公开(公告)号：US08447406B2

公开(公告)日：2013-05-21

申请号：US12826172

申请日：2010-06-29

申请人： Jianping Wu ,  Steven L. Jensen ,  Dwight E. Nelson

发明人： Jianping Wu ,  Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61B5/0482 ,  A61N1/08

CPC分类号： A61N1/00

摘要： Bioelectrical signals may be sensed within the brain by two or more electrodes to determine characteristics of a function of the brain. The signals obtained by the electrodes may be plotted over time to determine whether the brain function exhibits a normal or an abnormal pattern. If the brain function exhibits an abnormal pattern, an implantable medical device may dynamically determine based on the abnormal pattern and a previously-obtained plot associated with normal brain function, an appropriate electrical stimulation therapy. Application of the appropriate electrical stimulation therapy causes the brain function to shift from the abnormal pattern to the normal pattern.

摘要翻译： 可以通过两个或更多个电极在脑内感测生物电信号，以确定大脑功能的特征。 可以随时间绘制由电极获得的信号，以确定脑功能是否呈现正常或异常图案。 如果大脑功能呈现异常模式，则植入式医疗设备可以基于异常模式和与正常脑功能相关联的先前获得的情景（适当的电刺激治疗）来动态地确定。 适当的电刺激治疗的应用使脑功能从异常模式转移到正常模式。

公开(公告)号：US09878161B2

公开(公告)日：2018-01-30

申请号：US13446801

申请日：2012-04-13

申请人： Jianping Wu ,  Steven L. Jensen ,  Dwight E. Nelson

发明人： Jianping Wu ,  Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/00 ,  A61N1/36

CPC分类号： A61N1/36171 ,  A61N1/36067 ,  A61N1/36139

摘要： The disclosure relates to the delivery of electrical stimulation therapy to the brain of a patient, e.g., to treat or otherwise manage a patient disorder. In one example, the disclosure relates to a method comprising generating electrical stimulation via a medical device; delivering the electrical stimulation at a first frequency to a brain of a patient when the bioelectrical brain signals of the patient oscillate at a second frequency, where the second frequency corresponds to pathological brain signals of the patient, where the electrical stimulation is selected to entrain the bioeiectrical brain signals of the patient; and adjusting the delivered electrical stimulation from the first frequency to a third frequency, where adjusting the delivered electrical stimulation changes the bioelectrical brain signal oscillations to a fourth frequency different from the second frequency. The fourth frequency may correspond to an oscillation frequency of non-pathological brain signals of the patient.

公开(公告)号：US20120277820A1

公开(公告)日：2012-11-01

申请号：US13446801

申请日：2012-04-13

申请人： Jianping Wu ,  Steven L. Jensen ,  Dwight E. Nelson

发明人： Jianping Wu ,  Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/36

CPC分类号： A61N1/36171 ,  A61N1/36067 ,  A61N1/36139

摘要： The disclosure relates to the delivery of electrical stimulation therapy to the brain of a patient, e.g., to treat or otherwise manage a patient disorder. In one example, the disclosure relates to a method comprising generating electrical stimulation via a medical device; delivering the electrical stimulation at a first frequency to a brain of a patient when the bioelectrical brain signals of the patient oscillate at a second frequency, where the second frequency corresponds to pathological brain signals of the patient, where the electrical stimulation is selected to entrain the bioeiectrical brain signals of the patient; and adjusting the delivered electrical stimulation from the first frequency to a third frequency, where adjusting the delivered electrical stimulation changes the bioelectrical brain signal oscillations to a fourth frequency different from the second frequency. The fourth frequency may correspond to an oscillation frequency of non-pathological brain signals of the patient.

摘要翻译： 本公开涉及将电刺激治疗递送到患者的大脑，例如治疗或以其他方式治疗患者病症。 在一个示例中，本公开涉及一种包括经由医疗装置产生电刺激的方法; 当患者的生物电脑信号以第二频率振荡时，将第一频率的电刺激递送到患者的大脑，其中第二频率对应于患者的病理性脑信号，其中选择电刺激以夹带 患者生物大脑信号; 以及将所递送的电刺激从所述第一频率调整到第三频率，其中调节所输送的电刺激将所述生物电脑信号振荡改变到与所述第二频率不同的第四频率。 第四频率可以对应于患者的非病理性脑信号的振荡频率。

公开(公告)号：US20110319962A1

公开(公告)日：2011-12-29

申请号：US12826172

申请日：2010-06-29

申请人： Wu Jianping ,  Steven L. Jensen ,  Dwight E. Nelson

发明人： Wu Jianping ,  Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/05

CPC分类号： A61N1/00

摘要： Bioelectrical signals may be sensed within the brain by two or more electrodes to determine characteristics of a function of the brain. The signals obtained by the electrodes may be plotted over time to determine whether the brain function exhibits a normal or an abnormal pattern. If the brain function exhibits an abnormal pattern, an implantable medical device may dynamically determine based on the abnormal pattern and a previously-obtained plot associated with normal brain function, an appropriate electrical stimulation therapy. Application of the appropriate electrical stimulation therapy causes the brain function to shift from the abnormal pattern to the normal pattern.

