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公开(公告)号：US06699193B2
公开(公告)日：2004-03-02
申请号：US09966366
申请日：2001-10-01
IPC分类号： A61B802
CPC分类号： A61B5/02007 , A61B5/4076 , A61B5/411 , A61B5/7264 , A61B8/06 , A61B8/56 , G01S7/52036 , G01S15/8915 , G01S15/8979 , G06F19/00 , G06Q10/10 , G06Q50/22
摘要： The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined manner. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. The present invention further provides an expert system for achieving the above.
摘要翻译： 本发明一般涉及用于评估血管中的血流量，用于评估血管健康，进行临床试验，筛选用于不良反应的治疗干预的系统和方法，以及用于评估危险因素，治疗和物质（包括治疗）的影响 物质，血管，特别是脑血管，都是通过测量一个或多个血管中的血液流动的各种参数而实现的，并以确定的方式分析结果。 血流相关参数包括平均流速，收缩期加速度和搏动指数。 通过测量和分析这些参数，可以确定特定血管，多个血管和个体的血管健康。 这样的测量还可以确定物质是否对血管健康具有有害或有利的作用。 本发明还提供了一种用于实现上述的专家系统。
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公开(公告)号：US06692443B2
公开(公告)日：2004-02-17
申请号：US09966360
申请日：2001-10-01
IPC分类号： A61B502
CPC分类号： A61B5/02007 , A61B5/4076 , A61B5/411 , A61B5/7264 , A61B8/06 , A61B8/56 , G01S7/52036 , G01S15/8915 , G01S15/8979 , G06F19/00 , G06Q10/10 , G06Q50/22
摘要： The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. In one of many embodiments, the present invention further provides an expert system for achieving the above.
摘要翻译： 本发明一般涉及用于评估血管中的血流量，用于评估血管健康，进行临床试验，筛选用于不良反应的治疗干预的系统和方法，以及用于评估危险因素，治疗和物质（包括治疗）的影响 物质，血管，特别是脑血管，都是通过测量一个或多个血管中的血液流动的各种参数而实现的，并在确定的物质中分析结果。 血流相关参数包括平均流速，收缩期加速度和搏动指数。 通过测量和分析这些参数，可以确定特定血管，多个血管和个体的血管健康。 这样的测量还可以确定物质是否对血管健康具有有害或有利的作用。 在许多实施例中的一个实施例中，本发明还提供了一种用于实现上述的专家系统。
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公开(公告)号：US06656122B2
公开(公告)日：2003-12-02
申请号：US09966367
申请日：2001-10-01
IPC分类号： A61B802
CPC分类号： A61B5/02007 , A61B5/4076 , A61B5/411 , A61B5/7264 , A61B8/06 , A61B8/56 , G01S7/52036 , G01S15/8915 , G01S15/8979 , G06F19/00 , G06Q10/10 , G06Q50/22
摘要： The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. The present invention further provides an expert system for achieving the above.
摘要翻译： 本发明一般涉及用于评估血管中的血流量，用于评估血管健康，进行临床试验，筛选用于不良反应的治疗干预的系统和方法，以及用于评估危险因素，治疗和物质（包括治疗）的影响 物质，血管，特别是脑血管，都是通过测量一个或多个血管中的血液流动的各种参数而实现的，并在确定的物质中分析结果。 血流相关参数包括平均流速，收缩期加速度和搏动指数。 通过测量和分析这些参数，可以确定特定血管，多个血管和个体的血管健康。 这样的测量还可以确定物质是否对血管健康具有有害或有利的作用。 本发明还提供了一种用于实现上述的专家系统。
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公开(公告)号：US06740038B2
公开(公告)日：2004-05-25
申请号：US09966359
申请日：2001-10-01
IPC分类号： A61B812
CPC分类号： A61B5/02007 , A61B5/4076 , A61B5/411 , A61B5/7264 , A61B8/06 , A61B8/56 , G01S7/52036 , G01S15/8915 , G01S15/8979 , G06F19/00 , G06Q10/10 , G06Q50/22
摘要： The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. In one of many embodiments, the present invention further provides an expert system for achieving the above.
