公开(公告)号：US20130331898A1

公开(公告)日：2013-12-12

申请号：US13493531

申请日：2012-06-11

申请人： Jevon Nyemscek ,  Vipin Kunjachan ,  Allison Adams

发明人： Jevon Nyemscek ,  Vipin Kunjachan ,  Allison Adams

IPC分类号： A61K33/42 ,  A61P19/00 ,  A61B17/88

CPC分类号： A61L27/54 ,  A61L24/0005 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/0089 ,  A61L27/3804 ,  A61L27/446 ,  A61L27/50 ,  A61L27/56 ,  A61L2300/412 ,  A61L2430/02 ,  C08L89/06

摘要： Provided are synthetic bone graft substitutes that include bioactive glass and a carrier. Synthetic bone graft substitutes may include bioactive glass, glycerol and polyethylene glycol. Also provided are bone graft substitutes that include collagen and bioactive glass particles. Example bone graft substitutes may include collagen and bioactive glass particles. Other example embodiments may include Type I Bovine Collagen, an angiogenic agent, such as hyaluronic acid, and bioactive glass. Further provided are methods that include administering the present bone graft substitutes to a mammal, e.g., by surgical insertion of the bone graft substitute into the mammal, either alone or in conjunction with one or more implant devices. Further provided are kits that include the present bone grafts.

摘要翻译： 提供包括生物活性玻璃和载体的合成骨移植替代物。 合成骨移植物替代物可以包括生物活性玻璃，甘油和聚乙二醇。 还提供了包括胶原和生物活性玻璃颗粒的骨移植替代物。 骨移植替代物可以包括胶原和生物活性玻璃颗粒。 其它示例性实施方案可以包括I型牛胶原，血管生成剂，例如透明质酸和生物活性玻璃。 还提供了方法，其包括将本发明的骨移植物替代物施用于哺乳动物，例如通过将骨移植物替代物手术插入到哺乳动物中，单独或与一个或多个植入装置结合。 还提供了包括目前骨移植物的试剂盒。

公开(公告)号：US10207027B2

公开(公告)日：2019-02-19

申请号：US13493531

申请日：2012-06-11

申请人： Jevon Nyemscek ,  Vipin Kunjachan ,  Allison Adams

发明人： Jevon Nyemscek ,  Vipin Kunjachan ,  Allison Adams

IPC分类号： A61K35/32 ,  A61K38/18 ,  A61L27/44 ,  A61L27/54 ,  A61L27/38 ,  A61L27/50 ,  A61L27/56 ,  A61L24/00

摘要： Provided are synthetic bone graft substitutes that include bioactive glass and a carrier. Synthetic bone graft substitutes may include bioactive glass, glycerol and polyethylene glycol. Also provided are bone graft substitutes that include collagen and bioactive glass particles. Example bone graft substitutes may include collagen and bioactive glass particles. Other example embodiments may include Type I Bovine Collagen, an angiogenic agent, such as hyaluronic acid, and bioactive glass. Further provided are methods that include administering the present bone graft substitutes to a mammal, e.g., by surgical insertion of the bone graft substitute into the mammal, either alone or in conjunction with one or more implant devices. Further provided are kits that include the present bone grafts.