公开(公告)号：US10907009B1

公开(公告)日：2021-02-02

申请号：US16965183

申请日：2018-02-11

申请人： JIANGNAN UNIVERSITY

发明人： Ren Liu ,  Zhiquan Li ,  Liping Zhang ,  Yangyang Xu

IPC分类号： C08G59/17 ,  C08G59/42 ,  C08G59/14 ,  C09D163/10 ,  C08G59/62 ,  G03F7/031 ,  C09J163/10

摘要： The present invention discloses modified epoxy acrylates and the solder resist containing the epoxy modified acrylates, belonging to the synthetic resin field. In this invention, modified epoxy acrylates are prepared by introducing long fatty hydrocarbon chain as the branched chain into the carboxylated epoxy acrylates. The as-prepared solder resist containing this modified epoxy acrylates maintains the excellent property of photosensitive solder resist such as good adhesion, hardness, solvent resistance and weather resistance which facilities sensitivity and alkaline development during exposure simultaneously. This has led to good water resistance, electrical insulation of the cured products. Furthermore, the cured product also shows good flexibility which improves its application in photosensitive imaging ink materials.

公开(公告)号：US11191728B2

公开(公告)日：2021-12-07

申请号：US16928186

申请日：2020-07-14

申请人： JIANGNAN UNIVERSITY

发明人： Caihua Ni ,  Zhenle Tian ,  Gang Wang ,  Liping Zhang ,  Ren Liu

IPC分类号： A61K31/704 ,  A61K9/19 ,  C08G63/06 ,  C08J3/14 ,  C08J3/075

摘要： A method of preparing degradable and environment responsive composite microgels, belonging to polymer material synthesis and biomaterial technology fields. Firstly, a copolymer of L-malic acid and 6-hydroxyhexanoate is prepared; then, N,N,N′,N′-tetramethyl cystamine is prepared. The copolymer and N,N,N′,N′-tetramethyl cystamine are mixed in an organic solvent to form a mixed solution which is added into excess distilled water to produce composite microgels. The microgels have advantages of mild preparing conditions, fast reaction speed without catalysts, no impurity remained, and controllable degradation rate. The microgels can load anticancer drug doxorubicin hydrochloride, showing environment responsive controlled release due to introduction of carboxyl groups and disulfide bonds.

公开(公告)号：US09969703B2

公开(公告)日：2018-05-15

申请号：US15551594

申请日：2016-01-20

申请人： Jiangnan University

发明人： Ren Liu ,  Xiaopeng Zhang ,  Zhiquan Li ,  Jingcheng Liu ,  Jing Luo ,  Xiaoya Liu

IPC分类号： C07D251/70 ,  C09D167/06 ,  C08F22/22

CPC分类号： C07D251/70 ,  C08F22/22 ,  C08F2220/283 ,  C09D167/06

摘要： The present invention discloses a triazine-containing photocurable resin and a preparation method thereof. The preparation method of the resin comprises the following steps of: (1) Dissolving the hexamethylolmelamine the unsaturated fatty acids and a catalyst in a solvent, keeping a reaction going, separating and extracting the reaction product after the reaction ends, obtaining triazine-containing fatty acid ester; (2) adding 50 wt % hydrogen peroxide, a catalyst and a solvent, namely methylbenzene, into the triazine-containing fatty acid ester prepared in step (1), keeping a reaction going, obtaining triazine-containing fatty acid ester epoxy resin; (3) adding a polymerization inhibitor and a catalyst into acrylic acid, dropping the triazine-containing fatty acid ester epoxy resin prepared in step (2), keeping a reaction going, and obtaining the triazine-containing photocurable resin. The photocurable resin of the present invention contains a rigid triazine and flexible fatty chains at the same time, so the cured object has excellent comprehensive performance and can be used as the photocurable resin in the field of photosensitive macromolecular materials.

公开(公告)号：US10933028B2

公开(公告)日：2021-03-02

申请号：US16494993

申请日：2018-12-03

申请人： JIANGNAN UNIVERSITY

发明人： Liping Zhang ,  Caihua Ni ,  Ren Liu ,  Dawei Wang ,  Gang Shi ,  Xinxin Sang ,  Xiaofeng Xia

IPC分类号： A61K9/51 ,  A61K31/337 ,  A61K31/351

摘要： The invention discloses a preparation method of pH/reduction responsive polyamino acid zwitterionic nanoparticles, which belongs to the technical field of polymer synthesis and biomedical materials. In the invention aliphatic amines are used to initiate ring-opening polymerization of γ-benzyl-L-glutamate-N-carboxylic anhydride, and the obtained poly(γ-benzyl-L-glutamate) reacts with L-lysine to form azwitterionic polymer. The zwitterionic polymer is crosslinked by cysteamine, producing pH/reduction responsive polyamino acid zwitterionic nanoparticles after purification. The nanoparticles are pH responsive and resistant to non-specific protein adsorption. Because cysteamine contains disulfide bonds, the nanoparticles have sensitive reductive responsiveness and can load anticancer drugs for controlled release at the target site of cancer.

公开(公告)号：US10682312B2

公开(公告)日：2020-06-16

申请号：US16159058

申请日：2018-10-12

申请人： JIANGNAN UNIVERSITY

发明人： Liping Zhang ,  Caihua Ni ,  Ren Liu ,  He Liu ,  Xinyi Dong

IPC分类号： A61K9/107 ,  C08G81/00 ,  A61K31/704 ,  C08G83/00 ,  C08G69/10 ,  C08G69/42

摘要： Hybrid amphiphilic star copolymer nano micelles are prepared in the invention. Cage shaped octa(γ-aminopropyl) silsesquioxanes is selected as the inorganic part, and L-glutamic benzyl ester—five membered ring anhydride is ring-opening polymerized by the initiation of amino groups on the surface of cage shaped octa(γ-aminopropyl) silsesquioxanes, producing copolymers with cage shaped octa(γ-aminopropyl) silsesquioxanes as nucleus and poly (L-glutamic-benzyl ester) as arms. The copolymers reacts with monomethoxy poly (ethylene glycol) carboxylic acid by condensation. Finally, the benzyl groups in the side chains of poly (L-glutamic acid-benzyl ester) are converted into hydrazine groups by acylhydrazination to obtain hybrid amphiphilic star copolymer nano micelles. The micelles can load doxorubicin, they are safe to human body and have good application prospects.

公开(公告)号：US11623968B2

公开(公告)日：2023-04-11

申请号：US16954734

申请日：2019-11-26

申请人： JIANGNAN UNIVERSITY

发明人： Liping Zhang ,  Caihua Ni ,  Ren Liu ,  Gang Wang

IPC分类号： C08B37/00 ,  A61K9/107 ,  A61K9/14 ,  A61K31/723 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

摘要： A method for making xanthan gum copolymer nanomicelles comprising: 1) degrading xanthan gum in aqueous solution to obtain degraded xanthan gum; 2) preparing xanthan gum bromide from the degraded xanthan gum; 3) preparing xanthan gum copolymer from the xanthan gum bromide and 4) making the gum copolymer nanomicelles from the xanthan gum copolymer. The xanthan gum copolymer nanomicelles have good morphological regularity, good biocompatibility and stable performance as an anticancer drug carriers.