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    Quinoline derivatives as EP4 antagonists
    7.
    发明授权
    Quinoline derivatives as EP4 antagonists 有权
    喹啉衍生物作为EP4拮抗剂

    公开(公告)号：US08013159B2

    公开(公告)日：2011-09-06

    申请号：US11920275

    申请日：2006-05-15

    申请人： Michel Belley ,  Jason Burch ,  John Colucci ,  Julie Farand ,  Mario Girard ,  Yongxin Han

    发明人： Michel Belley ,  Jason Burch ,  John Colucci ,  Julie Farand ,  Mario Girard ,  Yongxin Han

    IPC分类号： C07D471/00

    CPC分类号： C07D471/04

    摘要： The invention is directed to quinoline derivatives as prostaglandin E type receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. The derivatives have the following structure of formula (I): wherein A and B represents either a nitrogen atom or a CH group with the proviso that they cannot both simultaneously be CH, Q can represent a nitrogen or a carbon atom, and Y and Z are either a nitrogen atom, a N(O) group or a C(R5) group. Pharmaceutical compositions comprising the derivatives of formula (I) are also included.

    摘要翻译： 本发明涉及可用于治疗EP4介导的疾病或病症（例如急性和慢性疼痛，骨关节炎，类风湿性关节炎和癌症）的前列腺素E型受体拮抗剂的喹啉衍生物。 衍生物具有式（I）的以下结构：其中A和B表示氮原子或CH基团，条件是它们不能同时为CH，Q可以表示氮或碳原子，Y和Z 是氮原子，N（O）基或C（R5）基团。 还包括包含式（I）的衍生物的药物组合物。

    Quinoline derivatives as ep4 antagonists
    8.
    发明申请
    Quinoline derivatives as ep4 antagonists 有权
    喹啉衍生物作为ep4拮抗剂

    公开(公告)号：US20090099226A1

    公开(公告)日：2009-04-16

    申请号：US11920275

    申请日：2006-05-15

    申请人： Michel Belley ,  Jason Burch ,  John Colucci ,  Julie Farand ,  Mario Girard ,  Yongxin Han

    发明人： Michel Belley ,  Jason Burch ,  John Colucci ,  Julie Farand ,  Mario Girard ,  Yongxin Han

    IPC分类号： A61K31/437 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention is directed to quinoline derivatives as prostaglandin E type receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. The derivatives have the following structure of formula (I): wherein A and B represents either a nitrogen atom or a CH group with the proviso that they cannot both simultaneously be CH, Q can represent a nitrogen or a carbon atom, and Y and Z are either a nitrogen atom, a N(O) group or a C(R5) group. Pharmaceutical compositions comprising the derivatives of formula (I) are also included.

    摘要翻译： 本发明涉及可用于治疗EP4介导的疾病或病症（例如急性和慢性疼痛，骨关节炎，类风湿性关节炎和癌症）的前列腺素E型受体拮抗剂的喹啉衍生物。 衍生物具有式（I）的以下结构：其中A和B表示氮原子或CH基团，条件是它们不能同时为CH，Q可以表示氮或碳原子，Y和Z 是氮原子，N（O）基或C（R5）基团。 还包括包含式（I）的衍生物的药物组合物。