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    Method and system for delivering cardiac resynchronization therapy with variable atrio-ventricular delay
    1.
    发明授权
    Method and system for delivering cardiac resynchronization therapy with variable atrio-ventricular delay 有权
    用心脏再同步治疗可变心房延迟的方法和系统

    公开(公告)号：US08121685B2

    公开(公告)日：2012-02-21

    申请号：US12622602

    申请日：2009-11-20

    申请人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    发明人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.

    摘要翻译： 起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。 在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。 反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

    Method and system for delivering cardiac resynchronization therapy with variable atrio-ventricular delay
    2.
    发明授权
    Method and system for delivering cardiac resynchronization therapy with variable atrio-ventricular delay 有权
    用心脏再同步治疗可变心房延迟的方法和系统

    公开(公告)号：US07630764B2

    公开(公告)日：2009-12-08

    申请号：US11206394

    申请日：2005-08-18

    申请人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    发明人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.

    摘要翻译： 起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。 在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。 反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

    Method and system for delivering cardiac resynchronization therapy with variable atrio-ventricular delay
    3.
    发明授权
    Method and system for delivering cardiac resynchronization therapy with variable atrio-ventricular delay 有权
    用心脏再同步治疗可变心房延迟的方法和系统

    公开(公告)号：US07123960B2

    公开(公告)日：2006-10-17

    申请号：US10744944

    申请日：2003-12-22

    申请人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    发明人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method is presented by which an implantable cardiac rhythm management device may vary the atrio-ventricular delay or AVD interval used for delivering cardiac resynchronization therapy in an atrial tracking or AV sequential pacing mode in accordance with the sensed or paced atrial rate. Optimal values for the AVD parameter associated with a particular atrial rate are computed as linear functions of an intrinsic conduction measurement taken when the particular rate is present.

    摘要翻译： 提出一种方法，通过该方法，可植入的心律管理装置可以根据感测或起搏的心房率改变用于在心房跟踪或AV顺序起搏模式中递送心脏再同步治疗的心房延迟或AVD间隔。 与特定心房率相关的AVD参数的最佳值被计算为当存在特定速率时所进行的本征传导测量的线性函数。

    Method and system for treatment of mechanical cardiac asynchrony
    4.
    发明授权
    Method and system for treatment of mechanical cardiac asynchrony 有权
    用于治疗机械心脏不同步的方法和系统

    公开(公告)号：US08538519B2

    公开(公告)日：2013-09-17

    申请号：US11113827

    申请日：2005-04-25

    申请人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    发明人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36528 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A system and method for identifying patients with asynchronous ventricular contractions due to abnormal electro-mechanical coupling and computing optimal pacing parameters for restoring synchronous contractions is disclosed. Such patients may have normal intra-ventricular and inter-ventricular conduction and cannot be identified from intrinsic conduction data alone such as QRS width. Techniques for computing optimal resynchronization pacing in order to compensate for abnormal electro-mechanical coupling are also described.

    摘要翻译： 公开了一种用于识别异常心电耦合异常心室收缩患者的系统和方法，并且计算用于恢复同步收缩的最佳起搏参数。 这样的患者可能具有正常的心室内和心室间传导，并且不能从内在传导数据单独识别，如QRS宽度。 还描述了用于计算最佳再同步起搏以补偿异常机电耦合的技术。

    METHOD AND SYSTEM FOR DELIVERING CARDIAC RESYNCHRONIZATION THERAPY WITH VARIABLE ATRIO-VENTRICULAR DELAY
    6.
    发明申请
    METHOD AND SYSTEM FOR DELIVERING CARDIAC RESYNCHRONIZATION THERAPY WITH VARIABLE ATRIO-VENTRICULAR DELAY 有权
    用可变ATRIO-VENTRICULAR延迟递送心脏再生治疗的方法和系统

    公开(公告)号：US20120165893A1

    公开(公告)日：2012-06-28

    申请号：US13398458

    申请日：2012-02-16

    申请人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    发明人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.

    摘要翻译： 起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。 在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。 反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

    METHOD AND SYSTEM FOR DELIVERING CARDIAC RESYNCHRONIZATION THERAPY WITH VARIABLE ATRIO-VENTRICULAR DELAY
    7.
    发明申请
    METHOD AND SYSTEM FOR DELIVERING CARDIAC RESYNCHRONIZATION THERAPY WITH VARIABLE ATRIO-VENTRICULAR DELAY 有权
    用可变ATRIO-VENTRICULAR延迟递送心脏再生治疗的方法和系统

    公开(公告)号：US20100069988A1

    公开(公告)日：2010-03-18

    申请号：US12622602

    申请日：2009-11-20

    申请人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    发明人： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

    IPC分类号： A61N1/368

    CPC分类号： A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.

