公开(公告)号：US20080286750A1

公开(公告)日：2008-11-20

申请号：US11841985

申请日：2007-08-20

申请人： Jia XU ,  Antonio Guia ,  Xiaobo Wang ,  Lei Wu ,  Junquan Xu ,  Mingxian Huang ,  David Rothwarf

发明人： Jia XU ,  Antonio Guia ,  Xiaobo Wang ,  Lei Wu ,  Junquan Xu ,  Mingxian Huang ,  David Rothwarf

IPC分类号： C12Q1/00

CPC分类号： G01N33/48728

摘要： The present invention recognizes that the determination of ion transport function or properties using direct detection methods, such as whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and other fluidic components and methods of use that allow for the direct analysis of ion transport function or properties using microfabricated structures that can allow for automated detection of ion transport function or properties. These biochips and fluidic components and methods of use thereof are particularly appropriate for automating the detection of ion transport function or properties, particularly for screening purposes.

摘要翻译： 本发明认识到，使用诸如全细胞记录或单通道记录之类的直接检测方法的离子转运功能或性质的确定优于使用间接检测方法的方法，例如基于FRET的检测系统。 本发明提供生物芯片和其他流体组分和使用方法，其允许使用可允许自动检测离子迁移功能或性质的微结构的直接分析离子转运功能或性质。 这些生物芯片和流体组分及其使用方法特别适用于自动化离子迁移功能或性质的检测，特别是用于筛选目的。