摘要翻译： 本发明一般涉及用于评估血管中的血流量，用于评估血管健康，进行临床试验，筛选用于不良反应的治疗干预的系统和方法，以及用于评估危险因素，治疗和物质（包括治疗）的影响 物质，血管，特别是脑血管，都是通过测量一个或多个血管中的血液流动的各种参数而实现的，并在确定的物质中分析结果。 血流相关参数包括平均流速，收缩期加速度和搏动指数。 通过测量和分析这些参数，可以确定特定血管，多个血管和个体的血管健康。 这样的测量还可以确定物质是否对血管健康具有有害或有利的作用。 在许多实施例中的一个实施例中，本发明还提供了一种用于实现上述的专家系统。
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公开(公告)号：US06723051B2
公开(公告)日：2004-04-20
申请号：US09966368
申请日：2001-10-01
IPC分类号： A61B802
CPC分类号： A61B5/02007 , A61B5/4076 , A61B5/411 , A61B5/7264 , A61B8/06 , A61B8/56 , G01S7/52036 , G01S15/8915 , G01S15/8979 , G06F19/00 , G06Q10/10 , G06Q50/22
摘要： The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined manner. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. The present invention further provides an expert system for achieving the above.
摘要翻译： 本发明一般涉及用于评估血管中的血流量，用于评估血管健康，进行临床试验，筛选用于不良反应的治疗干预的系统和方法，以及用于评估危险因素，治疗和物质（包括治疗）的影响 物质，血管，特别是脑血管，都是通过测量一个或多个血管中的血液流动的各种参数而实现的，并以确定的方式分析结果。 血流相关参数包括平均流速，收缩期加速度和搏动指数。 通过测量和分析这些参数，可以确定特定血管，多个血管和个体的血管健康。 这样的测量还可以确定物质是否对血管健康具有有害或有利的作用。 本发明还提供了一种用于实现上述的专家系统。
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公开(公告)号：US07104958B2
公开(公告)日：2006-09-12
申请号：US10442194
申请日：2003-05-21
IPC分类号： A61B8/02
CPC分类号： A61B5/02007 , A61B5/0002 , A61B5/031 , A61B5/4088 , A61B5/411 , A61B5/7275 , A61B8/06 , A61B8/0808 , A61B8/56 , G01S15/8979 , G06F19/00
摘要： The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual's overall vascular health. The invention can track the onset, progression and treatment efficacy in an individual experiencing increased intracranial pressure, or can help identify underlying vulnerabilities of the vascular system to normal pressures, associated with and manifested as hydrocphalus or dementia.
摘要翻译： 本发明涉及用于评估单个或多个血管和节段中的血流的系统和方法，用于评估血管健康，进行临床试验，筛选治疗干预效果，评估风险因素，评估颅内压和分析结果 以定义的方式。 本发明能够直接监测血管，特别是脑血管系统的治疗，物质和装置。 相关血流参数包括平均流速，收缩期加速度和搏动指数。 这些参数的测量和分析以及其他参数提供了有关个体和多个血管的血管健康状况的细节，以及对个体血管总体健康状况的全面分析。 本发明可以跟踪经历颅内压增加的个体的发作，进展和治疗功效，或者可以帮助将血管系统的潜在的脆弱性识别为与肝硬化或痴呆相关并表现为正常压力的正常压力。
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7.发明申请Systems and methods for using dynamic vascular assessment to improve vascular stent placement, application, design and marketing 失效使用动态血管评估改进血管支架置入，应用，设计和营销的系统和方法公开(公告)号：US20050038342A1
公开(公告)日：2005-02-17
申请号：US10755208
申请日：2004-01-12
申请人： B. Mozayeni , Kevin Crutchfield , Simon Fitall
发明人： B. Mozayeni , Kevin Crutchfield , Simon Fitall
CPC分类号： A61B8/06 , A61B5/02007 , A61B5/411 , A61B5/7264 , A61B8/0808 , A61B8/56 , G01S7/52036 , G01S15/8915 , G01S15/8979 , G06Q10/10
摘要： The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual's overall vascular health. The invention is applicable as both a system and method for monitoring and improving the design, performance, marketing and use of vascular stents. In particular, the invention enables DVA-assisted stenting procedures, including both pre-operative and post-operative management.
