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1.发明申请NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME 有权新型多巴胺D3受体配体及其制备和医疗用途公开(公告)号：US20110319423A1
公开(公告)日：2011-12-29
申请号：US13123368
申请日：2009-09-28
申请人： Jin Li , Rifang Yang , Rui Song , Hui Zhu , Ning Wu , Liuhong Yun , Ruibin Su , Rusheng Zhao
发明人： Jin Li , Rifang Yang , Rui Song , Hui Zhu , Ning Wu , Liuhong Yun , Ruibin Su , Rusheng Zhao
IPC分类号： A61K31/496 , A61P25/18 , A61P13/12 , A61P25/36 , A61P25/22 , A61P15/10 , C07D417/12 , A61P25/16
CPC分类号： A61K31/496 , C07D263/58 , C07D277/68 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to a novel piperazine derivative represented by Formula I having an activity for regulating dopamine D3 receptor, stereoisomers thereof, pharmaceutically acceptable salts or solvates, and a pharmaceutical composition comprising the compound, a process for preparing the same, and use thereof in the prevention or treatment of a disease associated with central nervous system dysfunction, such as Parkinson's disease, schizophrenia, drug addiction and relapse, as well as kidney protection and immunoregulation, or as a tool for researching D3R function or diseases associated with D3R dysfunction.
摘要翻译： 本发明涉及由式I表示的具有调节多巴胺D3受体活性的新型哌嗪衍生物，其立体异构体，药学上可接受的盐或溶剂合物，以及包含该化合物的药物组合物，其制备方法及其用途 预防或治疗与中枢神经系统功能障碍相关的疾病，例如帕金森病，精神分裂症，药物成瘾和复发，以及肾脏保护和免疫调节，或用作研究D3R功能或与D3R功能障碍相关的疾病的工具。
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2.发明授权公开(公告)号：US08829001B2
公开(公告)日：2014-09-09
申请号：US13123368
申请日：2009-09-28
申请人： Jin Li , Rifang Yang , Rui Song , Hui Zhu , Ning Wu , Liuhong Yun , Ruibin Su , Rusheng Zhao
发明人： Jin Li , Rifang Yang , Rui Song , Hui Zhu , Ning Wu , Liuhong Yun , Ruibin Su , Rusheng Zhao
IPC分类号： A61K31/496 , A61K31/506 , C07D263/58 , C07D277/68 , C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： A61K31/496 , C07D263/58 , C07D277/68 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to a novel piperazine derivative represented by Formula I having an activity for regulating dopamine D3 receptor, stereoisomers thereof, pharmaceutically acceptable salts or solvates, and a pharmaceutical composition comprising the compound, a process for preparing the same, and use thereof in the prevention or treatment of a disease associated with central nervous system dysfunction, such as Parkinson's disease, schizophrenia, drug addiction and relapse, as well as kidney protection and immunoregulation, or as a tool for researching D3R function or diseases associated with D3R dysfunction.
摘要翻译： 本发明涉及由式I表示的具有调节多巴胺D3受体活性的新型哌嗪衍生物，其立体异构体，药学上可接受的盐或溶剂合物，以及包含该化合物的药物组合物，其制备方法及其用途 预防或治疗与中枢神经系统功能障碍相关的疾病，例如帕金森病，精神分裂症，药物成瘾和复发，以及肾脏保护和免疫调节，或用作研究D3R功能或与D3R功能障碍相关的疾病的工具。
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公开(公告)号：US10853900B2
公开(公告)日：2020-12-01
申请号：US12638847
申请日：2009-12-15
申请人： Jun Hua , Hui Zhu , Catherine V. Orate-Pott , David Shellenberger , Deonadayalan Narayanaswamy , Niranjan A. Shetty
发明人： Jun Hua , Hui Zhu , Catherine V. Orate-Pott , David Shellenberger , Deonadayalan Narayanaswamy , Niranjan A. Shetty
摘要： Data characterizing an individual is received. Thereafter, one or more variables are extracted from the data so that, using a predictive model populated with the extracted variables, a likelihood of the individual adhering to a treatment regimen can be determined. The predictive model is trained on historical treatment regimen adherence data empirically derived from a plurality of subjects. Subsequently, data characterizing the determined likelihood of adherence can be promoted. Related apparatus, systems, techniques and articles are also described.
