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208 条记录 (耗时 0.034 秒)

    Methods and apparatus for improved administration of testosterone pharmaceuticals
    1.
    发明授权
    Methods and apparatus for improved administration of testosterone pharmaceuticals 失效
    用于改善睾丸激素药物施用的方法和装置

    公开(公告)号：US06726673B1

    公开(公告)日：2004-04-27

    申请号：US09317313

    申请日：1999-05-24

    申请人： Jie Zhang ,  Hao Zhang ,  Wade A. Hull ,  Larry Rigby

    发明人： Jie Zhang ,  Hao Zhang ,  Wade A. Hull ,  Larry Rigby

    IPC分类号： A61M3100

    CPC分类号： A61K9/0024 ,  A61F7/032 ,  A61K9/0009 ,  A61K9/7023 ,  A61M31/002 ,  A61M2037/0007 ,  A61N1/30

    摘要： The present invention relates to a method and apparatus for increasing the delivery rate of an androgen transdermal therapeutic system through the skin. An androgen transdermal therapeutic system can be applied to a patient's skin for delivery of the androgen. A temperature modification apparatus which is capable of generating controlled heat is applied approximate to the androgen transdermal therapeutic system. The heating from the temperature modification apparatus raises the temperature of the androgen transdermal therapeutic system and raises the temperature of the patient's skin to achieve an increased rate of delivery of androgen through the skin. The controlled heat can also be used to adjust dosage rates of the androgen transdermal therapeutic system and to mimic natural circadian patterns. The controlled heating may also be used to improve or regulate the release of androgen from injected/implanted extended/controlled release systems.

    摘要翻译： 本发明涉及通过皮肤增加雄激素透皮治疗系统的递送率的方法和装置。 雄激素透皮治疗系统可以应用于患者的皮肤以递送雄激素。 接近于雄激素透皮治疗系统的是能产生受控热量的温度调节装置。 来自温度改变装置的加热提高了雄激素透皮治疗系统的温度，并且提高了患者皮肤的温度，以达到通过皮肤递送雄激素的增加的速率。 受控热也可用于调节雄激素透皮治疗系统的剂量率，并模拟自然昼夜节律模式。 受控加热也可用于改善或调节注射/植入的扩增/控制释放系统中雄激素的释放。

    Method for manufacturing a heat generating apparatus
    3.
    发明授权
    Method for manufacturing a heat generating apparatus 有权
    制造发热装置的方法

    公开(公告)号：US06453648B1

    公开(公告)日：2002-09-24

    申请号：US09347963

    申请日：1999-07-06

    申请人： Jie Zhang ,  Hao Zhang ,  Larry Rigby ,  Wade A. Hull

    发明人： Jie Zhang ,  Hao Zhang ,  Larry Rigby ,  Wade A. Hull

    IPC分类号： A61F700

    CPC分类号： A61F7/034 ,  A61F2007/0226 ,  A61F2007/0249

    摘要： The present invention relates to a method for manufacturing a heating device which is capable of generating heat when exposed to oxygen. The heat generating element comprises activated carbon and iron is used to generate an exothermic oxidation reaction within the heating device. Introducing an oxidation inhibitor during the manufacturing process allows the manufacturing of the device to take place in ambient atmospheric conditions. The present invention also includes a loading facilitator which allows the heat generating medium to be more easily and efficiently loaded into the heat generating device. When appropriate, the oxidation inhibitor and loading facilitator can be removed.

    摘要翻译： 本发明涉及一种能够在暴露于氧气时产生热量的加热装置的制造方法。 发热元件包括活性炭和铁，用于在加热装置内产生放热氧化反应。 在制造过程中引入氧化抑制剂可使装置的制造在环境大气条件下进行。 本发明还包括能够使发热介质更容易且有效地装载到发热装置中的负载辅助装置。 适当时，可以除去氧化抑制剂和负载促进剂。

    Noninvasive dermal anesthetics
    9.
    发明授权
    Noninvasive dermal anesthetics 失效
    无创皮肤麻醉药

    公开(公告)号：US5919479A

    公开(公告)日：1999-07-06

    申请号：US819880

    申请日：1997-03-18

    申请人： Jie Zhang ,  Hao Zhang

    发明人： Jie Zhang ,  Hao Zhang

    IPC分类号： A61M37/00 ,  A61F7/02 ,  A61F7/03 ,  A61F13/00 ,  A61K9/70 ,  A61K31/167 ,  A61K31/245 ,  A61L15/42 ,  A61L15/44 ,  A61P23/00

