公开(公告)号：US07334405B2

公开(公告)日：2008-02-26

申请号：US11474917

申请日：2006-06-21

申请人： Joachim Augstein ,  Marcus Reissing ,  Roland Weik

发明人： Joachim Augstein ,  Marcus Reissing ,  Roland Weik

IPC分类号： F02B33/44 ,  F02B37/00 ,  F02B37/12 ,  F02D23/00

CPC分类号： F02D41/0007 ,  F02B37/18 ,  F02B39/16 ,  F02D2041/1409 ,  F02D2041/1422 ,  Y02T10/144

摘要： In a method of controlling an exhaust gas turbocharger of an internal combustion engine charged by a compressor wherein as guide value for the control an operating point of the compressor is used, the operation of each cylinder bank of the internal combustion engine is controlled by dividing the total air mass flow by the number of cylinder banks and an equal amount of desired air mass flow is assigned to each cylinder bank and if the air mass flow to any of the cylinder banks is smaller than that to the other or others air from the other cylinder bank or banks is supplied to the one cylinder bank via a compensation arrangement so that the air mass flows to all cylinder banks are essentially equal.

摘要翻译： 在控制由压缩机充气的内燃机的排气涡轮增压器的控制方法中，作为使用压缩机的运转点的控制的引导值，通过将内燃机的各气缸组的动作除以 气缸组的总空气质量流量和等量的期望空气质量流量被分配给每个气缸组，并且如果到任何气缸组的空气质量流量小于来自另一气缸组的空气质量流量 气缸组或组通过补偿装置供应到一个气缸组，使得流到所有气缸组的空气质量基本相等。

公开(公告)号：US20060271267A1

公开(公告)日：2006-11-30

申请号：US11474917

申请日：2006-06-21

申请人： Joachim Augstein ,  Marcus Reissing ,  Roland Weik

发明人： Joachim Augstein ,  Marcus Reissing ,  Roland Weik

IPC分类号： G06F17/00 ,  F02D23/00

CPC分类号： F02D41/0007 ,  F02B37/18 ,  F02B39/16 ,  F02D2041/1409 ,  F02D2041/1422 ,  Y02T10/144

摘要： In a method of controlling an exhaust gas turbocharger of an internal combustion engine charged by a compressor wherein as guide value for the control an operating point of the compressor is used, the operation of each cylinder bank of the internal combustion engine is controlled by dividing the total air mass flow by the number of cylinder banks and the same amount of desired air mass flow is assigned to each cylinder bank and if the air mass flow to any of the cylinder banks is smaller than that to the other or others air from the other cylinder bank or banks is supplied to the one cylinder bank via a compensation arrangement so that the air mass flow to all cylinder banks is essentially the same.

摘要翻译： 在控制由压缩机充气的内燃机的排气涡轮增压器的控制方法中，作为使用压缩机的运转点的控制的引导值，通过将内燃机的各气缸组的动作除以 总气体质量流量由气缸组数量和相同量的所需空气质量流量指定给每个气缸组，并且如果空气质量流向任何气缸组的空气质量流量小于其他空气质量流量 气缸组或组通过补偿装置供应到一个气缸组，使得到所有汽缸组的空气质量流量基本相同。

公开(公告)号：US20070283938A1

公开(公告)日：2007-12-13

申请号：US11801413

申请日：2007-05-09

申请人： Joachim Augstein ,  Frank Hangs ,  Arkadi Kudashev ,  Christian Pies

发明人： Joachim Augstein ,  Frank Hangs ,  Arkadi Kudashev ,  Christian Pies

IPC分类号： F02B37/04

CPC分类号： F01N13/18 ,  F01N13/10 ,  F01N13/107 ,  F02B37/007 ,  F02B37/02 ,  Y02T10/144

摘要： In a supercharged internal combustion engine having a plurality of cylinders which are arranged in at least one cylinder bank, preferably a V-type engine with an exhaust gas turbocharger including a compressor, which is arranged in an intake line of the internal combustion engine and a turbine which is arranged in an exhaust gas collection line, the exhaust gas of a plurality of cylinders of the cylinder bank is combined in an exhaust gas collection line, while at least one cylinder of a cylinder bank has a separate exhaust gas line which bypasses the exhaust gas turbocharger and joins the exhaust gas line downstream of the turbine.

摘要翻译： 在具有设置在至少一个气缸组中的多个气缸的增压内燃机中，优选具有排气涡轮增压器的V型发动机，所述排气涡轮增压器包括内燃机的进气管线和 设置在废气收集管路中的涡轮机，将气缸组的多个气缸的废气组合在废气收集管路中，而气缸组的至少一个气缸具有分开的排气管线， 废气涡轮增压器，并连接在涡轮下游的排气管线。

公开(公告)号：US4064256A

公开(公告)日：1977-12-20

申请号：US539437

申请日：1975-01-03

申请人： Joachim Augstein ,  Hugh Cairns ,  Dennis Hunter ,  John King

发明人： Joachim Augstein ,  Hugh Cairns ,  Dennis Hunter ,  John King

IPC分类号： A61K31/41 ,  C07D311/24 ,  C07D335/06 ,  C07F1/00

CPC分类号： C07D335/06 ,  C07C321/00 ,  C07C323/00 ,  C07D311/24 ,  C07F1/005 ,  Y10S514/826

摘要： There are described compounds of formula I, ##STR1## in which R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, are hydrogen, alkyl C2 to 6, alkoxy C2 to 8, hydroxy-alkoxy C3 to 8, and R.sub.5 may be hydroxy, provided that one or two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are other than hydrogen, and pharmaceutically acceptable derivatives thereof. The compounds of formula I are indicated for use in the treatment of asthma, and pharmaceutical compositions containing them and processes for their preparation are also described.

