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1.发明授权Thiazole derivatives as SGLT2 inhibitors and pharmaceutical composition comprising same 有权作为SGLT2抑制剂的噻唑衍生物和包含其的药物组合物公开(公告)号：US08586550B2
公开(公告)日：2013-11-19
申请号：US13704081
申请日：2011-06-10
申请人： Jinhwa Lee , Jeongmin Kim , Suk Ho Lee , Junwon Lee , Kwang-Seop Song , Eun-Jung Park , Min Ju Kim , Hee Jeong Seo , Sung-Han Lee , Eun Jung Son , Jong Yup Kim , Suk Youn Kang , Younggyu Kong
发明人： Jinhwa Lee , Jeongmin Kim , Suk Ho Lee , Junwon Lee , Kwang-Seop Song , Eun-Jung Park , Min Ju Kim , Hee Jeong Seo , Sung-Han Lee , Eun Jung Son , Jong Yup Kim , Suk Youn Kang , Younggyu Kong
IPC分类号： A61K31/70 , A61K31/425 , C07H5/04 , C07H5/06 , C07D277/60
CPC分类号： C07H7/04 , C07D309/10 , C07D417/10 , C07D417/14 , C07D493/10 , C07H17/02
摘要： The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.
摘要翻译： 本发明涉及一种具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的噻唑环的新型化合物，以及包含其作为活性成分的药物组合物，其可用于预防 或治疗代谢紊乱，特别是糖尿病。
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2.发明申请Thiazole Derivatives as SGLT2 Inhibitors and Pharmaceutical Composition Comprising Same 有权噻唑衍生物作为SGLT2抑制剂和药物组合物组成公开(公告)号：US20130090298A1
公开(公告)日：2013-04-11
申请号：US13704081
申请日：2011-06-10
申请人： Jinhwa Lee , Jeongmin Kim , Suk Ho Lee , Junwon Lee , Kwang-Seop Song , Eun-Jung Park , Min Ju Kim , Hee Jeong Seo , Sung-Han Lee , Eun Jung Son , Jong Yup Kim , Suk Youn Kang , Younggyu Kong
发明人： Jinhwa Lee , Jeongmin Kim , Suk Ho Lee , Junwon Lee , Kwang-Seop Song , Eun-Jung Park , Min Ju Kim , Hee Jeong Seo , Sung-Han Lee , Eun Jung Son , Jong Yup Kim , Suk Youn Kang , Younggyu Kong
CPC分类号： C07H7/04 , C07D309/10 , C07D417/10 , C07D417/14 , C07D493/10 , C07H17/02
摘要： The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.
摘要翻译： 本发明涉及一种具有对存在于肠和肾中的钠依赖性葡萄糖协同转运蛋白2（SGLT2）具有抑制活性的噻唑环的新型化合物，以及包含其作为活性成分的药物组合物，其可用于预防 或治疗代谢紊乱，特别是糖尿病。
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3.发明授权C-aryl glucoside SGLT2 inhibitors and pharmaceutical compositions comprising same 有权C-芳基葡糖苷SGLT2抑制剂和包含其的药物组合物公开(公告)号：US08541380B2
公开(公告)日：2013-09-24
申请号：US13379301
申请日：2010-06-18
申请人： Jinhwa Lee , Suk Ho Lee , Hee Jeong Seo , Min Ju Kim , Suk Youn Kang , Jeongmin Kim , Sung-Han Lee , Myung Eun Jung , Eun Jung Son , Kwang-Seop Song , Mi-Soon Kim
发明人： Jinhwa Lee , Suk Ho Lee , Hee Jeong Seo , Min Ju Kim , Suk Youn Kang , Jeongmin Kim , Sung-Han Lee , Myung Eun Jung , Eun Jung Son , Kwang-Seop Song , Mi-Soon Kim
CPC分类号： C07D417/14 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10
摘要： A novel C-aryl glucoside compound, or a pharmaceutically acceptable salt or a prodrug thereof having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney; and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly, diabetes, are provided.
摘要翻译： 在肠和肾中存在对钠依赖性葡萄糖共转运体2（SGLT2）具有抑制活性的新型C-芳基葡糖苷化合物或其药学上可接受的盐或前药; 并且提供了包含其作为活性成分的药物组合物，其可用于预防或治疗代谢紊乱，特别是糖尿病。
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4.发明申请NOVEL C-ARYL GLUCOSIDE SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 有权新型C-ARYL GLUCOSIDE SGLT2抑制剂和包含其的药物组合物公开(公告)号：US20120101051A1
公开(公告)日：2012-04-26
申请号：US13379301
申请日：2010-06-18
申请人： Jinhwa Lee , Suk Ho Lee , Hee Jeong Seo , Min Ju Kim , Suk Youn Kang , Jeongmin Kim , Sung-Han Lee , Myung Eun Jung , Eun Jung Son , Kwang-Seop Song , Mi-Soon Kim
发明人： Jinhwa Lee , Suk Ho Lee , Hee Jeong Seo , Min Ju Kim , Suk Youn Kang , Jeongmin Kim , Sung-Han Lee , Myung Eun Jung , Eun Jung Son , Kwang-Seop Song , Mi-Soon Kim
IPC分类号： A61K31/706 , A61P3/10 , A61P3/00 , C08B37/00 , A61K31/7056
CPC分类号： C07D417/14 , C07D405/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/10
摘要： A novel C-aryl glucoside compound, or a pharmaceutically acceptable salt or a prodrug thereof having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney; and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly, diabetes, are provided.
