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12 条记录 (耗时 0.028 秒)

    Methods and apparatus for improved administration of testosterone pharmaceuticals
    2.
    发明授权
    Methods and apparatus for improved administration of testosterone pharmaceuticals 失效
    用于改善睾丸激素药物施用的方法和装置

    公开(公告)号：US06726673B1

    公开(公告)日：2004-04-27

    申请号：US09317313

    申请日：1999-05-24

    申请人： Jie Zhang ,  Hao Zhang ,  Wade A. Hull ,  Larry Rigby

    发明人： Jie Zhang ,  Hao Zhang ,  Wade A. Hull ,  Larry Rigby

    IPC分类号： A61M3100

    CPC分类号： A61K9/0024 ,  A61F7/032 ,  A61K9/0009 ,  A61K9/7023 ,  A61M31/002 ,  A61M2037/0007 ,  A61N1/30

    摘要： The present invention relates to a method and apparatus for increasing the delivery rate of an androgen transdermal therapeutic system through the skin. An androgen transdermal therapeutic system can be applied to a patient's skin for delivery of the androgen. A temperature modification apparatus which is capable of generating controlled heat is applied approximate to the androgen transdermal therapeutic system. The heating from the temperature modification apparatus raises the temperature of the androgen transdermal therapeutic system and raises the temperature of the patient's skin to achieve an increased rate of delivery of androgen through the skin. The controlled heat can also be used to adjust dosage rates of the androgen transdermal therapeutic system and to mimic natural circadian patterns. The controlled heating may also be used to improve or regulate the release of androgen from injected/implanted extended/controlled release systems.

    摘要翻译： 本发明涉及通过皮肤增加雄激素透皮治疗系统的递送率的方法和装置。 雄激素透皮治疗系统可以应用于患者的皮肤以递送雄激素。 接近于雄激素透皮治疗系统的是能产生受控热量的温度调节装置。 来自温度改变装置的加热提高了雄激素透皮治疗系统的温度，并且提高了患者皮肤的温度，以达到通过皮肤递送雄激素的增加的速率。 受控热也可用于调节雄激素透皮治疗系统的剂量率，并模拟自然昼夜节律模式。 受控加热也可用于改善或调节注射/植入的扩增/控制释放系统中雄激素的释放。

    Method for manufacturing a heat generating apparatus
    3.
    发明授权
    Method for manufacturing a heat generating apparatus 有权
    制造发热装置的方法

    公开(公告)号：US06453648B1

    公开(公告)日：2002-09-24

    申请号：US09347963

    申请日：1999-07-06

    申请人： Jie Zhang ,  Hao Zhang ,  Larry Rigby ,  Wade A. Hull

    发明人： Jie Zhang ,  Hao Zhang ,  Larry Rigby ,  Wade A. Hull

    IPC分类号： A61F700

    CPC分类号： A61F7/034 ,  A61F2007/0226 ,  A61F2007/0249

    摘要： The present invention relates to a method for manufacturing a heating device which is capable of generating heat when exposed to oxygen. The heat generating element comprises activated carbon and iron is used to generate an exothermic oxidation reaction within the heating device. Introducing an oxidation inhibitor during the manufacturing process allows the manufacturing of the device to take place in ambient atmospheric conditions. The present invention also includes a loading facilitator which allows the heat generating medium to be more easily and efficiently loaded into the heat generating device. When appropriate, the oxidation inhibitor and loading facilitator can be removed.

    摘要翻译： 本发明涉及一种能够在暴露于氧气时产生热量的加热装置的制造方法。 发热元件包括活性炭和铁，用于在加热装置内产生放热氧化反应。 在制造过程中引入氧化抑制剂可使装置的制造在环境大气条件下进行。 本发明还包括能够使发热介质更容易且有效地装载到发热装置中的负载辅助装置。 适当时，可以除去氧化抑制剂和负载促进剂。

    Transdermal drug patch with attached pocket for controlled heating device
    4.
    发明授权
    Transdermal drug patch with attached pocket for controlled heating device 失效

    公开(公告)号：US06488959B2

    公开(公告)日：2002-12-03

    申请号：US09864472

    申请日：2001-05-24

    申请人： Theodore Stanley ,  Wade Hull ,  Larry Rigby ,  Jie Zhang

    发明人： Theodore Stanley ,  Wade Hull ,  Larry Rigby ,  Jie Zhang

    IPC分类号： A61F1300

    CPC分类号： A61K9/7084 ,  A61N1/30

    摘要： The present invention relates to a transdermal drug delivery system comprising a dermal drug delivery patch and a heating element compartment securable to the dermal drug delivery patch. A freely transferrable heating element is securable within the heating element compartment. A drug can be administered transdermally using the present invention by placing the dermal drug delivery patch upon a patient's skin at an administration site. A heating element compartment is secured to the dermal drug delivery patch and a freely transferrable heating element is placed within the heating element compartment. The heating element provides controlled heat to the dermal drug patch and the patient's skin and thereby improves dermal drug administration.

