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16 条记录 (耗时 0.035 秒)

    Quinoline derivatives as ep4 antagonists
    1.
    发明申请
    Quinoline derivatives as ep4 antagonists 有权
    喹啉衍生物作为ep4拮抗剂

    公开(公告)号：US20090099226A1

    公开(公告)日：2009-04-16

    申请号：US11920275

    申请日：2006-05-15

    申请人： Michel Belley ,  Jason Burch ,  John Colucci ,  Julie Farand ,  Mario Girard ,  Yongxin Han

    发明人： Michel Belley ,  Jason Burch ,  John Colucci ,  Julie Farand ,  Mario Girard ,  Yongxin Han

    IPC分类号： A61K31/437 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention is directed to quinoline derivatives as prostaglandin E type receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. The derivatives have the following structure of formula (I): wherein A and B represents either a nitrogen atom or a CH group with the proviso that they cannot both simultaneously be CH, Q can represent a nitrogen or a carbon atom, and Y and Z are either a nitrogen atom, a N(O) group or a C(R5) group. Pharmaceutical compositions comprising the derivatives of formula (I) are also included.

    摘要翻译： 本发明涉及可用于治疗EP4介导的疾病或病症（例如急性和慢性疼痛，骨关节炎，类风湿性关节炎和癌症）的前列腺素E型受体拮抗剂的喹啉衍生物。 衍生物具有式（I）的以下结构：其中A和B表示氮原子或CH基团，条件是它们不能同时为CH，Q可以表示氮或碳原子，Y和Z 是氮原子，N（O）基或C（R5）基团。 还包括包含式（I）的衍生物的药物组合物。

    Quinoline derivatives as EP4 antagonists
    2.
    发明授权
    Quinoline derivatives as EP4 antagonists 有权
    喹啉衍生物作为EP4拮抗剂

    公开(公告)号：US08013159B2

    公开(公告)日：2011-09-06

    申请号：US11920275

    申请日：2006-05-15

    申请人： Michel Belley ,  Jason Burch ,  John Colucci ,  Julie Farand ,  Mario Girard ,  Yongxin Han

    发明人： Michel Belley ,  Jason Burch ,  John Colucci ,  Julie Farand ,  Mario Girard ,  Yongxin Han

    IPC分类号： C07D471/00

    CPC分类号： C07D471/04

    摘要： The invention is directed to quinoline derivatives as prostaglandin E type receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis and cancer. The derivatives have the following structure of formula (I): wherein A and B represents either a nitrogen atom or a CH group with the proviso that they cannot both simultaneously be CH, Q can represent a nitrogen or a carbon atom, and Y and Z are either a nitrogen atom, a N(O) group or a C(R5) group. Pharmaceutical compositions comprising the derivatives of formula (I) are also included.

    摘要翻译： 本发明涉及可用于治疗EP4介导的疾病或病症（例如急性和慢性疼痛，骨关节炎，类风湿性关节炎和癌症）的前列腺素E型受体拮抗剂的喹啉衍生物。 衍生物具有式（I）的以下结构：其中A和B表示氮原子或CH基团，条件是它们不能同时为CH，Q可以表示氮或碳原子，Y和Z 是氮原子，N（O）基或C（R5）基团。 还包括包含式（I）的衍生物的药物组合物。

    Bicycle rear suspension
    8.
    发明授权
    Bicycle rear suspension 失效
    自行车后悬挂

    公开(公告)号：US06450520B1

    公开(公告)日：2002-09-17

    申请号：US09457314

    申请日：1999-12-09

    申请人： Mario Girard

    发明人： Mario Girard

    IPC分类号： B62K2528

    CPC分类号： B62K25/286 ,  B60G2202/116 ,  B60G2300/12 ,  B62K2025/041

    摘要： A rear suspension (10,64) for mountain bikes comprises a rigid link (46,98) pivotally mounted at opposed ends thereof to a lower rear portion of a main bicycle frame (14,74,96) and at a lower front portion of a bicycle swingarm (16,92). The rigid link (46,98) allows for relative displacements between the main bicycle frame (14,74,96) and the bicycle swingarm (16,92) along two degrees of freedom and, more particularly, for displacements in an area defined by the position of the two pivots (P1,P2) with respect to a rear wheel axle (WA), by the spacing between the two pivots (P1,P2) and also by the possible deformation of a spring (48,66) provided between the main frame (14,74,96) and the swingarm (16,92). A leaf spring (48,66) may be used within a shock absorber system which also includes a damper in order to limit relative displacements between the main frame (14,74,96) and the swingarm (16,92) upon impact of the rear wheel with an obstacle.

    摘要翻译： 用于山地自行车的后悬架（10,64）包括刚性连杆（46,98），所述刚性连杆枢转地安装在主自行车车架（14,74,96）的下后部的相对端处，并且在 自行车摇臂（16,92）。 刚性连杆（46,98）允许沿着两个自由度在主自行车车架（14,74,96）和自行车摇臂（16,92）之间的相对位移，更具体地说，用于在由 两个枢轴（P1，P2）相对于后轮轴（WA）的位置由两个枢轴（P1，P2）之间的间隔以及由弹簧（48,66）之间可能的变形而设置在 主框架（14,74,96）和摆臂（16,92）。 一个弹簧（48,66）可以用在减震器系统内，该减震器系统还包括阻尼器，以便在主框架（14,74,96）和摆臂（16,92）的冲击之后限制主框架 后轮有障碍物。