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    Methods and apparatus for improved administration of testosterone pharmaceuticals
    1.
    发明授权
    Methods and apparatus for improved administration of testosterone pharmaceuticals 失效
    用于改善睾丸激素药物施用的方法和装置

    公开(公告)号：US06726673B1

    公开(公告)日：2004-04-27

    申请号：US09317313

    申请日：1999-05-24

    申请人： Jie Zhang ,  Hao Zhang ,  Wade A. Hull ,  Larry Rigby

    发明人： Jie Zhang ,  Hao Zhang ,  Wade A. Hull ,  Larry Rigby

    IPC分类号： A61M3100

    CPC分类号： A61K9/0024 ,  A61F7/032 ,  A61K9/0009 ,  A61K9/7023 ,  A61M31/002 ,  A61M2037/0007 ,  A61N1/30

    摘要： The present invention relates to a method and apparatus for increasing the delivery rate of an androgen transdermal therapeutic system through the skin. An androgen transdermal therapeutic system can be applied to a patient's skin for delivery of the androgen. A temperature modification apparatus which is capable of generating controlled heat is applied approximate to the androgen transdermal therapeutic system. The heating from the temperature modification apparatus raises the temperature of the androgen transdermal therapeutic system and raises the temperature of the patient's skin to achieve an increased rate of delivery of androgen through the skin. The controlled heat can also be used to adjust dosage rates of the androgen transdermal therapeutic system and to mimic natural circadian patterns. The controlled heating may also be used to improve or regulate the release of androgen from injected/implanted extended/controlled release systems.

    摘要翻译： 本发明涉及通过皮肤增加雄激素透皮治疗系统的递送率的方法和装置。 雄激素透皮治疗系统可以应用于患者的皮肤以递送雄激素。 接近于雄激素透皮治疗系统的是能产生受控热量的温度调节装置。 来自温度改变装置的加热提高了雄激素透皮治疗系统的温度，并且提高了患者皮肤的温度，以达到通过皮肤递送雄激素的增加的速率。 受控热也可用于调节雄激素透皮治疗系统的剂量率，并模拟自然昼夜节律模式。 受控加热也可用于改善或调节注射/植入的扩增/控制释放系统中雄激素的释放。

    Method for manufacturing a heat generating apparatus
    2.
    发明授权
    Method for manufacturing a heat generating apparatus 有权
    制造发热装置的方法

    公开(公告)号：US06453648B1

    公开(公告)日：2002-09-24

    申请号：US09347963

    申请日：1999-07-06

    申请人： Jie Zhang ,  Hao Zhang ,  Larry Rigby ,  Wade A. Hull

    发明人： Jie Zhang ,  Hao Zhang ,  Larry Rigby ,  Wade A. Hull

    IPC分类号： A61F700

    CPC分类号： A61F7/034 ,  A61F2007/0226 ,  A61F2007/0249

    摘要： The present invention relates to a method for manufacturing a heating device which is capable of generating heat when exposed to oxygen. The heat generating element comprises activated carbon and iron is used to generate an exothermic oxidation reaction within the heating device. Introducing an oxidation inhibitor during the manufacturing process allows the manufacturing of the device to take place in ambient atmospheric conditions. The present invention also includes a loading facilitator which allows the heat generating medium to be more easily and efficiently loaded into the heat generating device. When appropriate, the oxidation inhibitor and loading facilitator can be removed.

    摘要翻译： 本发明涉及一种能够在暴露于氧气时产生热量的加热装置的制造方法。 发热元件包括活性炭和铁，用于在加热装置内产生放热氧化反应。 在制造过程中引入氧化抑制剂可使装置的制造在环境大气条件下进行。 本发明还包括能够使发热介质更容易且有效地装载到发热装置中的负载辅助装置。 适当时，可以除去氧化抑制剂和负载促进剂。

    SOLID-FORMING LOCAL ANESTHETIC FORMULATIONS FOR PAIN CONTROL
    4.
    发明申请
    SOLID-FORMING LOCAL ANESTHETIC FORMULATIONS FOR PAIN CONTROL 有权
    用于疼痛控制的固体局部麻醉制剂

    公开(公告)号：US20120022158A1

    公开(公告)日：2012-01-26

    申请号：US13006780

    申请日：2011-01-14

    申请人： Suyi Niu ,  Wade A. Hull ,  Jie Zhang

    发明人： Suyi Niu ,  Wade A. Hull ,  Jie Zhang

    IPC分类号： A61K31/245 ,  A61P23/02

    CPC分类号： A61K31/167 ,  A61K9/0014 ,  A61K31/136 ,  A61K47/32 ,  A61K2300/00

    摘要： Solid-forming local anesthetic formulations for pain control can include a lidocaine base and tetracaine base, polyvinyl alcohol, water, and an emulsifier. The formulation can be prepared to be in a semi-solid state prior to application to a skin surface, can form a soft solidified layer after application, and can provide pain relief when applied to a skin surface proximate a pain site.

    摘要翻译： 用于疼痛控制的固体形成局部麻醉剂制剂可以包括利多卡因碱和丁卡因碱，聚乙烯醇，水和乳化剂。 制剂可以在施用于皮肤表面之前制备成半固体状态，在施用后可以形成柔软的固化层，并且当施加到疼痛部位附近的皮肤表面时可以提供疼痛缓解。