摘要翻译： 描述了式I的化合物，其中R 5，R 6，R 7和R 8可以相同或不同，为氢，烷基C2至6，烷氧基C2至8，羟基 - 烷氧基C3至8， 并且R 5可以是羟基，条件是R 5，R 6，R 7和R 8中的一个或两个不是氢，及其药学上可接受的衍生物。 式I化合物用于治疗哮喘，还描述了含有它们的药物组合物及其制备方法。

公开(公告)号：US4804678A

公开(公告)日：1989-02-14

申请号：US105508

申请日：1987-10-05

申请人： Joachim Augstein ,  Maqbool Ahmed

发明人： Joachim Augstein ,  Maqbool Ahmed

IPC分类号： A61K9/127 ,  A61K31/35

CPC分类号： A61K31/35 ,  A61K9/127 ,  Y10S514/826

摘要： There is described a pharmaceutical composition comprising liposomes and sodium cromoglycate.There is also described an aqueous suspension comprising sodium cromoglycate partitioned between a free aqueous phase and a liposome phase.There is further described a method for making the compositions, and their use in the treatment of allergic conditions, e.g., asthma.

摘要翻译： 描述了包含脂质体和色甘酸钠的药物组合物。 还描述了包含在游离水相和脂质体相之间分配的色甘酸钠的水性悬浮液。 进一步描述了制备组合物的方法及其用于治疗过敏性疾病例如哮喘的用途。

公开(公告)号：US4085115A

公开(公告)日：1978-04-18

申请号：US674732

申请日：1976-04-06

申请人： Joachim Augstein ,  Hugh Cairns ,  Norman Harold Rogers

发明人： Joachim Augstein ,  Hugh Cairns ,  Norman Harold Rogers

IPC分类号： C07D493/04 ,  C07D257/04 ,  A61K31/41

CPC分类号： C07D493/04

摘要： There are described compounds of formula Ix, ##STR1## IN WHICH ONE OR MORE ADJACENT PAIRS OF P, Q, R and T represent a chain of formula XX, ##STR2## or a group of formula X, ##STR3## in which Ba and Bb represent the pair of groups:- a carbon-carbon bond and --CRa.dbd.CRb--; or an adjacent pair of P, Q, R and T represent a group of formula XI, ##STR4## Ra and Rb and those of P, Q, R and T which do not form a chain of formula XX or a group of formula X or XI may be the same or different and each represents hydrogen; alkyl; alkoxy; alkenyl; alkenyloxy; alkyl or alkoxy, substituted by a hydroxy, alkoxy, aryl or halo group; amino; mono- or di-lower alkylamino; aminoalkoxy; aminoalkoxy substituted by a lower alkyl group; nitro; hydroxy; halogen; acyl; or aryloxy.There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.

摘要翻译： 描述了式Ix的化合物，其中P，Q，R和T的一个或多个相邻对表示式XX的链， XX或一组式X， X在 其中Ba和Bb代表一对基团： - 碳 - 碳键和-CRa = CRb-; 或相邻的一对P，Q，R和T表示式XI，XIAa和Rb的基团，以及不形成式XX链或式 X或XI可以相同或不同，各自表示氢; 烷基; 烷氧基 烯基; 链烯氧基 被羟基，烷氧基，芳基或卤代基取代的烷基或烷氧基; 氨基; 单 - 或二 - 低级烷基氨基; 氨基烷氧基 被低级烷基取代的氨基烷氧基; 硝基 羟基; 卤素; 酰基; 或芳氧基。

公开(公告)号：US4006245A

公开(公告)日：1977-02-01

申请号：US545309

申请日：1975-01-29

申请人： Joachim Augstein ,  David Carter ,  Thomas Brian Lee

发明人： Joachim Augstein ,  David Carter ,  Thomas Brian Lee

IPC分类号： A61K31/35

摘要： There are provided compounds of formula I, ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7 may be the same or different, and are hydrogen, hydroxy, alkoxy, alkoxy substituted by phenyl, acyl, amino, acylamino, alkenyl, halogen, or alkyl, provided that at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.7 are other than hydrogen and hydroxy,Or an adjacent pair of R.sup.1, R.sup.2, R.sup.3 and R.sup.7 represent a chain --COCH=CH--O--,X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group, andE is a carboxy group or a tetrazole group,And pharmaceutically acceptable derivatives thereof.The compounds are indicated for use as antagonists of SRS-A.

