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公开(公告)号：US20150045325A1
公开(公告)日：2015-02-12
申请号：US14525396
申请日：2014-10-28
申请人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
发明人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
CPC分类号： C07F9/60 , A61K31/662 , A61K45/06 , C07F9/3808 , C07F9/3834 , Y02A50/395
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译： 本发明包括由下式表示的新一类化合物，它们是PTP-1B酶的抑制剂。 本发明还包括药物组合物，其包括上述化合物（式I）和治疗或预防PTP-1B介导的疾病包括糖尿病的方法。
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公开(公告)号：US08168815B2
公开(公告)日：2012-05-01
申请号：US12518899
申请日：2008-01-24
申请人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
发明人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
IPC分类号： C07D215/38
CPC分类号： C07F9/60 , A61K31/662 , A61K45/06 , C07F9/3808 , C07F9/3834 , Y02A50/395
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译： 本发明包括由下式表示的新一类化合物，它们是PTP-1B酶的抑制剂。 本发明还包括药物组合物，其包括上述化合物（式I）和治疗或预防PTP-1B介导的疾病包括糖尿病的方法。
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公开(公告)号：US20100022477A1
公开(公告)日：2010-01-28
申请号：US12518899
申请日：2008-01-24
申请人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
发明人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
CPC分类号： C07F9/60 , A61K31/662 , A61K45/06 , C07F9/3808 , C07F9/3834 , Y02A50/395
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译： 本发明包括由下式表示的新一类化合物，它们是PTP-1B酶的抑制剂。 本发明还包括药物组合物，其包括上述化合物（式I）和治疗或预防PTP-1B介导的疾病包括糖尿病的方法。
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公开(公告)号：US08481742B2
公开(公告)日：2013-07-09
申请号：US13418956
申请日：2012-03-13
申请人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
发明人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： C07F9/60 , A61K31/662 , A61K45/06 , C07F9/3808 , C07F9/3834 , Y02A50/395
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
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公开(公告)号：US09334295B2
公开(公告)日：2016-05-10
申请号：US14525396
申请日：2014-10-28
申请人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
发明人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
IPC分类号： A61K31/662 , C07F9/60 , C07F9/38 , A61K45/06
CPC分类号： C07F9/60 , A61K31/662 , A61K45/06 , C07F9/3808 , C07F9/3834 , Y02A50/395
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
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公开(公告)号：US08927526B2
公开(公告)日：2015-01-06
申请号：US13898947
申请日：2013-05-21
申请人： John Colucci , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
发明人： John Colucci , Marie-Claire Wilson , Yongxin Han , Claude Dufresne , Michel Belley , Cheuk K. Lau , Christopher Bayly
IPC分类号： C07F9/60 , C07F9/38 , A61K31/662 , A61K45/06
CPC分类号： C07F9/60 , A61K31/662 , A61K45/06 , C07F9/3808 , C07F9/3834 , Y02A50/395
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译： 本发明包括由下式表示的新一类化合物，它们是PTP-1B酶的抑制剂。 本发明还包括药物组合物，其包括上述化合物（式I）和治疗或预防PTP-1B介导的疾病包括糖尿病的方法。
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公开(公告)号：US5472964A
公开(公告)日：1995-12-05
申请号：US260592
申请日：1994-06-16
申请人： Robert N. Young , Marc Labelle , Yves Leblanc , Yi B. Xiang , Cheuk K. Lau , Claude Dufresne , Yves Gareau
发明人： Robert N. Young , Marc Labelle , Yves Leblanc , Yi B. Xiang , Cheuk K. Lau , Claude Dufresne , Yves Gareau
IPC分类号： C07D513/04 , A61K31/44 , A61K45/06 , A61P11/06 , A61P27/02 , A61P29/00 , A61P37/08 , A61P43/00 , C07D491/04 , C07D491/048 , C07D495/04 , A61K31/435
CPC分类号： C07D491/04 , C07D495/04 , C07D513/04
摘要： Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
摘要翻译： 具有式I的化合物：I是白三烯的作用的拮抗剂。 这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。 它们也可用于治疗心绞痛，脑痉挛，肾小球肾炎，肝炎，内毒素血症，葡萄膜炎和同种异体移植排斥。
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8.发明授权Phosphonic acids derivatives as inhibitors of protein tyrosine phosphate 1B (PTP-1B) 失效磷酸衍生物作为蛋白质酪氨酸磷酸1B（PTP-1B）的抑制剂公开(公告)号：US06174874B1
公开(公告)日：2001-01-16
申请号：US09398356
申请日：1999-09-17
申请人： Zhaoyin Wang , Claude Dufresne , Yves Leblanc , Chun Sing Li , Jacques Y. Gauthier , Cheuk K. Lau , Michel Therien , Patrick Roy
发明人： Zhaoyin Wang , Claude Dufresne , Yves Leblanc , Chun Sing Li , Jacques Y. Gauthier , Cheuk K. Lau , Michel Therien , Patrick Roy
IPC分类号： A61K31663
CPC分类号： H04M3/42314 , C07F9/3856 , C07F9/386 , C07F9/3865 , C07F9/3869 , C07F9/3882 , C07F9/5537 , C07F9/65068 , C07F9/65188 , C07F9/6524 , C07F9/65318 , C07F9/65324 , C07F9/6539 , C07F9/65395 , C07F9/6541 , H04Q3/625 , H04Q2213/13104 , H04Q2213/13107 , H04Q2213/1322 , H04Q2213/1329 , H04Q2213/13389
摘要： The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.
摘要翻译： 本发明包括作为PTP-1B酶抑制剂的由式I表示的新一类化合物。本发明还包括治疗或预防PTP-1B介导的疾病的药物组合物和方法。
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公开(公告)号：US07163932B2
公开(公告)日：2007-01-16
申请号：US10481485
申请日：2002-06-19
申请人： Claude Dufresne , Yves Leblanc , Cheuk K. Lau , Patrick Roy , Chun Sing Li
发明人： Claude Dufresne , Yves Leblanc , Cheuk K. Lau , Patrick Roy , Chun Sing Li
CPC分类号： C07F9/3882 , C07F9/5537
摘要： The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
摘要翻译： 本发明包括由下式表示的新一类化合物，它们是PTP-1B酶的抑制剂。 本发明还包括药物组合物，其包括上述化合物和治疗或预防PTP-1B介导的疾病，包括糖尿病的方法。
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10.发明授权5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors 失效5-羟基-2,3-二氢苯并呋喃类似物作为紫苏酮生物合成抑制剂
公开(公告)号：US5091533A
公开(公告)日：1992-02-25
申请号：US491799
申请日：1990-03-12
申请人： Patrice C. Belanger , Claude Dufresne , Brian Fitzsimmons, deceased , Maryann Fitzsimmons, Heir , Yvan Guindon , Cheuk K. Lau , Joshua Rokach , John Schiegetz , Michel Therien , Robert N. Young
发明人： Patrice C. Belanger , Claude Dufresne , Brian Fitzsimmons, deceased , Maryann Fitzsimmons, Heir , Yvan Guindon , Cheuk K. Lau , Joshua Rokach , John Schiegetz , Michel Therien , Robert N. Young
IPC分类号： A61K31/34 , A61K31/343 , A61P9/00 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07D307/79 , C07D307/80 , C07D307/83 , C07D405/12 , C07D417/12
CPC分类号： C07D307/79 , C07D307/80 , C07D405/12 , C07D417/12
摘要： Compounds of the formula: ##STR1## where R.sup.2 contains certain aryls or heteroaryls are effective leukotriene inhibitors.
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