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公开(公告)号：US08148076B2
公开(公告)日：2012-04-03
申请号：US13150799
申请日：2011-06-01
申请人： Joffre B. Baker , Maureen T. Cronin , Steven Shak , Jose Baselga
发明人： Joffre B. Baker , Maureen T. Cronin , Steven Shak , Jose Baselga
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
摘要翻译： 本发明涉及与EGFR阳性癌症相关的预后标志物。 特别地，本发明涉及基于在石蜡包埋的EGFR表达癌症的固定组织样品中的基因表达的分子表征的预后方法，其允许医师预测患者是否可能对EGFR抑制剂的治疗反应良好 。
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公开(公告)号：US20120178644A1
公开(公告)日：2012-07-12
申请号：US13347555
申请日：2012-01-10
申请人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
发明人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
摘要翻译： 本发明涉及与EGFR阳性癌症相关的预后标志物。 特别地，本发明涉及基于在石蜡包埋的EGFR表达癌症的固定组织样品中的基因表达的分子表征的预后方法，其允许医师预测患者是否可能对EGFR抑制剂的治疗反应良好 。
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公开(公告)号：US20110245102A1
公开(公告)日：2011-10-06
申请号：US13150799
申请日：2011-06-01
申请人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
发明人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
摘要翻译： 本发明涉及与EGFR阳性癌症相关的预后标志物。 特别地，本发明涉及基于在石蜡包埋的EGFR表达癌症的固定组织样品中的基因表达的分子表征的预后方法，其允许医师预测患者是否可能对EGFR抑制剂的治疗反应良好 。
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公开(公告)号：US08008003B2
公开(公告)日：2011-08-30
申请号：US10714195
申请日：2003-11-14
申请人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
发明人： Joffre B. Baker , Maureen T. Cronin , Steve Shak , Jose Baselga
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/16
摘要： The present invention concerns prognostic markers associated with EGFR positive cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed tissue samples of EGFR-expressing cancer, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
摘要翻译： 本发明涉及与EGFR阳性癌症相关的预后标志物。 特别地，本发明涉及基于在石蜡包埋的EGFR表达癌症的固定组织样品中的基因表达的分子表征的预后方法，其允许医师预测患者是否可能对EGFR抑制剂的治疗反应良好 。
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公开(公告)号：US08034565B2
公开(公告)日：2011-10-11
申请号：US12478632
申请日：2009-06-04
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
摘要翻译： 本发明提供了在乳腺癌的诊断和/或预后中重要的基因组。
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公开(公告)号：US10241114B2
公开(公告)日：2019-03-26
申请号：US11450896
申请日：2006-06-09
IPC分类号： C12Q1/68 , G01N33/574 , C12N15/10 , C12Q1/6886
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
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公开(公告)号：US07838224B2
公开(公告)日：2010-11-23
申请号：US11450962
申请日：2006-06-09
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
摘要翻译： 本发明涉及测量活检肿瘤组织中的mRNA水平的敏感方法，包括归档石蜡包埋的活检材料。 本发明还涉及在乳腺癌诊断和治疗中重要的乳腺癌基因集，以及基于从基因表达研究获得的知识为乳腺癌患者分配最佳治疗选择的方法。
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公开(公告)号：US20100209920A1
公开(公告)日：2010-08-19
申请号：US12616039
申请日：2009-11-10
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
摘要翻译： 本发明涉及测量活检肿瘤组织中的mRNA水平的敏感方法，包括归档石蜡包埋的活检材料。 本发明还涉及在乳腺癌诊断和治疗中重要的乳腺癌基因集，以及基于从基因表达研究获得的知识为乳腺癌患者分配最佳治疗选择的方法。
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公开(公告)号：US07569345B2
公开(公告)日：2009-08-04
申请号：US10758307
申请日：2004-01-14
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
摘要翻译： 本发明提供了在乳腺癌的诊断和/或预后中重要的基因组。
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公开(公告)号：US20080182255A1
公开(公告)日：2008-07-31
申请号：US11931441
申请日：2007-10-31
CPC分类号： G01N33/57484 , C12N15/1003 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415
摘要： The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.
摘要翻译： 本发明涉及测量活检肿瘤组织中的mRNA水平的敏感方法，包括归档石蜡包埋的活检材料。 本发明还涉及在乳腺癌诊断和治疗中重要的乳腺癌基因集，以及基于从基因表达研究获得的知识为乳腺癌患者分配最佳治疗选择的方法。
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