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    APPARATUS INCLUDING ION TRANSPORT DETECTING STRUCTURES AND METHODS OF USE
    1.
    发明申请
    APPARATUS INCLUDING ION TRANSPORT DETECTING STRUCTURES AND METHODS OF USE 审中-公开
    装置包括离子运输检测结构和使用方法

    公开(公告)号：US20080286750A1

    公开(公告)日：2008-11-20

    申请号：US11841985

    申请日：2007-08-20

    申请人： Jia XU ,  Antonio Guia ,  Xiaobo Wang ,  Lei Wu ,  Junquan Xu ,  Mingxian Huang ,  David Rothwarf

    发明人： Jia XU ,  Antonio Guia ,  Xiaobo Wang ,  Lei Wu ,  Junquan Xu ,  Mingxian Huang ,  David Rothwarf

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/48728

    摘要： The present invention recognizes that the determination of ion transport function or properties using direct detection methods, such as whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and other fluidic components and methods of use that allow for the direct analysis of ion transport function or properties using microfabricated structures that can allow for automated detection of ion transport function or properties. These biochips and fluidic components and methods of use thereof are particularly appropriate for automating the detection of ion transport function or properties, particularly for screening purposes.

    摘要翻译： 本发明认识到，使用诸如全细胞记录或单通道记录之类的直接检测方法的离子转运功能或性质的确定优于使用间接检测方法的方法，例如基于FRET的检测系统。 本发明提供生物芯片和其他流体组分和使用方法，其允许使用可允许自动检测离子迁移功能或性质的微结构的直接分析离子转运功能或性质。 这些生物芯片和流体组分及其使用方法特别适用于自动化离子迁移功能或性质的检测，特别是用于筛选目的。

    Apparatus including ion transport detecting structures and methods of use
    2.
    发明申请
    Apparatus including ion transport detecting structures and methods of use 审中-公开
    包括离子传输检测结构和使用方法的装置

    公开(公告)号：US20050009004A1

    公开(公告)日：2005-01-13

    申请号：US10760886

    申请日：2004-01-20

    申请人： Jia Xu ,  Antonio Guia ,  Xiaobo Wang ,  Lei Wu ,  Junquan Xu ,  Mingxian Huang ,  David Rothwarf

    发明人： Jia Xu ,  Antonio Guia ,  Xiaobo Wang ,  Lei Wu ,  Junquan Xu ,  Mingxian Huang ,  David Rothwarf

    IPC分类号： C12M1/34 ,  C12Q1/00 ,  G01N33/487

    CPC分类号： G01N33/48728

    摘要： The present invention recognizes that the determination of ion transport function or properties using direct detection methods, such as whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and other fluidic components and methods of use that allow for the direct analysis of ion transport function or properties using microfabricated structures that can allow for automated detection of ion transport function or properties. These biochips and fluidic components and methods of use thereof are particularly appropriate for automating the detection of ion transport function or properties, particularly for screening purposes.

    摘要翻译： 本发明认识到，使用诸如全细胞记录或单通道记录之类的直接检测方法的离子转运功能或性质的确定优于使用间接检测方法的方法，例如基于FRET的检测系统。 本发明提供生物芯片和其他流体组分和使用方法，其允许使用可允许自动检测离子迁移功能或性质的微结构的直接分析离子转运功能或性质。 这些生物芯片和流体组分及其使用方法特别适用于自动化离子迁移功能或性质的检测，特别是用于筛选目的。

    High-density ion transport measurement biochip devices and methods
    8.
    发明申请
    High-density ion transport measurement biochip devices and methods 审中-公开
    高密度离子传输测量生物芯片器件及方法

    公开(公告)号：US20050196746A1

    公开(公告)日：2005-09-08

    申请号：US11033015

    申请日：2005-01-10

    申请人： Jia Xu ,  Antonio Guia ,  George Walker ,  Mingxian Huang ,  Lei Wu ,  Sithiphong Khachonesin ,  Julian Yuan

    发明人： Jia Xu ,  Antonio Guia ,  George Walker ,  Mingxian Huang ,  Lei Wu ,  Sithiphong Khachonesin ,  Julian Yuan

    IPC分类号： C12Q1/00 ,  G01N33/487

    CPC分类号： G01N33/48728

    摘要： The present invention provides novel biochips, biochip-based devices, and device configurations that can be used for ion transport measurement. The chips, devices, and designs of the present invention are particularly suited to high-throughput assays such as compound screening assays using patch clamping techniques. The invention includes high-density biochips made by novel methods and methods of making high density biochips, and also provides novel upper chamber configurations and fluidics designs for upper chambers of ion transport measurement devices that can be used in high throughput patch clamp assays. The present invention also includes methods of using ion transport measuring chips and devices of the present invention.

    摘要翻译： 本发明提供了可用于离子传输测量的新型生物芯片，基于生物芯片的器件和器件配置。 本发明的芯片，器件和设计特别适用于高通量测定，例如使用贴片钳技术的复合筛选测定法。 本发明包括通过制备高密度生物芯片的新方法和方法制备的高密度生物芯片，并且还提供了可用于高通量膜片钳测定的离子传输测量装置的上腔室的新型上室构型和流体学设计。 本发明还包括使用本发明的离子传输测量芯片和器件的方法。