公开(公告)号：US08192928B2

公开(公告)日：2012-06-05

申请号：US12504034

申请日：2009-07-16

申请人： Jianfeng Xu ,  Deborah Meyers ,  Sigun Zheng ,  Patrick C. Walsh ,  William B. Isaacs ,  Eugene Bleecker ,  David Herrington

发明人： Jianfeng Xu ,  Deborah Meyers ,  Sigun Zheng ,  Patrick C. Walsh ,  William B. Isaacs ,  Eugene Bleecker ,  David Herrington

IPC分类号： C12Q1/68

CPC分类号： C07K14/705 ,  C12Q1/6886 ,  C12Q2600/172

摘要： The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain diseases, such as cancer asthma and/or cardiovascular diseases.

摘要翻译： 本发明公开了筛选受试者增加某些疾病或病症的可能性或风险的方法。 该方法包括检测MSR1基因中存在或不存在至少一个突变，其中这种突变的存在或不存在表明某些疾病如癌症哮喘和/或心血管疾病的风险增加。

公开(公告)号：US07579147B2

公开(公告)日：2009-08-25

申请号：US10426262

申请日：2003-04-30

申请人： Jianfeng Xu ,  Deborah Meyers ,  Sigun Zheng ,  Patrick C. Walsh ,  William B. Isaacs ,  Eugene Bleecker ,  David Herrington

发明人： Jianfeng Xu ,  Deborah Meyers ,  Sigun Zheng ,  Patrick C. Walsh ,  William B. Isaacs ,  Eugene Bleecker ,  David Herrington

IPC分类号： C12Q1/68

CPC分类号： C07K14/705 ,  C12Q1/6886 ,  C12Q2600/172

摘要： The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain diseases, such as cancer asthma and/or cardiovascular diseases.

摘要翻译： 本发明公开了筛选受试者增加某些疾病或病症的可能性或风险的方法。 该方法包括检测MSR1基因中存在或不存在至少一个突变，其中这种突变的存在或不存在表明某些疾病如癌症哮喘和/或心血管疾病的风险增加。

公开(公告)号：US20100267024A1

公开(公告)日：2010-10-21

申请号：US12504034

申请日：2009-07-16

申请人： Jianfeng Xu ,  Deborah Meyers ,  Sigun Zheng ,  Patrick C. Walsh ,  William B. Isaacs ,  Eugene Bleecker ,  David Herrington

发明人： Jianfeng Xu ,  Deborah Meyers ,  Sigun Zheng ,  Patrick C. Walsh ,  William B. Isaacs ,  Eugene Bleecker ,  David Herrington

IPC分类号： C12Q1/68 ,  C07K14/435 ,  C12N5/10 ,  C07H21/04

CPC分类号： C07K14/705 ,  C12Q1/6886 ,  C12Q2600/172

摘要： The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain diseases, such as cancer asthma and/or cardiovascular diseases.

摘要翻译： 本发明公开了筛选受试者增加某些疾病或病症的可能性或风险的方法。 该方法包括检测MSR1基因中存在或不存在至少一个突变，其中这种突变的存在或不存在表明某些疾病如癌症哮喘和/或心血管疾病的风险增加。

公开(公告)号：US20070082478A1

公开(公告)日：2007-04-12

申请号：US10577365

申请日：2004-10-04

申请人： David Lind ,  Deborah Meyers ,  Marilyn Shope

发明人： David Lind ,  Deborah Meyers ,  Marilyn Shope

IPC分类号： H01L21/4763

CPC分类号： C08F283/12 ,  C08G77/045 ,  C08G77/12 ,  C08G77/16 ,  C08G77/20 ,  C08G77/24 ,  C08G77/70 ,  C08G77/80 ,  C08G2270/00 ,  C08J3/03 ,  C08J2383/04 ,  C08L25/00 ,  C08L27/00 ,  C08L33/00 ,  C08L33/10 ,  C08L83/04 ,  C08F220/10 ,  C08L2666/04

摘要： Emulsion compositions containing a silicone polymer and organic polymer as an alloy and/or hybrid emulsion can be made by (i) first forming an emulsion containing a silicone polymer by emulsion polymerization in which (a) the ring of a cyclic siloxane oligomer is opened, in which (b)an hydroxy endblocked siloxane oligomer is condensed, using an acid or base catalyst in the presence of water, or in which (c) an hydrogen endblocked siloxane oligomer and a vinyl endblocked siloxane oligomer are reacted by hydrosilylation using a catalyst; (ii) adding to the emulsion in (i) the components for preparing an emulsion containing an organic polymer by free radical emulsion polymerization of an ethylenically unsaturated organic monomer, and (iii) heating the emulsion. The resulting coalesced compositions produce polymer blends or alloys whose properties are influenced by the composition and morphology of the hybrid emulsion particles. The compositions may be spray dried whenever it is desired to employ the particles in powder type applications. In an embodiment, the two emulsions are prepared separately of one another and then combined.

