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公开(公告)号：US20080161288A1
公开(公告)日：2008-07-03
申请号：US11871345
申请日：2007-11-21
IPC分类号： A61K31/55 , C07D513/06
CPC分类号： C07D487/06
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.
摘要翻译： 式（I）化合物及其药学上可接受的盐是β-2肾上腺素受体的激动剂。 它们可用作家畜饲料添加剂。
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公开(公告)号：US20080267942A1
公开(公告)日：2008-10-30
申请号：US12101317
申请日：2008-04-11
IPC分类号： A61K38/43 , C07D487/06 , A61K31/55
CPC分类号： C07D487/06
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.
摘要翻译： 式（I）化合物及其药学上可接受的盐是β-2肾上腺素受体的激动剂。 它们可用作家畜饲料添加剂。
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公开(公告)号：US20090186924A1
公开(公告)日：2009-07-23
申请号：US12407365
申请日：2009-03-19
申请人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
发明人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
IPC分类号： A61K31/415 , A61K31/4439 , A61K31/427 , C07D401/12 , C07D417/06 , C07D403/12 , C07D231/38 , C07D231/14 , A61P33/00
CPC分类号： C07D231/38 , A01N53/00 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/40 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D487/04
摘要： This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
摘要翻译： 本发明涉及其中环丙基环在角位置被取代的1-芳基-4-环丙基吡唑的范围及其药学上可接受的盐和溶剂化物，包括这些化合物的组合物，其合成方法及其作为杀寄生虫剂的用途。
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公开(公告)号：US20080146643A1
公开(公告)日：2008-06-19
申请号：US11955860
申请日：2007-12-13
申请人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
发明人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
IPC分类号： A61K31/415 , C07D231/10 , A61P33/00
CPC分类号： A61K31/415 , A61K45/06 , C07D231/38 , C07D231/40 , A61K2300/00
摘要： Compounds of formula (I) are used in combination with a second antiparasitic agent for the treatment of parasitic infestations in a host animal.
摘要翻译： 式（I）化合物与第二抗寄生虫剂联合使用，用于治疗宿主动物的寄生虫感染。
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公开(公告)号：US07645786B2
公开(公告)日：2010-01-12
申请号：US11610879
申请日：2006-12-14
申请人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
发明人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D401/12 , A01N53/00 , C07D231/14 , C07D231/16 , C07D231/38 , C07D401/04 , C07D403/12 , C07D405/12 , C07D417/12
摘要： This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
摘要翻译： 本发明涉及其中环丙基环在角位置被取代的1-芳基-4-环丙基吡唑的范围及其药学上可接受的盐和溶剂化物，包括这些化合物的组合物，其合成方法及其作为杀寄生虫剂的用途。
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公开(公告)号：US20080176865A1
公开(公告)日：2008-07-24
申请号：US11955875
申请日：2007-12-13
申请人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
发明人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
IPC分类号： C07D231/38 , A61K31/415 , C07D401/12 , A61K31/4439 , A61K31/427 , C07D403/12 , C07D417/12 , A61K31/497 , A61P33/00
CPC分类号： C07D231/14 , A01N53/00 , C07D231/16 , C07D231/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12
摘要： This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
摘要翻译： 本发明涉及其中环丙基环在角位置被取代的1-芳基-4-环丙基吡唑的范围及其药学上可接受的盐和溶剂化物，包括这些化合物的组合物，其合成方法及其作为杀寄生虫剂的用途。
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公开(公告)号：US07968584B2
公开(公告)日：2011-06-28
申请号：US12407365
申请日：2009-03-19
申请人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
发明人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D231/38 , A01N53/00 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/40 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D487/04
摘要： This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
摘要翻译： 本发明涉及其中环丙基环在角位置被取代的1-芳基-4-环丙基吡唑的范围及其药学上可接受的盐和溶剂化物，包括这些化合物的组合物，其合成方法及其作为杀寄生虫剂的用途。
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公开(公告)号：US07538134B2
公开(公告)日：2009-05-26
申请号：US11453053
申请日：2006-06-14
申请人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
发明人： Denis Billen , Jessica Boyle , Douglas James Critcher , David Morris Gethin , Kim Thomas Hall , Graham Michael Kyne
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D231/38 , A01N53/00 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/40 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D487/04
摘要： This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
摘要翻译： 本发明涉及其中环丙基环在角位置被取代的1-芳基-4-环丙基吡唑的范围及其药学上可接受的盐和溶剂化物，包括这些化合物的组合物，其合成方法及其作为杀寄生虫剂的用途。
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公开(公告)号：US20090137524A1
公开(公告)日：2009-05-28
申请号：US12364879
申请日：2009-02-03
申请人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
发明人： Denis Billen , Nathan Anthony Logan Chubb , David Morris Gethin , Kim Thomas Hall , Lee Richard Roberts , Nigel Derek Arthur Walshe
IPC分类号： A01N43/16 , C07D403/04 , A01N43/40 , A01P1/00 , A01N43/56 , C07D231/14
CPC分类号： C07D401/04 , A61K31/415 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
摘要翻译： 本发明涉及包含式I化合物的组合产品，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 9如本文所述，以及本文所述的一种或多种其它生物活性化合物， - 寄生虫剂。
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公开(公告)号：US06750231B2
公开(公告)日：2004-06-15
申请号：US10100981
申请日：2002-03-19
申请人： Stephen Paul Gibson , Ivan Tommasini , Kimberley Verrier , Christopher James Dutton , David Morris Gethin , Douglas James Critcher , Richard Edward Armer
发明人： Stephen Paul Gibson , Ivan Tommasini , Kimberley Verrier , Christopher James Dutton , David Morris Gethin , Douglas James Critcher , Richard Edward Armer
IPC分类号： C07D40102
CPC分类号： C07D401/10 , C07D211/22 , C07D211/32 , C07D211/34 , C07D401/14 , C07D405/14 , C07D413/10
摘要： There is provided a compound of formula I, wherein Het1, R1, R2, R3, X and n have meanings given in the description, which are useful in the prophylaxis and in the treatment of diseases mediated by opiate receptors, such as pruritus.
摘要翻译： 提供式I化合物，其中Het 1，R 1，R 2，R 3，X和n具有在描述中给出的含义，其可用于预防和治疗 由阿片受体介导的疾病，如瘙痒症。
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