摘要翻译： 提供式I化合物，其中R 1，R 2，R 3，R 4，R 5和R 7可以相同或不同，并且是氢，羟基，烷氧基，被苯基，酰基，氨基，酰氨基取代的烷氧基， 烯基，卤素或烷基，条件是R 1，R 2，R 3和R 7中的至少一个不同于氢和羟基，或者R 1，R 2，R 3和R 7的相邻对表示链-COCH = CH-O-， X是含有2至10个碳原子并且任选被羟基取代的烃链，E是羧基或四唑基，以及其药学上可接受的衍生物。

公开(公告)号：US4917897A

公开(公告)日：1990-04-17

申请号：US308196

申请日：1989-02-08

申请人： Joachim Augstein ,  Maqbool Ahmed

发明人： Joachim Augstein ,  Maqbool Ahmed

IPC分类号： A61K9/127 ,  A61K31/35

CPC分类号： A61K9/127 ,  A61K31/35 ,  Y10T428/2984

摘要： There is described a pharmaceutical composition comprising liposomes and sodium cromoglycate. There is also described an aqueous suspension comprising sodium cromoglycate partitioned between a free aqueous phase and a liposome phase. There is further described a method for making the compositions and their use in the treatment of allergic conditions, e.g., asthma.

摘要翻译： 描述了包含脂质体和色甘酸钠的药物组合物。 还描述了包含在游离水相和脂质体相之间分配的色甘酸钠的水性悬浮液。 进一步描述了用于制备组合物及其用于治疗过敏性疾病例如哮喘的方法。

公开(公告)号：US4133889A

公开(公告)日：1979-01-09

申请号：US725126

申请日：1976-09-20

申请人： Joachim Augstein ,  David Carter ,  Thomas B. Lee

发明人： Joachim Augstein ,  David Carter ,  Thomas B. Lee

IPC分类号： C07C45/71 ,  C07C51/09 ,  C07D303/22 ,  C07D303/26 ,  C07D311/24 ,  A61K31/41 ,  C07D207/44

CPC分类号： C07D303/22 ,  C07C45/71 ,  C07C51/09 ,  C07D303/26 ,  C07D311/24

摘要： There are provided compounds of formula I, ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7 may be the same or different, and are hydrogen, hydroxy, alkoxy, alkoxy substituted by phenyl, acyl, amino, acylamino, alkenyl, halogen, or alkyl, provided that at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.7 are other than hydrogen and hydroxy,Or an adjacent pair of R.sup.1, R.sup.2, R.sup.3 and R.sup.7 represent a chain --COCH.dbd.CH--O--,X is a hydrocarbon chain containing from 2 to 10 carbon atoms and optionally substituted by a hydroxy group, andE is a carboxy group or a 5-tetrazolyl group, and pharmaceutically acceptable derivatives thereof.The compounds are indicated for use as antagonists of SRS-A.

摘要翻译： 提供式I化合物，其中R 1，R 2，R 3，R 4，R 5和R 7可以相同或不同，并且是氢，羟基，烷氧基，被苯基，酰基，氨基，酰氨基取代的烷氧基， 烯基，卤素或烷基，条件是R 1，R 2，R 3和R 7中的至少一个不同于氢和羟基，或者R 1，R 2，R 3和R 7的相邻对表示链-COCH = CH-O-， X是含有2至10个碳原子并且任选被羟基取代的烃链，E是羧基或5-四唑基，以及其药学上可接受的衍生物。

公开(公告)号：US3933845A

公开(公告)日：1976-01-20

申请号：US175392

申请日：1971-08-26

申请人： Joachim Augstein ,  Hugh Cairns ,  Dennis Hunter ,  John King

发明人： Joachim Augstein ,  Hugh Cairns ,  Dennis Hunter ,  John King

IPC分类号： C07D311/22 ,  C07D311/24 ,  C07D335/06 ,  C07D405/04 ,  C07D409/04 ,  C07F1/00 ,  C07D405/14 ,  C07D413/14

CPC分类号： C07D335/06 ,  C07C321/00 ,  C07C323/00 ,  C07D311/24 ,  C07F1/005 ,  Y10S514/826

摘要： There are described compounds of formula I, ##SPC1##in which R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, are hydrogen, alkyl C2 to 6, alkoxy C2 to 8, hydroxy-alkoxy C3 to 8, and R.sub.5 may be hydroxy, provided that one or two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are other than hydrogen,And pharmaceutically acceptable derivatives thereof. The compounds of formula I are indicated for use in the treatment of asthma, and pharmaceutical compositions containing them and processes for their preparation are also described.

摘要翻译： 描述了式I的化合物，其中可以相同或不同的R 5，R 6，R 7和R 8是氢，C 2-6烷基，烷氧基C 2至8，羟基 - 烷氧基C 3至8和R 5可以是 羟基，条件是R 5，R 6，R 7和R 8中的一个或两个不是氢，并且其药学上可接受的衍生物。 式I化合物用于治疗哮喘，还描述了含有它们的药物组合物及其制备方法。