摘要翻译： 含有有机硅聚合物和有机聚合物作为合金和/或混合乳液的乳液组合物可以通过以下方法制备：（i）首先通过乳液聚合形成含有硅氧烷聚合物的乳液，其中（a）环状硅氧烷低聚物的环被打开， 其中（b）羟基封端的硅氧烷低聚物在水存在下使用酸或碱催化剂缩合，或其中（c）氢封端的硅氧烷低聚物和乙烯基封端的硅氧烷低聚物通过使用催化剂的氢化硅烷化反应; （ii）在（i）通过烯键式不饱和有机单体的自由基乳液聚合制备含有机聚合物的乳液的组分中加入乳液，和（iii）加热乳液。 所得到的聚结组合物产生聚合物共混物或合金，其性质受混合乳液颗粒的组成和形态的影响。 无论何时需要在粉末应用中使用颗粒，组合物可以喷雾干燥。 在一个实施方案中，两种乳液彼此分开制备，然后组合。

公开(公告)号：US07767747B2

公开(公告)日：2010-08-03

申请号：US10577365

申请日：2004-10-04

申请人： David Lind ,  Deborah Meyers ,  Marilyn Shope

发明人： David Lind ,  Deborah Meyers ,  Marilyn Shope

IPC分类号： C08K3/20 ,  C08G77/06 ,  C08G77/10

CPC分类号： C08F283/12 ,  C08G77/045 ,  C08G77/12 ,  C08G77/16 ,  C08G77/20 ,  C08G77/24 ,  C08G77/70 ,  C08G77/80 ,  C08G2270/00 ,  C08J3/03 ,  C08J2383/04 ,  C08L25/00 ,  C08L27/00 ,  C08L33/00 ,  C08L33/10 ,  C08L83/04 ,  C08F220/10 ,  C08L2666/04

摘要： Emulsion compositions containing a silicone polymer and organic polymer as an alloy and/or hybrid emulsion can be made by (i) first forming an emulsion containing a silicone polymer by emulsion polymerization in which (a) the ring of a cyclic siloxane oligomer is opened, in which (b)an hydroxy endblocked siloxane oligomer is condensed, using an acid or base catalyst in the presence of water, or in which (c) an hydrogen endblocked siloxane oligomer and a vinyl endblocked siloxane oligomer are reacted by hydrosilylation using a catalyst; (ii) adding to the emulsion in (i) the components for preparing an emulsion containing an organic polymer by free radical emulsion polymerization of an ethylenically unsaturated organic monomer, and (iii) heating the emulsion. The resulting coalesced compositions produce polymer blends or alloys whose properties are influenced by the composition and morphology of the hybrid emulsion particles. The compositions may be spray dried whenever it is desired to employ the particles in powder type applications. In an embodiment, the two emulsions are prepared separately of one another and then combined.

摘要翻译： 含有有机硅聚合物和有机聚合物作为合金和/或混合乳液的乳液组合物可以通过以下方法制备：（i）首先通过乳液聚合形成含有硅氧烷聚合物的乳液，其中（a）环状硅氧烷低聚物的环被打开， 其中（b）羟基封端的硅氧烷低聚物在水存在下使用酸或碱催化剂缩合，或其中（c）氢封端的硅氧烷低聚物和乙烯基封端的硅氧烷低聚物通过使用催化剂的氢化硅烷化反应; （ii）在（i）通过烯键式不饱和有机单体的自由基乳液聚合制备含有机聚合物的乳液的组分中加入乳液，和（iii）加热乳液。 所得到的聚结组合物产生聚合物共混物或合金，其性质受混合乳液颗粒的组成和形态的影响。 无论何时需要在粉末应用中使用颗粒，组合物可以喷雾干燥。 在一个实施方案中，两种乳液彼此分开制备，然后组合。