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公开(公告)号：US08440147B2
公开(公告)日：2013-05-14
申请号：US13143070
申请日：2009-12-30
CPC分类号： B01L3/50273 , B01L2300/0803 , B01L2300/0861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688
摘要： Devices for generating discrete flow of liquids in response to a driving force, for example centrifugal microfluidic devices for generating discrete flow in response to a constant driving force. The device includes a supply structure for supplying liquid at an inflow rate to a discretization structure in response to a driving force. The discretization structure is shaped to define an outlet and a level to which the discretization structure fills with liquid flowing from the supply structure before dispensing the liquid at an outflow rate through the outlet in response to the driving force. The device is arranged such that the outflow rate from the discretization structure is greater than the inflow rate into the discretization structure, thereby periodically emptying the discretization structure to create a discretized flow from the outlet. The devices find applications in liquid mixing, for example for diluting samples, such as blood plasma samples.
摘要翻译： 用于响应于驱动力产生离散流体的装置，例如用于响应于恒定驱动力产生离散流的离心微流体装置。 该装置包括用于响应于驱动力以流入速率向离散结构供应液体的供应结构。 离散化结构被成形为在响应于驱动力通过出口以分流液体分配液体之前，界定离散化结构填充有从供给结构流出的液体的出口和水平。 该装置被布置成使得离离离结构的流出速率大于进入离散化结构的流入速率，从而周期性地排空离散化结构以从出口产生离散的流。 这些装置可用于液体混合，例如稀释样品，如血浆样品。
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公开(公告)号：US20130074962A1
公开(公告)日：2013-03-28
申请号：US13638378
申请日：2011-03-26
IPC分类号： F17D1/08
CPC分类号： F17D1/08 , B01L3/50273 , B01L2200/0605 , B01L2200/0621 , B01L2200/0642 , B01L2300/048 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , Y10T137/87249 , Y10T436/2575
摘要： Devices for handling liquid, for example microfluidic devices, are described, which are rotatable about an axis of rotation to drive liquid flow within the device. The 5 devices provide one or more of an aliquoting structure (6) having a plurality of daisy chained aliquoting chambers (100, 200, 300) for providing a plurality of aliquots, arrangements for sequencing the dispensing of the aliquots by controlling the rotation of the device and arrangements for ensuring that a fault condition can be detected when insufficient liquid is present in the device to fill 10 all aliquots. Further disclosed are arrangements for ensuring a detection chamber (12) of the device remains filled with liquid, arrangements for reducing the risk of air ingress to the detection chamber (12) on repeated emptying and filling of a supply structure (10) and arrangements for reducing the risk of bubble formation when filling the detection chamber (12). A corresponding system for operating the 15 device and method for processing of a sample using the device is also disclosed.
摘要翻译： 描述了用于处理液体的装置，例如微流体装置，其可围绕旋转轴线旋转以驱动装置内的液体流。 5装置提供一个或多个等分装置结构（6），其具有多个用于提供多个等分试样的菊花链等分装置（100,200,300），用于通过控制所述等分试样的旋转来排序等分试样的排列 装置和布置，用于确保在装置中存在不足的液体以便填满10个所有等分试样时可以检测到故障状况。 还公开了用于确保设备的检测室（12）保持充满液体的布置，用于在反复排空和填充供应结构（10）时降低空气进入检测室（12）的风险的布置和布置 当填充检测室（12）时，降低气泡形成的风险。 还公开了一种用于操作该装置的方法和用于使用该装置处理样品的方法的相应系统。
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公开(公告)号：US20120021447A1
公开(公告)日：2012-01-26
申请号：US13143070
申请日：2009-12-30
IPC分类号： C12Q1/37
CPC分类号： B01L3/50273 , B01L2300/0803 , B01L2300/0861 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688
摘要： Devices for generating discrete flow of liquids in response to a driving force, for example centrifugal microfluidic devices for generating discrete flow in response to a constant driving force. The device includes a supply structure for supplying liquid at an inflow rate to a discretization structure in response to a driving force. The discretization structure is shaped to define an outlet and a level to which the discretization structure fills with liquid flowing from the supply structure before dispensing the liquid at an outflow rate through the outlet in response to the driving force. The device is arranged such that the outflow rate from the discretization structure is greater than the inflow rate into the discretization structure, thereby periodically emptying the discretization structure to create a discretized flow from the outlet. The devices find applications in liquid mixing, for example for diluting samples, such as blood plasma samples.
摘要翻译： 用于响应于驱动力产生离散流体的装置，例如用于响应于恒定驱动力产生离散流的离心微流体装置。 该装置包括用于响应于驱动力以流入速率向离散结构供应液体的供应结构。 离散化结构被成形为在响应于驱动力通过出口以分流液体分配液体之前，界定离散化结构填充有从供给结构流出的液体的出口和水平。 该装置被布置成使得离离离结构的流出速率大于进入离散化结构的流入速率，从而周期性地排空离散化结构以从出口产生离散的流。 这些装置可用于液体混合，例如稀释样品，如血浆样品。
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公开(公告)号：US08916112B2
公开(公告)日：2014-12-23
申请号：US13638378
申请日：2011-03-26
CPC分类号： F17D1/08 , B01L3/50273 , B01L2200/0605 , B01L2200/0621 , B01L2200/0642 , B01L2300/048 , B01L2300/0806 , B01L2300/0864 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , Y10T137/87249 , Y10T436/2575
摘要： Devices for handling liquid, for example microfluidic devices, are described, which are rotatable about an axis of rotation to drive liquid flow within the device. The 5 devices provide one or more of an aliquoting structure (6) having a plurality of daisy chained aliquoting chambers (100, 200, 300) for providing a plurality of aliquots, arrangements for sequencing the dispensing of the aliquots by controlling the rotation of the device and arrangements for ensuring that a fault condition can be detected when insufficient liquid is present in the device to fill 10 all aliquots. Further disclosed are arrangements for ensuring a detection chamber (12) of the device remains filled with liquid, arrangements for reducing the risk of air ingress to the detection chamber (12) on repeated emptying and filling of a supply structure (10) and arrangements for reducing the risk of bubble formation when filling the detection chamber (12). A corresponding system for operating the 15 device and method for processing of a sample using the device is also disclosed.
摘要翻译： 描述了用于处理液体的装置，例如微流体装置，其可围绕旋转轴线旋转以驱动装置内的液体流。 5装置提供一个或多个等分装置结构（6），其具有多个用于提供多个等分试样的菊花链等分装置（100,200,300），用于通过控制所述等分试样的旋转来排序等分试样的排列 装置和布置，用于确保在装置中存在不足的液体以便填满10个所有等分试样时可以检测到故障状况。 还公开了用于确保设备的检测室（12）保持充满液体的布置，用于在反复排空和填充供应结构（10）时降低空气进入检测室（12）的风险的布置和布置 当填充检测室（12）时，降低气泡形成的风险。 还公开了一种用于操作该装置的方法和用于使用该装置处理样品的方法的相应系统。
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