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1.Toll Like Receptor 3 Antagonists, Methods and Uses 审中-公开
标题翻译: Toll Like Receptor 3 Antagonists,Methods and Uses公开(公告)号:US20120189643A1
公开(公告)日:2012-07-26
申请号:US13412259
申请日:2012-03-05
申请人: Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人: Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
IPC分类号: A61K39/395 , C12N15/13 , C12N15/63 , C12N1/21 , A61P3/10 , C12P21/00 , C12N5/16 , A61P29/00 , A61P1/00 , A61P11/00 , C07K16/28 , C12N5/10
CPC分类号: C07K16/2866 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/74 , C07K2317/76
摘要: Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
摘要翻译: Toll样受体3(TLR3)拮抗剂,编码TLR3拮抗剂或其片段的多核苷酸,以及制备和使用前述物质的方法。
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公开(公告)号:US08153583B2
公开(公告)日:2012-04-10
申请号:US11291140
申请日:2005-11-30
申请人: Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
发明人: Jill M. Carton , Shizhong Chen , Mark Cunningham , Anuk Das , Karen Duffy , Jill M. Giles-Komar , Theresa J. Goletz , David M. Knight , Roberta Lamb , Mouhamadou L. Mbow , Kristen Picha , Gopalan Raghunathan , Lani San Mateo , Robert T. Sarisky , Vedrana Stojanovic-Susulic , Nicole Stowell , Raymond Sweet , Shanrong Zhao
CPC分类号: C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要: Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists, and methods of making and using the foregoing are disclosed.
摘要翻译: 公开了Toll样受体3(TLR3)拮抗剂,编码TLR3拮抗剂的多核苷酸,以及制备和使用前述物质的方法。
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公开(公告)号:US20120308573A1
公开(公告)日:2012-12-06
申请号:US13587370
申请日:2012-08-16
申请人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
发明人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
IPC分类号: C07K16/24 , A61P9/00 , A61P27/02 , A61P11/00 , A61P1/00 , A61P35/00 , A61K39/395 , A61P25/00
CPC分类号: A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译: 抗IL-23抗体,包括编码至少一种抗IL-23抗体,载体,宿主细胞,转基因动物或植物的分离的核酸及其制备和使用的方法具有诊断和/或治疗组合物中的应用 ,方法和设备。
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公开(公告)号:US07491391B2
公开(公告)日:2009-02-17
申请号:US11479464
申请日:2006-06-30
申请人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
发明人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
IPC分类号: A61K39/395 , C07K16/24
CPC分类号: A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译: 抗IL-23p19抗体,包括编码至少一种抗IL-23p19抗体的分离的核酸,载体,宿主细胞,转基因动物或植物及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ,方法和设备。
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公开(公告)号:US08574579B2
公开(公告)日:2013-11-05
申请号:US13587370
申请日:2012-08-16
申请人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
发明人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
IPC分类号: A61K39/395 , C07K16/24
CPC分类号: A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译: 抗IL-23抗体,包括编码至少一种抗IL-23抗体,载体,宿主细胞,转基因动物或植物的分离的核酸及其制备和使用的方法具有诊断和/或治疗组合物中的应用 ,方法和设备。
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6.METHODS FOR GENERATING ANTI-IL-23 ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
标题翻译: 用于产生抗IL-23抗体,组合物,方法和用途的方法公开(公告)号:US20110319292A1
公开(公告)日:2011-12-29
申请号:US13231537
申请日:2011-09-13
申请人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
发明人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
CPC分类号: A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要: A protein variant of IL-23p19 that has conserved residues in positions 93-102, 93-110, and/or 127-137 of SEQ ID NO:1, can be used to generate anti-IL-23p19 antibodies.
摘要翻译: 具有SEQ ID NO:1的93-102,93-110和/或127-137位的保守残基的IL-23p19的蛋白质变体可用于产生抗IL-23p19抗体。
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公开(公告)号:US07807414B2
公开(公告)日:2010-10-05
申请号:US12370872
申请日:2009-02-13
申请人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
发明人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
CPC分类号: A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译: 抗IL-23p19抗体,包括编码至少一种抗IL-23p19抗体的分离的核酸,载体,宿主细胞,转基因动物或植物及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ,方法和设备。
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公开(公告)号:US20090162371A1
公开(公告)日:2009-06-25
申请号:US12370872
申请日:2009-02-13
申请人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
发明人: Jacqueline Benson , Mark Cunningham , Cynthia Duchala , Jill M. Giles-Komar , Jinquan Luo , Michael A. Rycyzyn , Sweet Raymond
IPC分类号: A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N1/21 , C12N5/06 , C12P21/02 , G01N33/53
CPC分类号: A61K39/3955 , A61K39/00 , A61K45/06 , A61K2039/505 , A61K2039/55527 , A61K2039/55544 , C07K16/244 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/55 , G01N33/6869 , G01N2333/54 , Y02A50/386 , Y02A50/401 , Y02A50/41 , Y02A50/412 , Y02A50/55 , Y02A50/57 , Y02A50/58
摘要: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译: 抗IL-23p19抗体,包括编码至少一种抗IL-23p19抗体的分离的核酸,载体,宿主细胞,转基因动物或植物及其制备和使用的方法具有在诊断和/或治疗组合物中的应用 ,方法和设备。
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公开(公告)号:US20080286289A1
公开(公告)日:2008-11-20
申请号:US12091814
申请日:2006-10-27
IPC分类号: C07K16/18 , A01K67/027 , A61K39/395 , G01N33/53 , A61P43/00
CPC分类号: C07K16/00 , A61K39/395 , C07K16/244 , C07K16/2878 , C07K2317/75 , A61K2300/00
摘要: A method for efficiently generating antibodies immunizes an animal with a target antigen and a B cell expansion agent, such as an anti-CD40 agonist. The antibodies generated from this method are useful as therapeutic agents, diagnostic agents or research reagents in a variety of diseases and conditions.
摘要翻译: 有效产生抗体的方法用靶抗原和B细胞扩增剂如抗CD40激动剂免疫动物。 从该方法产生的抗体可用作各种疾病和病症中的治疗剂,诊断剂或研究试剂。
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公开(公告)号:US20110200613A1
公开(公告)日:2011-08-18
申请号:US13093369
申请日:2011-04-25
IPC分类号: A61K39/395 , C07K1/14 , A61K39/00 , C07K16/00 , C07K16/24 , A61P37/04 , A61P9/00 , A61P31/00 , A61P1/00 , A61P25/00 , A61P3/12 , A61P27/02 , A61P27/16 , A61P11/02 , A61P37/02 , A61P11/00
CPC分类号: C07K16/00 , A61K39/395 , C07K16/244 , C07K16/2878 , C07K2317/75 , A61K2300/00
摘要: A method for efficiently generating antibodies immunizes an animal with a target antigen and a B cell expansion agent, such as an anti-CD40 agonist. The antibodies generated from this method are useful as therapeutic agents, diagnostic agents or research reagents in a variety of diseases and conditions.
摘要翻译: 有效产生抗体的方法用靶抗原和B细胞扩增剂如抗CD40激动剂免疫动物。 从该方法产生的抗体可用作各种疾病和病症中的治疗剂,诊断剂或研究试剂。
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