法更接近其理想。