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1.发明授权
公开(公告)号：US5716789A
公开(公告)日：1998-02-10
申请号：US476000
申请日：1995-06-07
CPC分类号： C07K7/06 , C07K14/705 , C07K14/723 , C07K7/08 , A61K38/00 , A61K48/00 , G01N2333/726 , G01N2500/00
摘要： Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
摘要翻译： 编码C140细胞表面受体的核酸分子已被克隆并测序。 C140受体DNA的可用性允许重组产生可在细胞表面（包括卵母细胞）上产生的C140受体。 核酸分子可用于检测影响C140受体活性的物质，即受体激动剂或拮抗剂。 此外，阐明C140受体的结构允许设计可用于此类测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与C140受体的一个或多个抗原表位特异性免疫反应的抗体。
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公开(公告)号：US06297026B1
公开(公告)日：2001-10-02
申请号：US08486673
申请日：1995-06-07
IPC分类号： C12N1512
CPC分类号： C07K7/06 , A61K38/00 , A61K48/00 , C07K7/08 , C07K14/705 , C07K14/723 , G01N2333/726 , G01N2500/00
摘要： Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
摘要翻译： 编码C140细胞表面受体的核酸分子已被克隆并测序。 C140受体DNA的可用性允许重组产生可在细胞表面（包括卵母细胞）上产生的C140受体。 核酸分子可用于检测影响C140受体活性的物质，即受体激动剂或拮抗剂。 此外，阐明C140受体的结构允许设计可用于此类测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与C140受体的一个或多个抗原表位特异性免疫反应的抗体。
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3.发明授权
公开(公告)号：US6043212A
公开(公告)日：2000-03-28
申请号：US474410
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K48/00 , C07K7/06 , C07K7/08 , C07K14/72 , C12N15/12 , A61K38/03 , A61K38/08 , A61K38/10
CPC分类号： C07K7/06 , C07K14/705 , C07K14/723 , C07K7/08 , A61K38/00 , A61K48/00 , G01N2333/726 , G01N2500/00
摘要： Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
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公开(公告)号：US5763575A
公开(公告)日：1998-06-09
申请号：US472840
申请日：1995-06-07
CPC分类号： C07K7/06 , C07K14/705 , C07K14/723 , C07K7/08 , A61K38/00 , A61K48/00 , G01N2333/726 , G01N2500/00
摘要： Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
摘要翻译： 编码C140细胞表面受体的核酸分子已被克隆并测序。 C140受体DNA的可用性允许重组产生可在细胞表面（包括卵母细胞）上产生的C140受体。 核酸分子可用于检测影响C140受体活性的物质，即受体激动剂或拮抗剂。 此外，阐明C140受体的结构允许设计可用于此类测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与C140受体的一个或多个抗原表位特异性免疫反应的抗体。
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公开(公告)号：US5629174A
公开(公告)日：1997-05-13
申请号：US97938
申请日：1993-07-26
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/705 , C07K14/72 , C07K16/28 , C12N5/10 , C12P21/02 , C12R1/91 , C12N15/63
CPC分类号： C07K7/06 , C07K14/723 , C07K7/08 , A61K38/00 , A61K48/00
摘要： The DNA encoding the C140 cell surface receptor has been cloned and sequenced. The availability of this DNA permits the recombinant production of the C140 receptor which can be produced at cell or oocyte surfaces and is useful in assay systems both for the detection of substances which affect its activity, including agonists and antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in these assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof.
