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8 条记录 (耗时 0.015 秒)

    Method of Treating Cachexia and Sarcopenia
    3.
    发明申请
    Method of Treating Cachexia and Sarcopenia 审中-公开
    治疗恶病质和症状的方法

    公开(公告)号：US20140194484A1

    公开(公告)日：2014-07-10

    申请号：US14101272

    申请日：2013-12-09

    申请人： Andrew Coats ,  John Beadle ,  Stefan Anker

    发明人： Andrew Coats ,  John Beadle ,  Stefan Anker

    IPC分类号： A61K31/404

    CPC分类号： A61K31/404 ,  A61K9/2018 ,  A61K9/205

    摘要： The present invention relates to a method of treating a cachexia and/or sarcopenia with an oral dose of S-pindolol or a pharmaceutical formulation thereof and to an oral formulation for use in said method of treatment. The method and oral formulation comprise administering a total daily dose of 2.5 to 20 mg of S-pindolol or a pharmaceutical formulation comprising the same.

    摘要翻译： 本发明涉及用口服剂量的S-哌哚洛尔或其药物制剂和用于所述治疗方法的口服制剂治疗恶病质和/或肌营养不良的方法。 该方法和口服制剂包括施用2.5至20mg的S-日吲哚的总日剂量或包含其的药物制剂。

    Therapy and Use of Compounds in Therapy
    4.
    发明申请
    Therapy and Use of Compounds in Therapy 审中-公开
    治疗和化合物在治疗中的应用

    公开(公告)号：US20070197485A1

    公开(公告)日：2007-08-23

    申请号：US11627183

    申请日：2007-01-25

    申请人： Stefan Anker ,  Andrew Coats ,  Hans-Dieter Volk ,  Ralf Schuman ,  Mathias Plauth ,  Herbert Lochs

    发明人： Stefan Anker ,  Andrew Coats ,  Hans-Dieter Volk ,  Ralf Schuman ,  Mathias Plauth ,  Herbert Lochs

    IPC分类号： A61K31/56

    CPC分类号： A61K31/575

    摘要： A method for treating cachecia, liver disease, and other wasting syndromes is provided. The treatment method comprises administering a therapeutically effective amount of a compound that is able to reduce the production, absorption and/or the effect of an endotoxin. Examples of such compounds include, but are not limited to, bile acids; bactericidal/permeability increasing proteins; lipoproteins; antibodies capable of binding to endotoxins; LPS binding protein; activated charcoal, Fuller's earth, attapulgite, kaolin or bentonite or a clay; a drug blocking effectively signaling through toll-like receptors; and calostrum or human, bovine or other mammals.

    摘要翻译： 提供了一种治疗缓解期，肝病和其他消瘦综合征的方法。 治疗方法包括施用治疗有效量的能够降低内毒素的产生，吸收和/或作用的化合物。 这些化合物的实例包括但不限于胆汁酸; 杀菌/渗透性增加蛋白质; 脂蛋白; 能够结合内毒素的抗体; LPS结合蛋白; 活性炭，富勒土，绿坡缕石，高岭土或膨润土或粘土; 药物阻断通过收费样受体有效发信号; 和饮水或人，牛或其他哺乳动物。

    COFFEE MAKER
    7.
    发明申请
    COFFEE MAKER 审中-公开
    咖啡机

    公开(公告)号：US20130019756A1

    公开(公告)日：2013-01-24

    申请号：US13186691

    申请日：2011-07-20

    申请人： Andrew Coats ,  Benjamin Salinas ,  George Harris ,  Robert Macklin ,  Carl Tappan

    发明人： Andrew Coats ,  Benjamin Salinas ,  George Harris ,  Robert Macklin ,  Carl Tappan

    IPC分类号： A47J31/047

    CPC分类号： A47J31/56 ,  A47J31/04 ,  A47J31/0621 ,  A47J31/0631 ,  A47J31/34

    摘要： A coffee maker with continuously adjustable water flow rate, continuously adjustable feedback-controlled water temperature, and low thermal mass allows baristas to experiment with and digitally program and/or record different flow-rate and temperature profiles (brewing profiles) over the course of brewing a cup or batch of coffee. Brewing profiles may be recorded on one machine and reproduced (played back) on another machine, allowing reproducibility of subtle flavor variations in brewed coffee.