摘要翻译： 本发明涉及用于评估单个或多个血管和节段中的血流的系统和方法，用于评估血管健康，进行临床试验，筛选治疗干预效果，评估风险因素，评估颅内压和分析结果 以定义的方式。 本发明能够直接监测血管，特别是脑血管系统的治疗，物质和装置。 相关血流参数包括平均流速，收缩期加速度和搏动指数。 这些参数的测量和分析以及其他参数提供了有关个体和多个血管的血管健康状况的细节，以及对个体血管总体健康状况的全面分析。 本发明既可用于监测和改进血管支架的设计，性能，营销和使用的系统和方法。 特别地，本发明使得能够进行DVA辅助的支架术程序，包括手术前和手术后管理。
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公开(公告)号：US20050171432A1
公开(公告)日：2005-08-04
申请号：US10948218
申请日：2004-09-24
申请人： Kevin Crutchfield , B. Mozayeni , Robert Beckman , Luke Beckman
发明人： Kevin Crutchfield , B. Mozayeni , Robert Beckman , Luke Beckman
CPC分类号： A61B8/06 , A61B5/4818 , A61B8/0808
摘要： The present invention comprises methods for detecting, assessing, diagnosing, and pre-diagnosing sleep apnea, and for assessing the efficacy of a treatment for sleep apnea. Methods for the detection, assessment, diagnosis and pre-diagnosis (screening) of sleep apnea and the assessment of a treatment for sleep apnea according to the present invention may be performed in the absence of a sleep study. The patients subject to these methods may remain awake during their performance. The invention may be applied to other vascular conditions besides sleep apnea, wherein the sleep apnea methods described herein are example methods for the application of the present invention to the detection, assessment, diagnosis and pre-diagnosis (screening) of other vascular conditions.
摘要翻译： 本发明包括用于检测，评估，诊断和预诊断睡眠呼吸暂停的方法，以及用于评估治疗睡眠呼吸暂停的功效的方法。 根据本发明的睡眠呼吸暂停的检测，评估，诊断和预诊断（筛选）和睡眠呼吸暂停治疗的评估方法可以在没有睡眠研究的情况下进行。 患有这些方法的患者在执行过程中可能会保持清醒。 本发明可以应用于除了睡眠呼吸暂停之外的其它血管疾病，其中本文所述的睡眠呼吸暂停方法是将本发明应用于其它血管病症的检测，评估，诊断和预诊断（筛选）的示例性方法。
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9.发明申请公开(公告)号：US20070016046A1
公开(公告)日：2007-01-18
申请号：US11387049
申请日：2006-03-23
申请人： B. Mozayeni , Kevin Crutchfield
发明人： B. Mozayeni , Kevin Crutchfield
IPC分类号： A61B8/00
CPC分类号： A61B8/06 , A61B8/0808
摘要： The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual's overall vascular health. The invention can track the onset, progression and treatment efficacy in an individual experiencing increased intracranial pressure, or can help identify underlying vulnerabilities of the vascular system to normal pressures, associated with and manifested as hydrocphalus or dementia.
摘要翻译： 本发明涉及用于评估单个或多个血管和节段中的血流的系统和方法，用于评估血管健康，进行临床试验，筛选治疗干预效果，评估风险因素，评估颅内压和分析结果 以定义的方式。 本发明能够直接监测血管，特别是脑血管系统的治疗，物质和装置。 相关血流参数包括平均流速，收缩期加速度和搏动指数。 这些参数的测量和分析以及其他参数提供了有关个体和多个血管的血管健康状况的细节，以及对个体血管总体健康状况的全面分析。 本发明可以追踪经历颅内压升高的个体的发作，进展和治疗效果，或者可以帮助将血管系统的潜在的脆弱性识别为与肝硬化或痴呆相关并表现为正常压力的正常压力。
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