摘要翻译： 可以通过两个或更多个电极在脑内感测生物电信号，以确定大脑功能的特征。 可以随时间绘制由电极获得的信号，以确定脑功能是否呈现正常或异常图案。 如果大脑功能呈现异常模式，则植入式医疗设备可以基于异常模式和与正常脑功能相关联的先前获得的情景（适当的电刺激治疗）来动态地确定。 适当的电刺激治疗的应用使脑功能从异常模式转移到正常模式。

公开(公告)号：US20110230936A1

公开(公告)日：2011-09-22

申请号：US12727889

申请日：2010-03-19

申请人： Steven L. Jensen ,  Dwight E. Nelson

发明人： Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/05 ,  A61N1/00

CPC分类号： A61N1/36146 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139

摘要： This disclosure describes techniques for delivering electrical stimulation at one or more phases relative to an ongoing oscillating signal in a patient, and then mapping the response to the oscillating signal. The techniques may reduce or eliminate the oscillating signal. In one example, the disclosure is directed to a method that includes delivering a set of first electrical stimulation at a plurality of phases relative to an oscillating signal, measuring a response in the oscillating signal to the set of first electrical stimulation after delivering electrical stimulation at each respective phase of the plurality of phases, determining a phase at which to deliver second electrical stimulation based on the measured responses, and delivering the second electrical stimulation to the patient at the determined phase to produce a therapeutic effect.

摘要翻译： 本公开描述了相对于患者中正在进行的振荡信号在一个或多个相位递送电刺激的技术，然后将响应映射到振荡信号。 这些技术可以减少或消除振荡信号。 在一个示例中，本公开涉及一种方法，其包括相对于振荡信号在多个相位递送一组第一电刺激，在将电刺激传递到第一电刺激之后测量振荡信号中的响应到第一电刺激 确定基于所测量的响应来传递第二电刺激的相位，以及在确定的阶段将第二电刺激递送给患者以产生治疗效果。

公开(公告)号：US08583254B2

公开(公告)日：2013-11-12

申请号：US13338751

申请日：2011-12-28

申请人： Steven L. Jensen ,  Dwight E. Nelson

发明人： Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/05

CPC分类号： A61N1/36146 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139

摘要： This disclosure describes techniques for delivering electrical stimulation at one or more phases relative to an ongoing oscillating signal in a patient, and then mapping the response to the oscillating signal. The techniques may reduce or eliminate the oscillating signal. In one example, the disclosure is directed to a method that includes delivering a set of first electrical stimulation at a plurality of phases relative to an oscillating signal, measuring a response in the oscillating signal to the set of first electrical stimulation after delivering electrical stimulation at each respective phase of the plurality of phases, determining a phase at which to deliver second electrical stimulation based on the measured responses, and delivering the second electrical stimulation to the patient at the determined phase to produce a therapeutic effect.

摘要翻译： 本公开描述了相对于患者中正在进行的振荡信号在一个或多个相位递送电刺激的技术，然后将响应映射到振荡信号。 这些技术可以减少或消除振荡信号。 在一个示例中，本公开涉及一种方法，其包括相对于振荡信号在多个相位递送一组第一电刺激，在将电刺激传递到第一电刺激之后测量振荡信号中的响应到第一电刺激 确定基于所测量的响应来传递第二电刺激的相位，以及在确定的阶段将第二电刺激递送给患者以产生治疗效果。

公开(公告)号：US08868173B2

公开(公告)日：2014-10-21

申请号：US13446459

申请日：2012-04-13

申请人： Dwight E. Nelson ,  Rahul Agarwal ,  Steven L. Jensen ,  Rahul Gupta

发明人： Dwight E. Nelson ,  Rahul Agarwal ,  Steven L. Jensen ,  Rahul Gupta

IPC分类号： A61B5/04 ,  A61B5/0476 ,  A61N1/36 ,  A61N1/372 ,  A61B5/0496 ,  A61M5/142 ,  A61N1/05

CPC分类号： A61N1/36139 ,  A61B5/0476 ,  A61B5/0496 ,  A61M5/14276 ,  A61M2005/14208 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36132 ,  A61N1/36153 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36185 ,  A61N1/37247

摘要： Various embodiments concern sensing a LFP signal from one or more electrodes, measuring the amplitude of the signals over a period of time, and calculating a plurality of variance values from the amplitude, wherein each of the variance values correspond to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values. Such embodiments may further include assessing the relative level of neural activation of an area of the brain based on the variance values, wherein the area of the brain is assessed to have a relatively higher level of neural activation when the variance is relatively higher and the area of the brain is assessed to have a relatively lower level of neural activation when the variance is relatively lower.