摘要翻译： 编码C140细胞表面受体的DNA已被克隆并测序。 该DNA的可用性允许重组产生可在细胞或卵母细胞表面产生的C140受体，并且可用于检测影响其活性的物质（包括激动剂和拮抗剂）的测定系统中。 此外，阐明C140受体的结构允许设计可用于这些测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与受体本身或其特定区域特异性免疫反应的抗体。
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6.发明授权
公开(公告)号：US5874400A
公开(公告)日：1999-02-23
申请号：US476976
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K48/00 , C07K7/06 , C07K7/08 , C07K14/72 , C12N15/12 , A61K39/395 , C07K16/28 , G01N33/53
CPC分类号： C07K7/06 , C07K14/705 , C07K14/723 , C07K7/08 , A61K38/00 , A61K48/00 , G01N2333/726 , G01N2500/00
摘要： Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
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7.发明授权Recombinant C140 receptor, its agonists and antagonists, and nucleic acids encoding the receptor 失效重组C140受体，其激动剂和拮抗剂，以及编码受体的核酸公开(公告)号：US07834143B2
公开(公告)日：2010-11-16
申请号：US11827396
申请日：2007-07-11
IPC分类号： C07K7/00 , C07K7/06 , C07K7/08 , C07K14/705 , C07K14/47
CPC分类号： C07K7/06 , A61K38/00 , A61K48/00 , C07K7/08 , C07K14/705 , C07K14/723 , G01N2333/726 , G01N2500/00
摘要： Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
摘要翻译： 编码C140细胞表面受体的核酸分子已被克隆并测序。 C140受体DNA的可用性允许重组产生可在细胞表面（包括卵母细胞）上产生的C140受体。 核酸分子可用于检测影响C140受体活性的物质，即受体激动剂或拮抗剂。 此外，阐明C140受体的结构允许设计可用于此类测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与C140受体的一个或多个抗原表位特异性免疫反应的抗体。
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8.发明授权Recombinant C140 receptor, its agonists and antagonists, and nucleic acids encoding the receptor 失效重组C140受体，其激动剂和拮抗剂，以及编码受体的核酸公开(公告)号：US07351792B2
公开(公告)日：2008-04-01
申请号：US10643627
申请日：2003-08-19
IPC分类号： C07K7/08 , C07K7/00 , C07K7/06 , C07K14/705 , C07K14/435 , A61K38/00
CPC分类号： C07K7/06 , A61K38/00 , A61K48/00 , C07K7/08 , C07K14/705 , C07K14/723 , G01N2333/726 , G01N2500/00
摘要： Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
摘要翻译： 编码C140细胞表面受体的核酸分子已被克隆并测序。 C140受体DNA的可用性允许重组产生可在细胞表面（包括卵母细胞）上产生的C140受体。 核酸分子可用于检测影响C140受体活性的物质，即受体激动剂或拮抗剂。 此外，阐明C140受体的结构允许设计可用于此类测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与C140受体的一个或多个抗原表位特异性免疫反应的抗体。
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9.发明申请Recombinant C140 Receptor, it's agonists and antagonists, and nucleic acids encoding the receptor 失效重组C140受体，它是激动剂和拮抗剂，以及编码受体的核酸公开(公告)号：US20080108788A1
公开(公告)日：2008-05-08
申请号：US11827396
申请日：2007-07-11
申请人： Johan Sundelin , Robert Scarborough
发明人： Johan Sundelin , Robert Scarborough
CPC分类号： C07K7/06 , A61K38/00 , A61K48/00 , C07K7/08 , C07K14/705 , C07K14/723 , G01N2333/726 , G01N2500/00
摘要： Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
摘要翻译： 编码C140细胞表面受体的核酸分子已被克隆并测序。 C140受体DNA的可用性允许重组产生可在细胞表面（包括卵母细胞）上产生的C140受体。 核酸分子可用于检测影响C140受体活性的物质，即受体激动剂或拮抗剂。 此外，阐明C140受体的结构允许设计可用于此类测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与C140受体的一个或多个抗原表位特异性免疫反应的抗体。
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10.发明申请Recombinant C140 receptor, its agonists and antagonists, and nucleic acids encoding the receptor 失效重组C140受体，其激动剂和拮抗剂，以及编码受体的核酸公开(公告)号：US20050080234A1
公开(公告)日：2005-04-14
申请号：US10643627
申请日：2003-08-19
申请人： Johan Sundelin , Robert Scarborough
发明人： Johan Sundelin , Robert Scarborough
IPC分类号： A61K38/00 , A61K48/00 , C07K7/06 , C07K7/08 , C07K14/72 , C12N15/12 , C07K14/705 , C07H21/04
CPC分类号： C07K7/06 , A61K38/00 , A61K48/00 , C07K7/08 , C07K14/705 , C07K14/723 , G01N2333/726 , G01N2500/00
摘要： Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyte. The nucleic acid molecules are useful in an assay for detecting a substance which affects C140 receptor activity, either receptor agonists or antagonists. Further, the elucidation of the structure of the C140 receptor permits the design of agonist and antagonist compounds which are useful in such assays. The availability of the C140 receptor also permits production of antibodies specifically immunoreactive with one or more antigenic epitopes of the C140 receptor.
摘要翻译： 编码C140细胞表面受体的核酸分子已被克隆并测序。 C140受体DNA的可用性允许重组产生可在细胞表面（包括卵母细胞）上产生的C140受体。 核酸分子可用于检测影响C140受体活性的物质，即受体激动剂或拮抗剂。 此外，阐明C140受体的结构允许设计可用于此类测定中的激动剂和拮抗剂化合物。 C140受体的可用性还允许产生与C140受体的一个或多个抗原表位特异性免疫反应的抗体。
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