    摘要翻译： 具有连续可调的水流速度，连续可调的反馈控制水温和低热量的咖啡机允许咖啡师在酿造过程中实验和数字编程和/或记录不同的流速和温度曲线（酿造曲线） 一杯或一批咖啡。 酿造简档可以记录在一台机器上并在另一台机器上再现（播放），从而允许酿造咖啡中微妙的风味变化的重复性。

    THERAPY AND USE OF COMPOUNDS IN THERAPY
    8.
    发明申请
    THERAPY AND USE OF COMPOUNDS IN THERAPY 审中-公开
    治疗方法和化疗方法的使用

    公开(公告)号：US20090197851A1

    公开(公告)日：2009-08-06

    申请号：US12187169

    申请日：2008-08-06

    申请人： Stefan Anker ,  Andrew Coats ,  Hans-Dieter Volk ,  Mathias Rauchhaus ,  Ralf Reiner Schumann

    发明人： Stefan Anker ,  Andrew Coats ,  Hans-Dieter Volk ,  Mathias Rauchhaus ,  Ralf Reiner Schumann

    IPC分类号： A61K31/575 ,  A61P9/00

    CPC分类号： A61K31/575

    摘要： A method of treating, preventing or ameliorating chronic heart failure or acute heart failure in a patient the method comprising administering to the patient an effective amount of: a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule, for example LPS binding protein, BPI, lipoproteins, bile acids or an antibody capable of binding LPS, a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule or bacterium in the gut, for example charcoal, a bile acid or Fuller's earth, an antibacterial agent that is substantially active in the gut, an agent that is able to inhibit the response by a cell to endotoxin (lipopolysaccharide; LPS), an agent that may form a barrier or that otherwise impedes translocation of bacteria or endotoxin (LPS) from the gut into the patient's circulation. A method of treating, preventing or ameliorating endotoxin-mediated immune activation in acute or chronic heart failure in a patient the method comprising administering to the patient an effective amount of: a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule, for example LPS binding protein, BPI, lipoproteins, bile acids or an antibody capable of binding LPS, a compound that is able to bind to an endotoxin (lipopolysaccharide; LPS) molecule or bacterium in the gut, for example charcoal, a bile acid or Fuller's earth, an antibacterial agent that is substantially active in the gut, an agent that is able to inhibit the response by a cell to endotoxin (lipopolysaccharide; LPS), an agent that may form a barrier or that otherwise impedes translocation of bacteria or endotoxin (LPS) from the gut into the patient's circulation.

    摘要翻译： 一种治疗，预防或改善患者的慢性心力衰竭或急性心力衰竭的方法，该方法包括向患者施用有效量的：能够结合内毒素（脂多糖; LPS）分子的化合物，例如LPS 结合蛋白质，BPI，脂蛋白，胆汁酸或能够结合LPS的抗体，能够结合肠中的内毒素（脂多糖; LPS）分子或细菌的化合物，例如活性炭，胆汁酸或富勒氏土， 在肠道中基本上具有活性的抗菌剂，能够抑制细胞对内毒素（脂多糖; LPS）的反应的试剂，可能形成屏障或另外阻碍细菌或内毒素（LPS）易位的药剂， 从肠道到患者的流通。 一种在患者急性或慢性心力衰竭中治疗，预防或改善内毒素介导的免疫激活的方法，该方法包括向患者施用有效量的：能够结合内毒素（脂多糖; LPS）分子的化合物 ，例如LPS结合蛋白，BPI，脂蛋白，胆汁酸或能够结合LPS的抗体，能够结合肠中的内毒素（脂多糖; LPS）分子或细菌的化合物，例如活性炭，胆汁酸 或富勒的地球，在肠中基本上具有活性的抗菌剂，能够抑制细胞对内毒素（脂多糖; LPS）的反应的试剂，可能形成屏障或以其它方式阻碍细菌易位的药剂或 内毒素（LPS）从肠道进入患者的循环。