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公开(公告)号：US20130159453A1
公开(公告)日：2013-06-20
申请号：US13325482
申请日：2011-12-14
申请人： Michael McLean , Smith Codio , Jeffrey Wall , Sonal Jain , Chythanya Vootkuri Krishna , Hui Zhu , Michel Abraham , Robert Kennedy Murugan
发明人： Michael McLean , Smith Codio , Jeffrey Wall , Sonal Jain , Chythanya Vootkuri Krishna , Hui Zhu , Michel Abraham , Robert Kennedy Murugan
IPC分类号： G06F15/16
CPC分类号： G06F9/5072
摘要： A pre-provisioned application platform may be provided. First, a plurality of parameters may be received. Then a plurality of pre-provisioned tenants may be created based upon the received plurality of parameters. A request for service may be received and then an actual tenant may be assigned to one of the plurality of pre-provisioned tenants in response to the received request.
摘要翻译： 可以提供预先配置的应用平台。 首先，可以接收多个参数。 然后，可以基于所接收的多个参数来创建多个预先提供的租户。 可以接收服务请求，然后可以响应于接收到的请求将实际租户分配给多个预先提供的租户之一。
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5.发明授权Methods of detecting mutations associated with ataxia-ocular apraxia 2 (AOA2) 有权检测与共济失调 - 眼睛不适2（AOA2）相关突变的方法公开(公告)号：US08192933B2
公开(公告)日：2012-06-05
申请号：US12722078
申请日：2010-03-11
申请人： Corey D. Braastad , Narasimhan Nagan , Jeffrey G. Jones , William K. Seltzer , Susan Allen , Sat Dev Batish , Hui Zhu
发明人： Corey D. Braastad , Narasimhan Nagan , Jeffrey G. Jones , William K. Seltzer , Susan Allen , Sat Dev Batish , Hui Zhu
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
摘要翻译： 描述了与共济失调 - 眼睛不适2（AOA2）相关的多态性鉴定方法。 与AOA2相关的多态性包括senataxin（SETX）基因中的特异性突变。 还描述了诊断AOA2的方法，以及评估个体对于AOA2的载体状态的方法。
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6.发明授权Methods of detecting mutations associated with ataxia-ocular apraxia 2 (AOA2) 有权检测与共济失调 - 眼睛不适2（AOA2）相关突变的方法公开(公告)号：US07704691B2
公开(公告)日：2010-04-27
申请号：US11656350
申请日：2007-01-22
申请人： Corey D. Braastad , Narasimhan Nagan , Jeffrey G. Jones , William K. Seltzer , Susan Allen , Sat Dev Batish , Hui Zhu
发明人： Corey D. Braastad , Narasimhan Nagan , Jeffrey G. Jones , William K. Seltzer , Susan Allen , Sat Dev Batish , Hui Zhu
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： Methods of identifying polymorphisms associated with ataxia-ocular apraxia 2 (AOA2), are described. The polymorphisms associated with AOA2 include specific mutations in the senataxin (SETX) gene. Also described are methods of diagnosis of AOA2, as well as methods of assessing an individual for carrier status for AOA2.
摘要翻译： 描述了与共济失调 - 眼睛不适2（AOA2）相关的多态性鉴定方法。 与AOA2相关的多态性包括senataxin（SETX）基因中的特异性突变。 还描述了诊断AOA2的方法，以及评估个体对于AOA2的载体状态的方法。
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公开(公告)号：US06187380B1
公开(公告)日：2001-02-13
申请号：US08995495
申请日：1997-12-22
申请人： Robert W. Hallman , Hui Zhu , Ken-Ichi Shimazu , S. Peter Pappas
发明人： Robert W. Hallman , Hui Zhu , Ken-Ichi Shimazu , S. Peter Pappas
IPC分类号： B41N108
CPC分类号： G03F7/2018 , B41C1/1066
摘要： A presensitized printing plate intermediate having an image mask on a UV radiation transparent removable coating layer; and a printing plate produced directly by reactants which polymerize alone or in combination with other reactants precoated on the plate substrate to form a printable hard resin image. A method of digitally forming an image on said printing plate intermediate.