摘要翻译： 各种实施例涉及感测来自一个或多个电极的LFP信号，在一段时间内测量信号的幅度，以及从幅度计算多个方差值，其中每个方差值对应于幅度的方差 相对于其他方差值的时间段的不同时间间隔。 这样的实施方案可以进一步包括基于方差值评估脑区域的神经激活的相对水平，其中当方差相对较高时评估脑的面积具有相对较高水平的神经激活， 当方差相对较低时，脑的评估具有相对较低水平的神经激活。

公开(公告)号：US20120271189A1

公开(公告)日：2012-10-25

申请号：US13446459

申请日：2012-04-13

申请人： Dwight E. Nelson ,  Rahul Agarwal ,  Steven L. Jensen ,  Rahul Gupta

发明人： Dwight E. Nelson ,  Rahul Agarwal ,  Steven L. Jensen ,  Rahul Gupta

IPC分类号： A61B5/0476

CPC分类号： A61N1/36139 ,  A61B5/0476 ,  A61B5/0496 ,  A61M5/14276 ,  A61M2005/14208 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36132 ,  A61N1/36153 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36185 ,  A61N1/37247

摘要： Various embodiments concern sensing a LFP signal from one or more electrodes, measuring the amplitude of the signals over a period of time, and calculating a plurality of variance values from the amplitude, wherein each of the variance values correspond to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values. Such embodiments may further include assessing the relative level of neural activation of an area of the brain based on the variance values, wherein the area of the brain is assessed to have a relatively higher level of neural activation when the variance is relatively higher and the area of the brain is assessed to have a relatively lower level of neural activation when the variance is relatively lower.

摘要翻译： 各种实施例涉及感测来自一个或多个电极的LFP信号，在一段时间内测量信号的幅度，以及从幅度计算多个方差值，其中每个方差值对应于幅度的方差 相对于其他方差值的时间段的不同时间间隔。 这样的实施方案可以进一步包括基于方差值来评估脑区域的神经激活的相对水平，其中当方差相对较高时评估脑的面积具有相对较高水平的神经激活， 当方差相对较低时，脑的评估具有相对较低水平的神经激活。

公开(公告)号：US20120101547A1

公开(公告)日：2012-04-26

申请号：US13338751

申请日：2011-12-28

申请人： Steven L. Jensen ,  Dwight E. Nelson

发明人： Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/36

CPC分类号： A61N1/36146 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139

摘要： This disclosure describes techniques for delivering electrical stimulation at one or more phases relative to an ongoing oscillating signal in a patient, and then mapping the response to the oscillating signal. The techniques may reduce or eliminate the oscillating signal. In one example, the disclosure is directed to a method that includes delivering a set of first electrical stimulation at a plurality of phases relative to an oscillating signal, measuring a response in the oscillating signal to the set of first electrical stimulation after delivering electrical stimulation at each respective phase of the plurality of phases, determining a phase at which to deliver second electrical stimulation based on the measured responses, and delivering the second electrical stimulation to the patient at the determined phase to produce a therapeutic effect.

摘要翻译： 本公开描述了相对于患者中正在进行的振荡信号在一个或多个相位递送电刺激的技术，然后将响应映射到振荡信号。 这些技术可以减少或消除振荡信号。 在一个示例中，本公开涉及一种方法，其包括相对于振荡信号在多个相位递送一组第一电刺激，在将电刺激传递到第一电刺激之后测量振荡信号中的响应到第一电刺激 确定基于所测量的响应来传递第二电刺激的相位，以及在确定的阶段将第二电刺激递送给患者以产生治疗效果。

公开(公告)号：US08099170B2

公开(公告)日：2012-01-17

申请号：US12727889

申请日：2010-03-19

申请人： Steven L. Jensen ,  Dwight E. Nelson

发明人： Steven L. Jensen ,  Dwight E. Nelson

IPC分类号： A61N1/00

CPC分类号： A61N1/36146 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139

摘要： This disclosure describes techniques for delivering electrical stimulation at one or more phases relative to an ongoing oscillating signal in a patient, and then mapping the response to the oscillating signal. The techniques may reduce or eliminate the oscillating signal. In one example, the disclosure is directed to a method that includes delivering a set of first electrical stimulation at a plurality of phases relative to an oscillating signal, measuring a response in the oscillating signal to the set of first electrical stimulation after delivering electrical stimulation at each respective phase of the plurality of phases, determining a phase at which to deliver second electrical stimulation based on the measured responses, and delivering the second electrical stimulation to the patient at the determined phase to produce a therapeutic effect.

摘要翻译： 本公开描述了相对于患者中正在进行的振荡信号在一个或多个相位递送电刺激的技术，然后将响应映射到振荡信号。 这些技术可以减少或消除振荡信号。 在一个示例中，本公开涉及一种方法，其包括相对于振荡信号在多个相位递送一组第一电刺激，在将电刺激传递到第一电刺激之后测量振荡信号中的响应到第一电刺激 确定基于所测量的响应来传递第二电刺激的相位，以及在确定的阶段将第二电刺激递送给患者以产生治疗效果。