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    Use of sFRPs as markers of BMP activity
    1.
    发明申请
    Use of sFRPs as markers of BMP activity 审中-公开
    使用sFRPs作为BMP活性的标记

    公开(公告)号：US20060166251A1

    公开(公告)日：2006-07-27

    申请号：US11339549

    申请日：2006-01-26

    申请人： Joanne Archambault ,  Scott Jelinsky ,  Michael Agostino ,  Li Li ,  Howard Seeherman

    发明人： Joanne Archambault ,  Scott Jelinsky ,  Michael Agostino ,  Li Li ,  Howard Seeherman

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5023

    摘要： The disclosure provides assay systems for evaluating the presence of bone morphogenetic protein (BMP) activity in a cell by evaluating the gene expression of secreted Frizzled Related Protein 2 and 3 (sFRP2 and sFRP3). The sFRP2 and sFRP3 gene expression may be detected at the RNA or protein levels. The methods include methods for evaluating exogenous and endogenous BMP expression and utilize both genomic sFRP2 and sFRP3 genes and reporter constructs.

    摘要翻译： 本公开提供了通过评估分泌的卷曲相关蛋白2和3（sFRP2和sFRP3）的基因表达来评估细胞中骨形态发生蛋白（BMP）活性的存在的测定系统。 可以在RNA或蛋白质水平检测sFRP2和sFRP3基因表达。 该方法包括评估外源和内源性BMP表达的方法，并利用基因组sFRP2和sFRP3基因和报道构建体。

    Method and system for providing a flexible product purchase account for members of a healthcare organization
    2.
    发明授权
    Method and system for providing a flexible product purchase account for members of a healthcare organization 有权
    为医疗机构成员提供灵活的产品采购帐户的方法和系统

    公开(公告)号：US07566000B2

    公开(公告)日：2009-07-28

    申请号：US11060158

    申请日：2005-02-17

    申请人： Michael Agostino ,  Scott A. McArthur ,  Doug Egan

    发明人： Michael Agostino ,  Scott A. McArthur ,  Doug Egan

    IPC分类号： G06K7/10

    CPC分类号： G06Q30/02 ,  G06Q20/40

    摘要： A method and system for facilitating a redemption of benefits for a customer with the use of a benefit card is provided that includes associating an identification code with the customer, the identification code being stored on the benefit card, accessing an account record associated with the identification code, and determining if an item presented for purchase by the customer is eligible for a benefit discount. Also included is calculating an appropriate discount for the item if it is determined that the item was eligible for a benefit discount.

    摘要翻译： 提供一种方法和系统，用于促进使用利益卡为客户兑换利益，其包括将识别码与客户相关联，识别码存储在利益卡上，访问与识别相关联的帐户记录 代码，以及确定由客户呈现供购买的物品是否符合获利优惠。 还包括如果确定该项目有资格获得优惠折扣，则计算该项目的适当折扣。

    Light-weight floor-standing drain cleaner
    4.
    发明授权
    Light-weight floor-standing drain cleaner 失效
    轻便落地式排水清洁剂

    公开(公告)号：US4290162A

    公开(公告)日：1981-09-22

    申请号：US139985

    申请日：1980-04-14

    申请人： Michael Agostino

    发明人： Michael Agostino

    IPC分类号： E03F9/00 ,  B08B9/02

    CPC分类号： E03F9/005

    摘要： Employing a relatively short cable in a drum with a closely spaced inner portion, an effective floor-standing drain cleaner is provided which is portable, usable in most simple situations, is light in weight and drivable by a removable electric hand drill.

    摘要翻译： 在具有紧密间隔的内部部分的鼓中使用相对较短的电缆，提供有效的落地式排水清洁器，其是便携式的，可在大多数简单的情况下使用，重量轻并且可通过可拆卸的电动手钻驱动。

    Truncated ADAMTS molecules
    5.
    发明申请
    Truncated ADAMTS molecules 审中-公开
    截断的ADAMTS分子

    公开(公告)号：US20050277175A1

    公开(公告)日：2005-12-15

    申请号：US11109157

    申请日：2005-04-18

    申请人： Edward LaVallie ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Natalie Twine ,  Michael Agostino

    发明人： Edward LaVallie ,  Lisa Collins-Racie ,  Christopher Corcoran ,  Natalie Twine ,  Michael Agostino

    IPC分类号： C07H21/04 ,  C12N9/64 ,  C12P21/06

    CPC分类号： C12N9/6489

    摘要： The invention provides truncated biologically active ADAMTS polypeptides, particularly those with hyalectenase activity, and more particularly those with aggrecanase activity, that exhibit greater stability and homogeneity and higher expression yields than their full-length counterparts. The invention also provides nucleic acid molecules encoding such truncated biologically active ADAMTS polypeptides and methods for producing the truncated biologically active ADAMTS polypeptides. In addition, the invention provides methods for identifying compounds capable of modulating biologically active ADAMTS polypeptides, particularly those compounds that inhibit aggrecanase activity.

