公开(公告)号：US20140045813A1

公开(公告)日：2014-02-13

申请号：US13962260

申请日：2013-08-08

申请人： Joerg Martin BENTZIEN ,  Angela Kay BERRY ,  Todd BOSANAC ,  Michael Jason BURKE ,  Darren Todd DISALVO ,  Joshua Courtney HORAN ,  Shuang LIANG ,  Can MAO ,  Wang MAO ,  Yue SHEN ,  Fariba SOLEYMANZADEH ,  Renee M. ZINDELL

发明人： Joerg Martin BENTZIEN ,  Angela Kay BERRY ,  Todd BOSANAC ,  Michael Jason BURKE ,  Darren Todd DISALVO ,  Joshua Courtney HORAN ,  Shuang LIANG ,  Can MAO ,  Wang MAO ,  Yue SHEN ,  Fariba SOLEYMANZADEH ,  Renee M. ZINDELL

IPC分类号： C07D231/14 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/06 ,  C07D277/56 ,  C07D417/04 ,  C07D403/06 ,  C07D401/06 ,  C07D401/04 ,  C07D403/04

CPC分类号： C07D417/08 ,  C07D231/14 ,  C07D231/38 ,  C07D231/40 ,  C07D277/56 ,  C07D401/02 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/08 ,  C07D405/14 ,  C07D413/14 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06

摘要： The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.

摘要翻译： 本发明包括其中本文定义的基团A，Cy，X 1和Y的式（I）的化合物，其适用于治疗与BTK相关的疾病，制备方法，含有化合物的药物制剂及其方法 使用。

公开(公告)号：US20190023686A1

公开(公告)日：2019-01-24

申请号：US16069046

申请日：2017-01-12

申请人： Todd BOSANAC ,  Joerg BENTZIEN ,  Michael Jason BURKE ,  Darren Todd DISALVO ,  Wang MAO ,  Fariba SOLEYMANZADEH ,  John WESTBROOK ,  Zhaoming XIONG ,  Boehringer Ingelheim International GmbH

发明人： Todd BOSANAC ,  Joerg BENTZIEN ,  Michael Jason BURKE ,  Darren Todd DISALVO ,  Wang MAO ,  Fariba SOLEYMANZADEH ,  John A. WESTBROOK ,  Zhaoming XIONG

IPC分类号： C07D401/14

摘要： The present invention encompasses compounds of the formula (I) wherein the groups R1, R2, R3, R4 and R5 are defined herein, which are suitable for the treatment of diseases related to Bruton's tyrosine kinase (BTK), and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.