利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.027 秒)

    Modulation of the activity and differentiation of cells expressing the osteoclast-associated receptor
    3.
    发明授权
    Modulation of the activity and differentiation of cells expressing the osteoclast-associated receptor 失效
    调节表达破骨细胞相关受体的细胞的活性和分化

    公开(公告)号：US08642728B2

    公开(公告)日：2014-02-04

    申请号：US13122637

    申请日：2009-10-06

    申请人： John Trowsdale ,  Alexander Barrow ,  Richard Farndale

    发明人： John Trowsdale ,  Alexander Barrow ,  Richard Farndale

    IPC分类号： A61K38/39 ,  A61K38/17 ,  C07K14/78

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/78

    摘要： This invention relates to the finding that collagen peptides bind to the osteoclast-associated receptor (OSCAR) and stimulate the activation and/or differentiation of OSCAR expressing cells, such as osteoclasts and osteoclast precursor cells. Collagen peptides are described which may be useful in the modulation of the differentiation and/or activation of OSCAR expressing cells, for example in the treatment of bone defects and disorders characterized by altered differentiation and/or activation of OS-CAR expressing cells.

    摘要翻译： 本发明涉及胶原肽与破骨细胞相关受体（OSCAR）结合并刺激表达OSCAR的细胞如破骨细胞和破骨细胞前体细胞的活化和/或分化的发现。 描述了胶原肽，其可用于调节表达OSCAR的细胞的分化和/或活化，例如在治疗由OSCAR表达细胞的分化和/或激活的改变而表征的骨缺损和病症的治疗中。

    Proteins Ligands For Nkg2d And Ul16 Receptors And Uses Thereof
    5.
    发明申请
    Proteins Ligands For Nkg2d And Ul16 Receptors And Uses Thereof 审中-公开
    蛋白质配体Nkg2d和Ul16受体及其用途

    公开(公告)号：US20080038248A1

    公开(公告)日：2008-02-14

    申请号：US10589851

    申请日：2005-02-17

    申请人： John Trowsdale ,  Robert Eagle ,  Louise Bacon

    发明人： John Trowsdale ,  Robert Eagle ,  Louise Bacon

    IPC分类号： A61K39/395 ,  A61K31/711 ,  A61P35/00 ,  C07H21/04 ,  C07K16/00 ,  C12N15/63 ,  G01N33/53 ,  G01N33/50 ,  C12N1/21 ,  C07K14/00 ,  A61P37/00 ,  A61K38/16

    CPC分类号： C07K14/705

    摘要： A novel member of the RAET1/ULBP family of proteins (RAET1G) is identified and characterised and shown to bind the UL16 and NKG2D receptors with high affinity. RAET1G exhibits restricted expression in normal tissues but exhibits high levels of expression in tumours and may be differentially spliced in cancer cells to produce a soluble protein. RAET1G is also up-regulated in inflammatory diseases such as coeliac disease. RAET1G may be used as a novel marker for disease conditions including cancer conditions and inflammatory diseases.

    摘要翻译： RAET1 / ULBP蛋白家族（RAET1G）的新成员被鉴定和表征，并显示以高亲和力结合UL16和NKG2D受体。 RAET1G在正常组织中表现出限制性表达，但在肿瘤中表现出高水平的表达，并且可能在癌细胞中差异性剪接以产生可溶性蛋白质。 RAET1G也在炎症性疾病如乳糜泻中上调。 RAET1G可用作疾病状况的新型标志物，包括癌症和炎性疾病。