公开(公告)号：US20210270833A1

公开(公告)日：2021-09-02

申请号：US16755805

申请日：2018-10-15

Applicant: Ji Hoon LEE

Inventor： Ji Hoon LEE ,  Carol T. LEE

IPC: G01N33/569 ,  G01N33/553 ,  G01N33/58

Abstract: A biosensor for detecting an influenza A virus in a sample is disclosed, which includes: an influenza A virus antibody immobilized on a surface of Au—Fe3O4 composite; where the antibody binds with the influenza A virus in the sample, which converts 4-methylumbelliferyl-N-acetyl-α-D-neuraminic acid (MUNANA) to 4-methylumbelliferone (4-MU), where the 4-MU emits green light at pH of 5.5-6.5; and wherein the 4-MU emits blue light at pH of 9.3-11.3. In the biosensor, 1,1′-oxalyldiimidazole chemiluminescence (ODI-CL) reagent may be utilized to emit the blue and green lights.