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公开(公告)号:US20120095070A1
公开(公告)日:2012-04-19
申请号:US13263430
申请日:2010-04-29
申请人: Jochen Springer , Stefan Anker , Andrew Coats , John Beadle
发明人: Jochen Springer , Stefan Anker , Andrew Coats , John Beadle
IPC分类号: A61K31/404 , A61P21/00
CPC分类号: A61K31/404 , A61K31/00 , A61K31/133 , A61K31/138 , A61K31/382 , A61K31/4704 , A61K45/06
摘要: The present invention provides a means for prevention and treatment of sarcopenia by administration of a substance that both reduces the sensibility of beta-adrenergic receptors and of 5-HT1a receptors. (S)-pindolol, (S)-propanol, tertalol, or bopindolol are preferred for this purpose.
摘要翻译: 本发明提供了一种通过施用降低β-肾上腺素能受体和5-HT1a受体的敏感性的物质来预防和治疗肌肉减少症的手段。 (S) - 吲哚洛尔,(S) - 丙醇,叔醇或bopindolol是优选的。
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公开(公告)号:US08835485B2
公开(公告)日:2014-09-16
申请号:US13263430
申请日:2010-04-29
申请人: Jochen Springer , Stefan Anker , Andrew Coats , John Beadle
发明人: Jochen Springer , Stefan Anker , Andrew Coats , John Beadle
IPC分类号: A61K31/40 , A61K31/13 , A61K31/404 , A61K31/133
CPC分类号: A61K31/404 , A61K31/00 , A61K31/133 , A61K31/138 , A61K31/382 , A61K31/4704 , A61K45/06
摘要: The present invention provides a means for prevention and treatment of sarcopenia by administration of a substance that both reduces the sensibility of beta-adrenergic receptors and of 5-HT1a receptors. (S)-pindolol, (S)-propanol, tertalol, or bopindolol are preferred for this purpose.
摘要翻译: 本发明提供了一种通过施用降低β-肾上腺素能受体和5-HT1a受体的敏感性的物质来预防和治疗肌肉减少症的手段。 (S) - 吲哚洛尔,(S) - 丙醇,叔醇或bopindolol是优选的。
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公开(公告)号:US20140194484A1
公开(公告)日:2014-07-10
申请号:US14101272
申请日:2013-12-09
申请人: Andrew Coats , John Beadle , Stefan Anker
发明人: Andrew Coats , John Beadle , Stefan Anker
IPC分类号: A61K31/404
CPC分类号: A61K31/404 , A61K9/2018 , A61K9/205
摘要: The present invention relates to a method of treating a cachexia and/or sarcopenia with an oral dose of S-pindolol or a pharmaceutical formulation thereof and to an oral formulation for use in said method of treatment. The method and oral formulation comprise administering a total daily dose of 2.5 to 20 mg of S-pindolol or a pharmaceutical formulation comprising the same.
摘要翻译: 本发明涉及用口服剂量的S-哌哚洛尔或其药物制剂和用于所述治疗方法的口服制剂治疗恶病质和/或肌营养不良的方法。 该方法和口服制剂包括施用2.5至20mg的S-日吲哚的总日剂量或包含其的药物制剂。
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公开(公告)号:US20100175699A1
公开(公告)日:2010-07-15
申请号:US12595536
申请日:2008-04-10
申请人: Mark Varney , Michael Garrett , Deryk Williams , John Beadle
发明人: Mark Varney , Michael Garrett , Deryk Williams , John Beadle
CPC分类号: A61B5/0816 , A61B5/087 , A61B5/4806 , A61B5/4818 , A61M16/024 , A61M16/0672 , A61M16/08 , A61M16/161 , A61M2016/0036 , A61M2202/062 , A61M2205/0233 , A61M2205/0244 , A61M2205/3317 , A61M2205/502 , A61M2205/8206 , A61M2230/30 , A61M2230/42 , A61M2230/435 , G01N27/121
摘要: A sensor assembly for monitoring the respiration pattern of a subject is disclosed, the sensor comprising a sensor element for exposing to a gas stream exhaled by the subject comprising a first electrode, a second electrode and an active layer extending between the first and second electrodes to provide an electrical path therebetween, the sensor element being responsive to the concentration of water vapour in the gas stream exhaled by the subject, whereby the conductivity of the path between the electrodes varies in response to changes in the concentration of water vapour; a processor for determining the pattern of respiration of the subject; and means for displaying information relating to the determined respiration pattern to a user. The sensor assembly is particular suitable for measuring the respiration rate and/or depth of respiration of the subject. The sensor and method find particular application in the diagnosis and treatment of sleep apnea.
摘要翻译: 公开了一种用于监测受试者的呼吸模式的传感器组件,该传感器包括用于暴露于受试者呼出的气流的传感器元件,包括第一电极,第二电极和在第一和第二电极之间延伸的有源层, 在它们之间提供电气路径,所述传感器元件响应受试者呼出的气流中的水蒸气的浓度,由此电极之间的路径的导电性响应于水蒸汽浓度的变化而变化; 用于确定所述对象的呼吸模式的处理器; 以及用于向用户显示与确定的呼吸模式相关的信息的装置。 传感器组件特别适于测量受试者的呼吸速率和/或呼吸深度。 传感器和方法在睡眠呼吸暂停的诊断和治疗中有特别的应用。
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