    摘要翻译： 本发明提供截短的生物活性ADAMTS多肽，特别是那些具有透明质酸酶活性的多肽，更具体地，具有聚集蛋白聚糖蛋白聚糖酶活性的多肽，其表现出比其全长对应物更大的稳定性和均一性和更高的表达产率。 本发明还提供编码这种截短的生物活性ADAMTS多肽的核酸分子和用于产生截短的生物活性ADAMTS多肽的方法。 此外，本发明提供了鉴定能够调节生物活性ADAMTS多肽，特别是那些抑制聚蛋白聚糖蛋白酶活性的化合物的化合物的方法。

    Buoyant and non-buoyant valve
    7.
    发明授权
    Buoyant and non-buoyant valve 失效
    浮力和非浮力阀

    公开(公告)号：US4841580A

    公开(公告)日：1989-06-27

    申请号：US132319

    申请日：1987-12-14

    申请人： Michael Agostino

    发明人： Michael Agostino

    IPC分类号： E03D1/14

    CPC分类号： E03D1/142

    摘要： A flush valve for use in a flush tank for control by the operator of the amount used in flushing, the valve including an elongate body having a solid generally hemispherical protuberance extending outwardly on one side and a hollow frusto-conical cup member extending outwardly from the other side. A tab and opening therethrough on the forward portion of the body for connection to the valve operating system allows the valve to be alternatively turned with the cup member facing upward and being non-buoyant or having the cup member facing downwardly whereby air trapped therein renders the valve buoyant for substantially a full flush. Spaced arm members extend laterally from the rearward portion of the valve body and have one or more openings pivotally mounting the valve to the normal overflow tube to position the valve with respect to the water outlet in either selected position.

    摘要翻译： 一种用于冲洗水箱的冲洗阀，用于操作者用于冲洗的量控制，该阀包括一个细长体，该细长体具有在一侧向外延伸的实心大致半球状的突起，以及从该侧向外延伸的中空的截头圆锥形杯构件 另一边。 在主体的前部与阀操作系统连接的突片和开口允许阀可选地转动，其中杯构件面向上并且是非浮力的或者使杯体面向下，从而使空气被捕获在其中 阀浮力基本上完全冲洗。 间隔的臂构件从阀体的后部横向延伸并且具有一个或多个开口可枢转地将阀安装到正常溢流管，以将阀相对于出水口定位在任一选定位置。

    Dual flush valve assembly
    8.
    发明授权
    Dual flush valve assembly 失效
    双冲程阀总成

    公开(公告)号：US4829605A

    公开(公告)日：1989-05-16

    申请号：US30369

    申请日：1987-03-26

    申请人： Michael Agostino

    发明人： Michael Agostino

    IPC分类号： E03D1/14

    CPC分类号： E03D1/142

    摘要： A dual flush valve assembly for a toilet tank including an overflow pipe, a pair of spaced inlets communicating with the pipe, a pair of flap valves selectively closing the inlets, a pair of spaced handles connected to respective valve operating rods controlling the flap valves, a fitting disposed in an opening in a front of a tank mounting the handles thereto in substantially the same vertical plane one above the other, and two spaced pairs of shoulders extending outwardly from the fitting with the handles being movable between a respective spaced pair of shoulders to limit the movement thereof. The flap valves have a wedge shaped body and are reversible for increased life thereof. The pipe and pair of inlets are removably mounted to a drain extending within the tank from the toilet basin without removal of the drain pipe. The overflow pipe may be aligned with the drain pipe with the inlets being offset therefrom, or one drain pipe and full flush inlet may be offset with the partial flush inlet being aligned with the drain pipe.

    摘要翻译： 一种用于马桶水箱的双冲洗阀组件，包括溢流管，与管连通的一对间隔开的入口，一对选择性地关闭入口的活门阀，连接到控制活瓣阀的相应阀操作杆的一对隔开的手柄， 一个配置在一个开口中，一个安装手柄的开口中的一个开口，该手柄在大体上相同的垂直平面上相互垂直放置，并且两个间隔开的一对肩部从配件向外伸出，手柄可在相应间隔开的肩部之间移动 以限制其运动。 瓣阀具有楔形体，并且是可逆的以增加其寿命。 管道和一对入口可移除地安装到从马桶盆内延伸到罐内的排水口，而不需排除排水管。 溢流管可以与排水管对准，其中入口从其排出，或者一个排水管和全冲洗入口可以偏移，而部分冲洗入口与排水管对齐。