摘要翻译： 在肠和肾中存在对钠依赖性葡萄糖共转运体2（SGLT2）具有抑制活性的新型C-芳基葡糖苷化合物或其药学上可接受的盐或前药; 并且提供了包含其作为活性成分的药物组合物，其可用于预防或治疗代谢紊乱，特别是糖尿病。
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公开(公告)号：US20080262066A1
公开(公告)日：2008-10-23
申请号：US12105460
申请日：2008-04-18
申请人： Jinhwa LEE , Jeongmin Kim , Kwang-Seop Song , Min Ah Kim , Jong Yup Kim , Suk Ho Lee , Hee Jeong Seo , Sung-Han Lee , Myung Eun Jung , Kwang Woo Ahn , Eun Jung Son
发明人： Jinhwa LEE , Jeongmin Kim , Kwang-Seop Song , Min Ah Kim , Jong Yup Kim , Suk Ho Lee , Hee Jeong Seo , Sung-Han Lee , Myung Eun Jung , Kwang Woo Ahn , Eun Jung Son
IPC分类号： A61K31/415 , C07D231/14 , A61K31/4164 , A61P3/00 , C07D233/54
CPC分类号： C07D231/14 , C07D233/90
摘要： A novel azole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The prevention also provides a method for preparing same, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.
摘要翻译： 式（I）的新型唑化合物或其药学上可接受的盐作为大麻素CB 1受体反向激动剂或拮抗剂是有效的，其可用于预防或治疗肥胖症和与肥胖有关的代谢紊乱。 预防还提供其制备方法，含有其的药物组合物，以及预防或治疗肥胖症和肥胖相关的代谢紊乱的方法。
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6.发明申请ORALLY BIOAVAILABLE PRODUCTS OF (+)-3-HYDROXYMORPHINAN FOR PARKINSON'S DISEASE PREVENTION OR TREATMENT 失效（+） - 3-羟基吗啡酮用于帕金森病防治或治疗的ORALLY BIOAVAILABLE产品公开(公告)号：US20100113500A1
公开(公告)日：2010-05-06
申请号：US12530444
申请日：2008-03-07
申请人： Jinhwa Lee , Jeongmin Kim , Myung Eun Jung , Jong Yup Kim , Kwang-Seop Song , Eun Jung Son , Suk Ho Lee , Ho Kyun Han , Min Ju Kim , MinWoo Lee
发明人： Jinhwa Lee , Jeongmin Kim , Myung Eun Jung , Jong Yup Kim , Kwang-Seop Song , Eun Jung Son , Suk Ho Lee , Ho Kyun Han , Min Ju Kim , MinWoo Lee
IPC分类号： A61K31/4748 , C07D221/28 , A61P25/16
CPC分类号： C07D221/28
摘要： The present invention is directed to a novel prodrug of (+)-3-hydroxymorphinan compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the same, and its use for preventing or treating Parkinson's disease.
摘要翻译： 本发明涉及式（I）的（+） - 3-羟基吗啡喃化合物或其药学上可接受的盐，其制备方法及其用于预防或治疗帕金森病的新型前药。
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7.发明授权Orally bioavailable prodrugs of (+)-3-hydroxymorphinan for Parkinson'S disease prevention or treatment 失效（+） - 3-羟基吗啡喃的口服生物可利用前药用于帕金森病的预防或治疗公开(公告)号：US08178551B2
公开(公告)日：2012-05-15
申请号：US12530444
申请日：2008-03-07
申请人： Jinhwa Lee , Jeongmin Kim , Myung Eun Jung , Jong Yup Kim , Kwang-Seop Song , Eun Jung Son , Suk Ho Lee , Ho Kyun Han , Min Ju Kim , MinWoo Lee
发明人： Jinhwa Lee , Jeongmin Kim , Myung Eun Jung , Jong Yup Kim , Kwang-Seop Song , Eun Jung Son , Suk Ho Lee , Ho Kyun Han , Min Ju Kim , MinWoo Lee
IPC分类号： A61K31/439 , C07D221/28
CPC分类号： C07D221/28
摘要： The present invention is directed to a novel prodrug of (+)-3-hydroxymorphinan compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the same, and its use for preventing or treating Parkinson's disease.
