公开(公告)号：US08323701B2

公开(公告)日：2012-12-04

申请号：US12428908

申请日：2009-04-23

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。

公开(公告)号：US20130197665A1

公开(公告)日：2013-08-01

申请号：US13765640

申请日：2013-02-12

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K35/50 ,  A61L27/36

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

公开(公告)号：US08372438B2

公开(公告)日：2013-02-12

申请号：US13569138

申请日：2012-08-07

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。

公开(公告)号：US20120294908A1

公开(公告)日：2012-11-22

申请号：US13569134

申请日：2012-08-07

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K9/00 ,  A61K35/12

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

公开(公告)号：US20100104539A1

公开(公告)日：2010-04-29

申请号：US12428908

申请日：2009-04-23

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61F2/02 ,  A61K38/18 ,  A61K35/12 ,  C12N11/00 ,  A61P41/00

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。

公开(公告)号：US08372439B2

公开(公告)日：2013-02-12

申请号：US13569140

申请日：2012-08-07

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。

公开(公告)号：US08357403B2

公开(公告)日：2013-01-22

申请号：US12206508

申请日：2008-09-08

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

公开(公告)号：US20120294910A1

公开(公告)日：2012-11-22

申请号：US13569140

申请日：2012-08-07

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K9/00 ,  A61K35/12

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。

公开(公告)号：US08642092B2

公开(公告)日：2014-02-04

申请号：US13861305

申请日：2013-04-11

申请人： John Daniel ,  Randall Spencer ,  John Russo ,  Robert Tofe

发明人： John Daniel ,  Randall Spencer ,  John Russo ,  Robert Tofe

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

公开(公告)号：US08409626B2

公开(公告)日：2013-04-02

申请号：US13569134

申请日：2012-08-07

申请人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

发明人： John Daniel ,  Robert Tofe ,  Randall Spencer ,  John Russo

IPC分类号： A61K35/50

CPC分类号： A61K35/28 ,  A61F2/02 ,  A61F2210/00 ,  A61F2230/00 ,  A61K9/7007 ,  A61K35/19 ,  A61K35/33 ,  A61K35/50 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3834 ,  A61L27/56 ,  A61L2430/34 ,  A61L2430/40 ,  Y10T156/10 ,  Y10T156/1039

摘要： Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.

摘要翻译： 这里描述的是来自胎盘的组织移植物。 移植物由至少一层羊膜组织组成，其中已经基本上去除了上皮层，以便将基底层暴露于宿主细胞。 通过去除上皮层，来自宿主的细胞可以更容易地与位于基底膜顶部和内部的细胞粘附生物活性因子相互作用。 本文还描述了用于制造和使用组织移植物的方法。 羊膜组织的层粘连蛋白结构与天然人体组织例如口腔粘膜组织几乎相同。 这包括高水平的层粘连蛋白-5，表现为结合牙龈上皮细胞的细胞粘附生物活性因子，其遍及基底膜的上部。