摘要翻译： 一种在UV辐射透明可移除涂层上具有图像掩模的预敏印刷版中间体; 以及直接由反应物制备的印版，其单独聚合或与预先涂覆在印版基材上的其它反应物组合形成可印刷的硬树脂图像。 一种在所述印版中间数字形成图像的方法。
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公开(公告)号：US6143470A
公开(公告)日：2000-11-07
申请号：US494617
申请日：1995-06-23
申请人： My T. Nguyen , Hui Zhu , S. Peter Pappas , Ken-ichi Shimazu , Robert W. Hallman
发明人： My T. Nguyen , Hui Zhu , S. Peter Pappas , Ken-ichi Shimazu , Robert W. Hallman
CPC分类号： G03F7/202 , B41C1/1033 , B41C2210/16
摘要： Lithographic printing plates for wet or waterless offset printing are disclosed which can be imagewise exposed using a digitally controlled IR laser. The invention comprises a laser imagable lithographic printing plate comprising a substrate, a photosensitive coating on the substrate, and a water soluble laser ablatable top coating containing dyes or polymers that absorb infra-red, ultraviolet and visible light. Laminated transparent polymer films and/or peelable polymeric coatings films can be interposed between the coated substrate and a water soluble and/or organic solvent soluble laser ablatable top layer to augment plate production or image inscription on the plate.
摘要翻译： 公开了用于湿或无水胶版印刷的平版印刷版，其可以使用数字控制的IR激光成像曝光。 本发明包括一种可激光成像的平版印刷版，其包括基底，基底上的感光涂层和含有吸收红外，紫外和可见光的染料或聚合物的水溶性激光可消泡顶涂层。 层压的透明聚合物膜和/或可剥离的聚合物涂层膜可以插入涂覆的基底和水溶性和/或有机溶剂可溶的激光可烧蚀顶层之间，以增加板上的板材生产或图像铭文。
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公开(公告)号：US08284767B2
公开(公告)日：2012-10-09
申请号：US12776309
申请日：2010-05-07
申请人： Zhiquan Yi , Guihua Li , Hongjin Yuan , Hui Zhu , Qingchun Shen , Liyan Song
发明人： Zhiquan Yi , Guihua Li , Hongjin Yuan , Hui Zhu , Qingchun Shen , Liyan Song
IPC分类号： H04L12/66
CPC分类号： H04L65/104 , H04L65/103 , H04L65/1063 , H04L65/1069 , H04M3/42263 , H04M7/123 , H04M7/1235 , H04W80/10
摘要： A call processing method, a call processing system and call processing equipment of a same number service are disclosed. The method includes: receiving a call which is initiated by a calling client and carries an initial called number, and sending a message of the called number with a same number service characteristic to first switching equipment in an IP network when the initial called number is a number of the same number service; and receiving a call request initiated by the first switching equipment, starting same number service processing of the initial called number according to the message carried in the call request, and calling a same number terminal corresponding to the initial called number. The embodiment of the invention helps realize the same number service between a SIP intelligent terminal in the IP network and ordinary terminals in other communication networks.
摘要翻译： 公开了一种呼叫处理方法，呼叫处理系统和同一号码业务的呼叫处理设备。 该方法包括：接收由主叫客户端发起并携带初始被叫号码的呼叫，并且当初始被叫号码为1时，向IP网络中的第一交换设备发送具有相同号码业务特性的被叫号码的消息 同一号码服务号码; 以及接收由所述第一交换设备发起的呼叫请求，根据所述呼叫请求中携带的消息，开始对所述初始被叫号码的相同号码业务处理，并且呼叫与所述初始被叫号码对应的同一号码终端。 本发明的实施例有助于实现IP网络中的SIP智能终端与其他通信网络中的普通终端之间的相同号码业务。
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