摘要翻译： 本发明涉及式（I）的（+） - 3-羟基吗啡喃化合物或其药学上可接受的盐，其制备方法及其用于预防或治疗帕金森病的新型前药。
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8.发明申请COMPOSITION FOR TREATING ATOPIC DERMATITIS COMPRISING EXTRACTS OF BAMBOO AND SCUTELLARIA 有权用于处理包含BAMBOO和SCUTELLARIA的提取物的原生质体的组合物公开(公告)号：US20130064910A1
公开(公告)日：2013-03-14
申请号：US13586741
申请日：2012-08-15
申请人： Sung Sick Woo , Dong Seon Kim , Young Chul Lee , Eun Jung Son
发明人： Sung Sick Woo , Dong Seon Kim , Young Chul Lee , Eun Jung Son
IPC分类号： A61K36/539 , A61P37/08
CPC分类号： A61K36/899 , A61K36/539
摘要： The present invention relates to a composition comprising of plant extract as an active component, specifically, Bamboo extract and Scutellaria extract, for the treatment and prevention of atopic dermatitis.The present invention is a natural ingredient obtained from a plant. The present invention can control immune responses by inhibiting the release of histamine and leukotrien, and thus, has effect in the treatment or prevention of allergic diseases, inflammatory diseases and skin diseases, specifically atopic dermatitis.The present invention has been proven safe and beneficial effecting the treatment of atopic dermatitis through clinical trials, and thus, can be used for the treatment and prevention of atopic dermatitis.
摘要翻译： 本发明涉及包含作为活性成分的植物提取物，特别是竹提取物和黄芩提取物的组合物，用于治疗和预防特应性皮炎。 本发明是从植物获得的天然成分。 本发明可以通过抑制组胺和白三烯的释放来控制免疫应答，从而具有治疗或预防过敏性疾病，炎性疾病和皮肤病，特别是特应性皮炎的作用。 已经证明本发明通过临床试验安全有益地治疗特应性皮炎，因此可用于治疗和预防特应性皮炎。
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9.发明申请Composition For Treating Atopic Dermatitis Comprising Extracts Of Bamboo And Scutellaria 有权用于治疗特应性皮炎的组合物，包括竹和黄芩提取物公开(公告)号：US20100015257A1
公开(公告)日：2010-01-21
申请号：US12445159
申请日：2007-10-12
申请人： Sung Sick Woo , Dong Seon Kim , Young Chul Lee , Eun Jung Son
发明人： Sung Sick Woo , Dong Seon Kim , Young Chul Lee , Eun Jung Son
IPC分类号： A61K36/899 , A61P17/00
CPC分类号： A61K36/899 , A61K36/539
摘要： The present invention relates to a composition comprising of plant extract as an active component, specifically, Bamboo extract and Scutellaria extract, for the treatment and prevention of atopic dermatitis. The present invention is a natural ingredient obtained from a plant. The present invention can control immune responses by inhibiting the release of histamine and leukotrien, and thus, has effect in the treatment or prevention of allergic diseases, inflammatory diseases and skin diseases, specifically atopic dermatitis. The present invention has been proven safe and beneficial effecting the treatement of atopic dermitatis through clinical trials, and thus, can be used for the treatment and prevention of atopic dermitatis.
摘要翻译： 本发明涉及包含作为活性成分的植物提取物，特别是竹提取物和黄芩提取物的组合物，用于治疗和预防特应性皮炎。 本发明是从植物获得的天然成分。 本发明可以通过抑制组胺和白三烯的释放来控制免疫应答，从而具有治疗或预防过敏性疾病，炎性疾病和皮肤病，特别是特应性皮炎的作用。 通过临床试验已经证明本发明是安全和有益的，从而影响特应性皮肤病的治疗，因此可用于治疗和预防特应性皮肤病。
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10.发明授权Composition for treating atopic dermatitis comprising extracts of bamboo and scutellaria 有权用于治疗特应性皮炎的组合物，其包含竹和黄芩提取物公开(公告)号：US08771761B2
公开(公告)日：2014-07-08
申请号：US13586741
申请日：2012-08-15
申请人： Sung Sick Woo , Dong Seon Kim , Young Chul Lee , Eun Jung Son
发明人： Sung Sick Woo , Dong Seon Kim , Young Chul Lee , Eun Jung Son
IPC分类号： A61K36/00 , A61K36/539 , A61K36/899
CPC分类号： A61K36/899 , A61K36/539
摘要： The present invention relates to a composition comprising of plant extract as an active component, specifically, Bamboo extract and Scutellaria extract, for the treatment and prevention of atopic dermatitis. The present invention is a natural ingredient obtained from a plant. The present invention can control immune responses by inhibiting the release of histamine and leukotriene, and thus, has effect in the treatment or prevention of allergic diseases, inflammatory diseases and skin diseases, specifically atopic dermatitis. The present invention has been proven safe and beneficial effecting the treatment of atopic dermatitis through clinical trials, and thus, can be used for the treatment and prevention of atopic dermatitis.
摘要翻译： 本发明涉及包含作为活性成分的植物提取物，特别是竹提取物和黄芩提取物的组合物，用于治疗和预防特应性皮炎。 本发明是从植物获得的天然成分。 本发明可以通过抑制组胺和白三烯的释放来控制免疫应答，从而具有治疗或预防过敏性疾病，炎性疾病和皮肤病，特别是特应性皮炎的作用。 已经证明本发明通过临床试验安全有益地治疗特应性皮炎，因此可用于治疗和预防特应性皮炎。
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