    CPC分类号： A61F7/034 ,  A61K31/167 ,  A61K31/216 ,  A61K31/245 ,  A61K9/7023 ,  A61F2007/0261 ,  A61F2013/00187 ,  A61F2013/00204 ,  A61F2013/00906 ,  A61F2013/0091 ,  A61M37/00 ,  Y10S514/817 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/944

    摘要： An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-generating/temperature-regulating element is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effects. Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the drug formulation reservoir between the non-permeable wall and the user's skin surface for maintaining a predetermined thickness of the drug formulation on the user's skin surface. Also, a novel product formulation which can be used with the apparatus which uses high percentage of eutectic mixture of local anesthetics to reduce the overall degradation rate of the local anesthetic compound(s) in formulations which are subject to hydrolysis.

    摘要翻译： 一种用于改善药物皮肤渗透的装置，产品制剂和方法，其中所述装置包括薄的药物制剂储存器和由第一不可渗透壁分隔开的发热室，其中所述储存器和室由 住房。 药物制剂储存器容纳或能够容纳预定量的含有药物活性剂的制剂。 发热/温度调节室包括用于产生受控热的介质，优选由碳，铁，水和/或盐制成的化学组成，其在与空气（氧气）接触时被活化。 发热/温度调节元件的功能是加热使用者的皮肤，迅速使皮肤温度达到所需和升高的窄范围，并将其保持在该范围内足够的时间以获得更快速，增强和更少变化的皮肤 吸收所选的药物活性剂并获得改善的临床效果。 还公开了用于控制发热的结构。 该装置可以可选地包括跨越药物制剂储存器在不可渗透的壁和使用者的皮肤表面之间的间隔或间隔结构，用于维持用户皮肤表面上的药物制剂的预定厚度。 另外，可以与使用高百分比的局部麻醉剂共晶混合物的装置一起使用的新产品制剂来降低在待水解的制剂中的局部麻醉剂的总体降解速率。

    Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals
    10.
    发明授权
    Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals 失效
    用于改善药物非侵入性皮肤给药的装置和方法

    公开(公告)号：US5658583A

    公开(公告)日：1997-08-19

    申请号：US508463

    申请日：1995-07-28

    申请人： Jie Zhang ,  Hao Zhang

    发明人： Jie Zhang ,  Hao Zhang

    IPC分类号： A61M37/00 ,  A61F7/02 ,  A61F7/03 ,  A61F13/00 ,  A61K9/70 ,  A61K31/167 ,  A61K31/245 ,  A61L15/42 ,  A61L15/44 ,  A61P23/00 ,  A01N25/34

    CPC分类号： A61F7/034 ,  A61K31/167 ,  A61K31/216 ,  A61K31/245 ,  A61K9/7023 ,  A61F2007/0261 ,  A61F2013/00187 ,  A61F2013/00204 ,  A61F2013/00906 ,  A61F2013/0091 ,  A61M37/00 ,  Y10S514/817 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/944

    摘要： An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-generating/temperature-regulating element is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effects. Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the drug formulation reservoir between the non-permeable wall and the user's skin surface for maintaining a predetermined thickness of the drug formulation on the user's skin surface. Also, a novel product formulation which can be used with the apparatus which uses high percentage of eutectic mixture of local anesthetics to reduce the overall degradation rate of the local anesthetic compound(s) in formulations which are subject to hydrolysis.

    摘要翻译： 一种用于改善药物皮肤渗透的装置，产品制剂和方法，其中所述装置包括薄的药物制剂储存器和由第一不可渗透壁分隔开的发热室，其中所述储存器和室由 住房。 药物制剂储存器容纳或能够容纳预定量的含有药物活性剂的制剂。 发热/温度调节室包括用于产生受控热的介质，优选由碳，铁，水和/或盐制成的化学组成，其在与空气（氧气）接触时被活化。 发热/温度调节元件的功能是加热使用者的皮肤，迅速使皮肤温度达到所需和升高的窄范围，并将其保持在该范围内足够的时间以获得更快速，增强和更少变化的皮肤 吸收所选的药物活性剂并获得改善的临床效果。 还公开了用于控制发热的结构。 该装置可以可选地包括跨越药物制剂储存器在不可渗透的壁和使用者的皮肤表面之间的间隔或间隔结构，用于维持用户皮肤表面上的药物制剂的预定厚度。 另外，可以与使用高百分比的局部麻醉剂共晶混合物的装置一起使用的新产品制剂来降低在待水解的制剂中的局部麻醉剂的总体降解速率。