    摘要翻译： 起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。 在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。 反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

    Automatic determination of chronotropic incompetence using atrial pacing at rest
    8.
    发明授权
    Automatic determination of chronotropic incompetence using atrial pacing at rest 有权
    使用心房起搏静息自动确定时间性无能力

    公开(公告)号：US09132275B2

    公开(公告)日：2015-09-15

    申请号：US13290362

    申请日：2011-11-07

    申请人： Yinghong Yu ,  Donald L. Hopper ,  Jiang Ding ,  James O. Gilkerson

    发明人： Yinghong Yu ,  Donald L. Hopper ,  Jiang Ding ,  James O. Gilkerson

    IPC分类号： A61N1/36 ,  A61N1/368

    CPC分类号： A61N1/3682

    摘要： An apparatus comprises an implantable cardiac signal sensing circuit that provides an electrical cardiac signal representative of cardiac activity of a subject, an implantable therapy circuit that delivers electrical pacing stimulation energy to a heart of a subject, and a controller circuit. The controller circuit includes a chronotropic incompetence detection circuit that initiates pacing of an atrium of the subject at a rate higher than a device-indicated rate or a sensed intrinsic rate, monitor the AV interval, initiates an increase in the pacing rate while continuing the monitoring of the AV interval, calculates a change in AV intervals between a highest paced rate used in the monitoring and a lowest paced rate used in the monitoring, and indicates that the AV intervals are evidence of chronotropic incompetence when the calculated change in the AV intervals exceeds a specified threshold AV interval change value.

    摘要翻译： 一种装置包括可植入心脏信号感测电路，其提供代表受试者的心脏活动的电心脏信号，将对该对象的心脏发出电起搏刺激能量的可植入治疗电路以及控制器电路。 控制器电路包括一个变时无能检测电路，其以高于设备指示速率或感测到的固有频率的速率启动对象的心房起搏，监视AV间隔，启动起搏速率的增加，同时继续监视 计算AV监视中使用的最高起搏速率和监视中使用的最低起搏速度之间的AV间隔的变化，并且指示AV间隔是当计算出的AV间隔的变化超过时间间隔无能力的证据 指定的阈值AV间隔变化值。

    OPTIMIZATION OF LV AND RV LEAD PLACEMENT BASED ON ELECTRICAL DELAYS
    10.
    发明申请
    OPTIMIZATION OF LV AND RV LEAD PLACEMENT BASED ON ELECTRICAL DELAYS 有权
    基于电延迟优化LV和RV导线放置

    公开(公告)号：US20130190636A1

    公开(公告)日：2013-07-25

    申请号：US13552996

    申请日：2012-07-19

    申请人： Shibaji Shome ,  Pramodsingh Hirasingh Thakur ,  Yinghong Yu ,  Keith L. Herrmann ,  Aaron R. McCabe ,  Jiang Ding

    发明人： Shibaji Shome ,  Pramodsingh Hirasingh Thakur ,  Yinghong Yu ,  Keith L. Herrmann ,  Aaron R. McCabe ,  Jiang Ding

    IPC分类号： A61B5/0456 ,  A61B5/04

    CPC分类号： A61B5/0456 ,  A61B5/04012 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/3702 ,  A61N1/37247 ,  A61N1/3918

    摘要： A system comprises a cardiac signal sensing and a processing circuit. The cardiac signal sensing circuit senses a first cardiac signal segment that includes a QRS complex and a second cardiac signal segment that includes a fiducial indicative of local ventricular activation. The processor circuit includes a site activation timer circuit configured to determine a time duration between a fiducial of the QRS complex of the first cardiac signal segment and the fiducial of the second cardiac signal segment. The processor circuit is configured to generate, using the determined time duration, an indication of optimality of placement of one or more electrodes for delivering therapy and provide the indication to at least one of a user or process.

    摘要翻译： 一种系统包括心脏信号感测和处理电路。 心脏信号感测电路感测包括QRS复合物的第一心脏信号片段和包括指示局部心室激活的基准的第二心脏信号片段。 处理器电路包括站点激活定时器电路，其被配置为确定第一心脏信号段的QRS复合体的基准点与第二心脏信号段的基准点之间的持续时间。 处理器电路被配置为使用所确定的持续时间来生成用于递送治疗的一个或多个电极的放置的最佳化的指示，并向至少一个用户或过程提供指示。