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1.发明授权Anticoagulant antidotes comprising antibodies that bind dabigatran and/or related compounds and methods of use thereof 有权抗凝血剂解毒剂，其包含结合达比加群和/或相关化合物的抗体及其使用方法公开(公告)号：US08821871B2
公开(公告)日：2014-09-02
申请号：US13432296
申请日：2012-03-28
申请人： Joanne Van Ryn , Keith Canada , Robert Copenhaver , Norbert Hauel , Tobias Litzenburger , Christopher Ronald Sarko , Sanjaya Singh , Alisa K. Waterman
发明人： Joanne Van Ryn , Keith Canada , Robert Copenhaver , Norbert Hauel , Tobias Litzenburger , Christopher Ronald Sarko , Sanjaya Singh , Alisa K. Waterman
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/44 , A61K31/4439 , A61K39/395 , A61K39/39583 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
摘要翻译： 本发明涉及针对抗凝剂，特别是达比加群的抗体分子，以及它们作为这种抗凝剂的解毒剂的用途。
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2.发明授权Methods of using antibodies during anticoagulant therapy of dabigatran and/or related compounds 有权在达比加群和/或相关化合物的抗凝治疗期间使用抗体的方法公开(公告)号：US09034822B2
公开(公告)日：2015-05-19
申请号：US13916994
申请日：2013-06-13
申请人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
发明人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/44 , A61K31/4439 , A61K39/39583 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , G01N33/86 , G01N2500/02 , G01N2500/10
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
摘要翻译： 本发明涉及针对抗凝剂，特别是达比加群的抗体分子，以及它们作为这种抗凝剂的解毒剂的用途。
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3.发明授权Anticoagulant antidotes comprising antibodies that bind dabigatran and/or related compounds 有权抗凝血剂解毒剂，其包含结合达比加群和/或相关化合物的抗体公开(公告)号：US08486398B2
公开(公告)日：2013-07-16
申请号：US13010403
申请日：2011-01-20
申请人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
发明人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
IPC分类号： A61K39/395
CPC分类号： C07K16/44 , A61K31/4439 , A61K39/39583 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , G01N33/86 , G01N2500/02 , G01N2500/10
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
摘要翻译： 本发明涉及针对抗凝剂，特别是达比加群的抗体分子，以及它们作为这种抗凝剂的解毒剂的用途。
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公开(公告)号：US20120027780A1
公开(公告)日：2012-02-02
申请号：US13010403
申请日：2011-01-20
申请人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
发明人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
IPC分类号： A61K39/395 , A61P7/04 , C12P21/00 , C07K16/00
CPC分类号： C07K16/44 , A61K31/4439 , A61K39/39583 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , G01N33/86 , G01N2500/02 , G01N2500/10
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
摘要翻译： 本发明涉及针对抗凝剂的抗体分子，特别是达比加群，以及它们作为这种抗凝剂的解毒剂的用途。
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公开(公告)号：US08591900B2
公开(公告)日：2013-11-26
申请号：US13075303
申请日：2011-03-30
申请人： Rachel Rebecca Barrett , Scott Ronald Brodeur , Keith Canada , Tobias Litzenburger , Sanjaya Singh
发明人： Rachel Rebecca Barrett , Scott Ronald Brodeur , Keith Canada , Tobias Litzenburger , Sanjaya Singh
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , A61K9/0019 , A61K2039/505 , C07K1/22 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same.
摘要翻译： 本发明涉及新的人源化拮抗性抗CD40抗体及其使用的治疗和诊断方法及组合物。
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公开(公告)号：US09090696B2
公开(公告)日：2015-07-28
申请号：US14046121
申请日：2013-10-04
申请人： Rachel Rebecca Barrett , Scott Ronald Brodeur , Keith Canada , Tobias Litzenburger , Sanjaya Singh
发明人： Rachel Rebecca Barrett , Scott Ronald Brodeur , Keith Canada , Tobias Litzenburger , Sanjaya Singh
CPC分类号： C07K16/2878 , A61K9/0019 , A61K2039/505 , C07K1/22 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same.
摘要翻译： 本发明涉及新的人源化拮抗性抗CD40抗体及其使用的治疗和诊断方法及组合物。
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公开(公告)号：US09499633B2
公开(公告)日：2016-11-22
申请号：US14521499
申请日：2014-10-23
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/44 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
摘要翻译： 本发明涉及针对抗凝剂，特别是达比加群的抗体分子，以及它们作为这种抗凝剂的解毒剂的用途。
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公开(公告)号：US20130209449A9
公开(公告)日：2013-08-15
申请号：US13494398
申请日：2012-06-12
申请人： Stefan Bassarab , Barbara Enenkel , Patrick Garidel , Heidrun Schott , Sanjaya Singh , Tobias Litzenburger
发明人： Stefan Bassarab , Barbara Enenkel , Patrick Garidel , Heidrun Schott , Sanjaya Singh , Tobias Litzenburger
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/53
摘要： Provided herein, in one aspect, are antibodies that immunospecifically bind to PSGL-1, polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to PSGL-1, as well as methods of treating a disorder or disease caused by or associated with increased proliferation and/or numbers of activated T cells using the antibodies described herein.
摘要翻译： 本文提供的一方面是免疫特异性结合PSGL-1的抗体，包含编码这种抗体的核苷酸序列的多核苷酸，以及用于产生此类抗体的表达载体和宿主细胞。 本文还提供了包含特异性结合PSGL-1的抗体的试剂盒和药物组合物，以及使用本文所述的抗体治疗由增殖和/或激活的T细胞数量增加引起或与其相关的病症或疾病的方法。
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公开(公告)号：US20130011391A1
公开(公告)日：2013-01-10
申请号：US13494398
申请日：2012-06-12
申请人： Stefan Bassarab , Barbara Enenkel , Patrick Garidel , Heidrun Schott , Sanjaya Singh , Tobias Litzenburger
发明人： Stefan Bassarab , Barbara Enenkel , Patrick Garidel , Heidrun Schott , Sanjaya Singh , Tobias Litzenburger
CPC分类号： C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/53
摘要： Provided herein, in one aspect, are antibodies that immunospecifically bind to PSGL-1, polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. Also provided herein are kits and pharmaceutical compositions comprising antibodies that specifically bind to PSGL-1, as well as methods of treating a disorder or disease caused by or associated with increased proliferation and/or numbers of activated T cells using the antibodies described herein.
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公开(公告)号：US20120114659A1
公开(公告)日：2012-05-10
申请号：US13132493
申请日：2009-11-17
IPC分类号： A61K39/395 , C12N15/13 , A61P9/04 , A61P9/12 , A61P9/10 , A61P13/12 , A61P25/00 , A61P9/00 , A61P9/06 , A61P7/02 , A61P3/00 , A61P37/08 , A61P3/10 , A61P11/06 , A61P29/00 , A61P3/04 , A61P35/00 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12N1/15 , C12P21/00 , C12N9/96 , A61P7/10 , C07K16/40
CPC分类号： C07K16/2869 , C07K2317/24 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/75 , C07K2317/92 , C07K2319/30
摘要： Monoclonal antibodies that act as potentiators, stimulators and agonists of guanylyl cyclase receptors are disclosed.
摘要翻译： 公开了作为鸟苷酸环化酶受体的增强剂，刺激剂和激动剂的单克隆抗体。
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