公开(公告)号：US06200532B1

公开(公告)日：2001-03-13

申请号：US09197481

申请日：1998-11-20

申请人： Jogin R. Wu ,  Mario Moreno

发明人： Jogin R. Wu ,  Mario Moreno

IPC分类号： G01N3300

CPC分类号： G01N29/036 ,  G01N33/4905 ,  G01N2291/0256

摘要： A device and method for performing blood coagulation assays, particularly prothrombin times and activated partial thromboplastin times and other clotting parameters are disclosed. The device comprises a disposable strip (containing a sample inlet for sample delivery, a capillary channel for driving force, and a reaction chamber with an appropriate dry reagent for a specific assay) and a piezoelectric sensor. The device could also include a heating element for temperature control, and a magnetic bender. The magnetic bender is driven by an electromagnetic field generator and is attached onto a piezoelectric film in contact with the blood sample. Electric signal generated at the piezo film is characterized by its frequency and amplitude due to the movement of the attached metal film. The signal collected at the site of the piezo film represents the process of a biochemical reaction in the reaction chamber, while blood sample proceeds to the point at which clot formation starts and is amplified by an amplifier and rectified into a Dc voltage and is sent to a recording unit and/or display unit.

摘要翻译： 公开了一种用于进行凝血测定，特别是凝血酶原时间和活化的部分凝血活酶时间和其它凝血参数的装置和方法。 该装置包括一次性带（包含用于样品输送的样品入口，用于驱动力的毛细通道，以及具有用于特定测定的合适的干试剂的反应室）和压电传感器。 该装置还可以包括用于温度控制的加热元件和磁性弯曲机。 磁弯曲机由电磁场发生器驱动，并附着在与血液样品接触的压电膜上。 在压电膜处产生的电信号的特征在于由于附着的金属膜的移动而引起的频率和振幅。 在压电薄膜部位收集的信号代表反应室中生化反应的过程，而血液样品进入凝块形成开始点并被放大器放大并整流成Dc电压，并送至 记录单元和/或显示单元。

公开(公告)号：US5908786A

公开(公告)日：1999-06-01

申请号：US989561

申请日：1997-12-12

申请人： Mario Moreno ,  Jogin R. Wu

发明人： Mario Moreno ,  Jogin R. Wu

IPC分类号： G01N33/86

CPC分类号： G01N33/86 ,  Y10T436/25375 ,  Y10T436/255

摘要： A device and method are disclosed for determining whether or not an individual's blood coagulation time is in a normal or abnormal range, and is particularly suitable for measuring prothrombin time and activated partial thromboplastin time coagulation values. The device includes a housing with an area for receiving a sample, a capillary channel or elongated area with an absorbent material, and a gradient heater. Liquid crystal and a coagulation agent can be disposed within the device to mix with a sample added to the device. The mixture passes along the capillary channel or absorbent material and stops moving when the sample has clotted. Due to the gradient heater and liquid crystal, the mixture may or may not change color, depending upon whether the individual has a an abnormally short, normal, or abnormally long clot time.

摘要翻译： 公开了一种用于确定个体的血液凝固时间是否处于正常或异常范围的装置和方法，并且特别适合于测量凝血酶原时间和活化的部分凝血活酶时间凝结值。 该装置包括具有用于接收样品的区域的壳体，具有吸收材料的毛细通道或细长区域和梯度加热器。 可以将液晶和凝结剂置于装置内以与添加到装置中的样品混合。 混合物沿着毛细通道或吸收材料通过，并且当样品凝结时停止移动。 由于梯度加热器和液晶，根据个体是否具有异常短，正常或异常长的凝血时间，混合物可能或可能不会改变颜色。