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公开(公告)号：US20220151924A1
公开(公告)日：2022-05-19
申请号：US17434363
申请日：2020-02-27
申请人： C. Jeffrey Brinker , Jimin Guo , Wei Zhu
发明人： C. Jeffrey Brinker , Jimin Guo , Wei Zhu
IPC分类号： A61K9/107 , A61K33/242 , A61K47/69 , A61P35/00 , A61K47/68 , A61K47/10 , A61K47/24 , A61K31/704
摘要： A method to prepare a population of metal-organic polyhedra (MOP) supported micelle nanoparticles (NPs), and a composition comprising MOP supported micelle NPs, are provided.
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公开(公告)号：US20220033768A1
公开(公告)日：2022-02-03
申请号：US17277256
申请日：2019-09-24
申请人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu , Jacob Ongudi Agola
发明人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu , Jacob Ongudi Agola
摘要： An encapsulated living (viable) mammalian cell, and methods of making and using that cell, are provided.
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公开(公告)号：US20220033767A1
公开(公告)日：2022-02-03
申请号：US17277260
申请日：2019-09-24
申请人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu
发明人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu
IPC分类号： C12N5/00 , C12N5/078 , C12N5/0789 , A61K47/69
摘要： A modified vertebrate cell comprising a vertebrate cell encased in reversibly interlinked metal-organic framework (MOF) nanoparticles, and methods of making and using the modified cell, are provided.
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公开(公告)号：US20210386055A1
公开(公告)日：2021-12-16
申请号：US17309152
申请日：2019-10-30
申请人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu
发明人： Jimin Guo , C. Jeffrey Brinker , Wei Zhu
摘要： Zr-based MOF NPs for cryopreservation of cells including, for example, red blood cells.
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公开(公告)号：US20200276286A1
公开(公告)日：2020-09-03
申请号：US16647245
申请日：2018-09-13
申请人： Rita E. Serda , C. Jeffrey Brinker , Jacob Ongudi Agola , Jimin Guo , Sarah Adams , STC.UNM
摘要： A silicified cell replica includes a silicified cell or a silicified subcellular fragment. The silicified cell replica may be used to induce an immunological response, treat a bacterial infection, or treat a patient with cancer.
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公开(公告)号：US20210315822A1
公开(公告)日：2021-10-14
申请号：US17264452
申请日：2019-07-30
摘要： Methods of preparing red blood cell mimetics and functionalized red blood cell mimetics, and methods of making and using those mimetics, are provided.
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公开(公告)号：US20220125835A1
公开(公告)日：2022-04-28
申请号：US17436872
申请日：2020-03-03
发明人： Rita E. Serda , Jimin Guo
摘要： A pharmaceutical composition includes a silicified cell or fraction thereof, a cationic layer disposed on at least a portion of the surface of the silicified cell or fraction thereof, and an immunomodulatory moiety bound to at least a portion of the cationic layer. Alternatively, the pharmaceutical composition includes a silicified cell or fraction thereof, a cationic layer disposed on at least a portion of the surface of the silicified cell or fraction thereof, an anionic layer disposed on at least a portion of the cationic layer, and an immunomodulatory moiety bound to at least a portion of the anionic layer.
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公开(公告)号：US20230149456A1
公开(公告)日：2023-05-18
申请号：US17916193
申请日：2021-03-30
申请人： Rita E. Serda , Jimin Guo , Achraf Noureddine , Stefan A. Franco , Henning DeMay , UNM RAINFOREST INNOVATIONS
发明人： Rita E. Serda , Jimin Guo , Achraf Noureddine , Stefan A. Franco , Henning DeMay
摘要： A silicified cell includes a nanoparticle that carries a bioactive agent. The silicified call can be a tumor cell, a bacterial cell, a virus, or a silicifiable compartment or fragment thereof. The silicified cell can optionally include an immunomodulatory moiety that may be carried within pores of the nanoparticle and/or bound to the surface of the nanoparticle. The silicified cell can be used as a prophylactic or therapeutic treatment for treating tumors or bacterial infections.
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