    METHODS FOR TREATING MYOFASCIAL, MUSCLE, AND/OR BACK PAIN
    7.
    发明申请
    METHODS FOR TREATING MYOFASCIAL, MUSCLE, AND/OR BACK PAIN 审中-公开
    治疗肌肉，肌肉和/或背部疼痛的方法

    公开(公告)号：US20110086913A1

    公开(公告)日：2011-04-14

    申请号：US12752384

    申请日：2010-04-01

    申请人： Jie Zhang ,  Andrew Crockett ,  Larry Rigby

    发明人： Jie Zhang ,  Andrew Crockett ,  Larry Rigby

    IPC分类号： A61K31/24 ,  A61K31/167 ,  A61P29/00

    CPC分类号： A61K9/0004 ,  A61F7/034 ,  A61F2007/0226 ,  A61F2007/0257 ,  A61F2007/0261 ,  A61K9/7084

    摘要： The present disclosure is drawn to methods for treating myofascial pain, muscle pain, back pain, or combinations of these pains. Specifically, a method for treating myofascial pain, muscle pain, back pain, or combinations thereof includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36° C. to 42° C.

    摘要翻译： 本公开涉及用于治疗肌筋膜疼痛，肌肉疼痛，背部疼痛或这些疼痛的组合的方法。 具体而言，治疗肌筋膜疼痛，肌肉疼痛，背部疼痛或其组合的方法包括将镇痛系统施用于经历疼痛的受试者的皮肤表面，并将止痛系统保持在皮肤表面上一段时间 至少30分钟。 应用于皮肤表面的镇痛系统可以包括加热组分和包括至少一种局部麻醉剂的局部麻醉剂制剂。 加热部件能够将皮肤表面加热至36℃至42℃的温度。

    Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
    8.
    发明申请
    Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same 有权
    用于皮肤递送药物的粘合剂剥离形成剂及其使用方法

    公开(公告)号：US20050276842A1

    公开(公告)日：2005-12-15

    申请号：US11146917

    申请日：2005-06-06

    申请人： Jie Zhang ,  Kevin Warner ,  Michael Ashburn ,  Larry Rigby ,  Suyi Niu

    发明人： Jie Zhang ,  Kevin Warner ,  Michael Ashburn ,  Larry Rigby ,  Suyi Niu

    IPC分类号： A61K9/70

    CPC分类号： A61K9/7015 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/445 ,  A61K31/573 ,  A61K47/10 ,  A61K47/32

    摘要： The present invention is drawn to adhesive peel-forming formulations for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a peel-forming agent. The solvent vehicle can include a volatile solvent system having one or more volatile solvent, and a non-volatile solvent system having one or more non-volatile solvent, wherein the non-volatile solvent system has a solubility for the drug that is within a window of operable solubility for the drug such that the drug can be delivered at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified peelable layer after at least a portion of the volatile solvent system is evaporated.

    摘要翻译： 本发明涉及用于药物真皮递送的粘合剂剥离形成制剂。 制剂可以包括药物，溶剂载体和剥离形成剂。 溶剂载体可以包括具有一种或多种挥发性溶剂的挥发性溶剂体系和具有一种或多种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系对于在窗口内的药物具有溶解性 对药物具有可操作的溶解性，使得药物可以在持续的时间段内以治疗有效率递送。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发之后，制剂可以形成固化的可剥离层。

    Multi-functional endoscopic probe apparatus
    10.
    发明授权
    Multi-functional endoscopic probe apparatus 失效
    多功能内窥镜探头设备

    公开(公告)号：US5254117A

    公开(公告)日：1993-10-19

    申请号：US854108

    申请日：1992-03-17

    申请人： Larry Rigby ,  Eric Steckel ,  Dixon Ford

    发明人： Larry Rigby ,  Eric Steckel ,  Dixon Ford

    IPC分类号： A61B17/28 ,  A61B18/00 ,  A61B18/14 ,  A61M1/00 ,  A61B17/36

    CPC分类号： A61B18/1482 ,  A61M1/0045 ,  A61M1/0064 ,  A61B2017/2929 ,  A61B2018/00083 ,  A61B2018/00916 ,  A61B2018/1861 ,  A61B2218/002 ,  A61B2218/007

    摘要： A multi-functional endoscopic probe apparatus to selectively apply either a low or high frequency voltage to cut and cauterize. The apparatus has an elongated multi-lumen tube that is attached to a pistol grip having a multiplicity of functions contained thereon. The multi-lumen tube has a first lumen for the passage of either a high or a low pressure irrigation stream therethrough, a second lumen for suction to remove excess fluid and debris, and a third lumen for the passage of a slidably extendable and retractable electro-surgical cutting tip. The pistol grip handle has a wheel which enables the surgeon to rotate the multi-lumen tube containing the surgical cutting tip relative to the pistol grip. A plurality of push-button valves enable the selective application a negative pressure for withdrawing excess fluids and removing incident tissue debris from the surgical site and to operatively apply a flood irrigation stream or a precise irrigation stream to the surgical site to wash and cleanse the tissue. A multi-position electric switch directs either a low or a high frequency voltage to an electro-surgical cutting tip in order to cut and/or cauterized the tissue in contact therewith.

    摘要翻译： 一种多功能内窥镜探针装置，用于选择性地施加低频或高频电压以切割和烧灼。 该装置具有细长的多腔管，其连接到具有多个功能的手枪把手上。 多腔管具有用于高压或低压冲洗流通过的第一腔，用于抽吸以除去多余的流体和碎屑的第二腔，以及用于通过可滑动延伸和可缩回电 手术切割尖。 手枪握柄具有轮，其能够使外科医生相对于手枪把手旋转包含手术切割尖端的多腔管。 多个按钮阀使得能够选择性地施加负压用于抽出多余的流体并从外科手术部位移除入侵的组织碎屑，并且可操作地将冲洗流或精确的冲洗流施加到手术部位以洗涤和清洁组织 。 多位置电开关将低频或高频电压引导到电切割尖端，以便与其接触的组织切割和/或烧灼。