公开(公告)号：US09220522B2

公开(公告)日：2015-12-29

申请号：US12182370

申请日：2008-07-30

申请人： John Fulkerson ,  David A. Ferrera

发明人： John Fulkerson ,  David A. Ferrera

IPC分类号： A61B17/22 ,  A61B17/24 ,  A61B17/221 ,  A61F2/01 ,  A61M25/09

CPC分类号： A61B17/221 ,  A61B2017/22039 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61M25/09 ,  A61M25/09025

摘要： Systems for treatment of ischemic stroke can include tethered baskets. A basket can be tethered to a pusher or elongate member. A temporary reperfusion device or temporary capture device also can be tethered to the pusher or elongate member.

摘要翻译： 用于治疗缺血性卒中的系统可包括系绳筐。 篮子可以束缚到推动器或细长构件。 临时再灌注装置或临时捕获装置也可以连接到推动器或细长构件。

公开(公告)号：US09198687B2

公开(公告)日：2015-12-01

申请号：US12123390

申请日：2008-05-19

申请人： John Fulkerson ,  David A. Ferrera ,  Andrew Cragg

发明人： John Fulkerson ,  David A. Ferrera ,  Andrew Cragg

IPC分类号： A61F2/06 ,  A61B17/3207 ,  A61B17/221 ,  A61F2/82 ,  A61M29/02 ,  A61B17/00 ,  A61B17/22 ,  A61F2/01 ,  A61M25/10

CPC分类号： A61B17/3207 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00845 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2017/22082 ,  A61F2/013 ,  A61F2/82 ,  A61F2250/0059 ,  A61M29/02 ,  A61M2025/1095 ,  A61M2025/1097

摘要： An acute stroke recanalization system and processes include catheter-based improved reconstrainable or tethered neurological devices which are deliverable through highly constricted and tortuous vessels, crossing the zone associated with subject thrombi/emboli, where deployment impacts, addresses or bridges the embolus, compacting the same into luminal walls which enables perfusion and lysis of the embolus, while the improved neurological medical device itself remains contiguous with the delivery system acting as a filter, basket or stand alone stenting mechanism, depending on the status of the embolus and other therapeutic aspects of the treatment being offered for consideration.

摘要翻译： 急性中风再通系统和过程包括基于导管的改善的可重建或系留的神经系统装置，其可通过高度收缩和曲折的血管交付，穿过与受试者血栓/栓塞相关的区域，其中部署影响，解决或桥接栓塞，压制相同 进入能够灌注和溶解栓塞的腔壁，而改进的神经医学装置本身与作为过滤器，篮子或独立支架机构的输送系统保持连续，这取决于栓塞的状态和其他治疗方面 治疗被提供考虑。

公开(公告)号：US08945172B2

公开(公告)日：2015-02-03

申请号：US13341186

申请日：2011-12-30

申请人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

发明人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

IPC分类号： A61M29/00 ,  A61F2/01 ,  A61B17/221 ,  A61M25/09 ,  A61B17/3207 ,  A61B17/22

CPC分类号： A61B17/221 ,  A61B17/320783 ,  A61B2017/22039 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61F2/013 ,  A61F2002/016 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/0097 ,  A61M25/09 ,  A61M25/09025

摘要： Devices for restoring blood flow to facilitate lysis of clots and/or enable capture of clots are disclosed. The devices can be configured to be disposed within a lumen of a microcatheter that is inserted within neurovasculature above a carotid siphon to a location of a clot. The devices can include an elongate pusher member and a self-expandable capturing member coupled to a distal end of the elongate pusher member. The capturing member can comprise a generally cylindrical body having an cell structure that is configured to compress the clot against an inner wall of the neurovasculature and capture the clot at least partially on a surface of the generally cylindrical body upon deployment of the capturing member from the microcatheter, thereby restoring blood flow to the neurovasculature downstream of the clot.

摘要翻译： 公开了用于恢复血液流动以促进凝块裂解和/或能够捕获凝块的装置。 所述装置可以被配置为设置在微导管的内腔中，所述微导管插入到颈动脉虹吸管以上的神经血管内至凝块的位置。 该装置可以包括细长的推动器构件和联接到细长推动构件的远端的自扩张捕获构件。 捕获构件可以包括大致圆柱形的主体，其具有细胞结构，所述细胞结构被配置为相对于神经血管系统的内壁压缩凝块，并且在从所述捕获构件展开时至少部分地将所述凝块至少部分地捕获在所述大致圆柱形主体的表面上 微导管，从而恢复到凝块下游神经血管的血流。

公开(公告)号：US08088140B2

公开(公告)日：2012-01-03

申请号：US12475389

申请日：2009-05-29

申请人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

发明人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

IPC分类号： A61M29/00

CPC分类号： A61B17/221 ,  A61B17/320783 ,  A61B2017/22039 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61F2/013 ,  A61F2002/016 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/0097 ,  A61M25/09 ,  A61M25/09025

摘要： Methods for restoring blood flow in occluded blood vessels are disclosed. The methods can include accessing an artery with a catheter system and locating an occluded zone within the artery caused by an embolus. The catheter system can include a microcatheter and a blood flow restoration device or an embolus removal device having a self-expandable member configured to be delivered through the microcatheter in a compressed configuration and to be deployed to an expanded configuration upon retraction of the microcatheter. The methods can include deploying the self-expandable member at the location of the occluded zone such that the self-expandable member engages and captures the embolus upon deployment of the self-expandable member and removing the embolus by withdrawing the blood flow restoration device or the embolus removal device.

摘要翻译： 公开了恢复闭塞血管中血流的方法。 该方法可以包括使用导管系统进入动脉并且定位由栓塞引起的动脉内的闭塞区域。 导管系统可以包括微导管和血液流动恢复装置或具有自膨胀构件的栓塞移除装置，所述自扩张构件构造成以压缩构型输送通过微导管，并且在缩回微导管时被部署到扩张构型。 所述方法可以包括在封闭区域的位置处部署自扩张构件，使得自展开构件在展开自扩张构件时接合并捕获栓塞，并且通过抽出血流恢复装置或 栓塞装置。

公开(公告)号：US20100318097A1

公开(公告)日：2010-12-16

申请号：US12835497

申请日：2010-07-13

申请人： David A. Ferrera ,  John Fulkerson ,  Andrew Cragg

发明人： David A. Ferrera ,  John Fulkerson ,  Andrew Cragg

IPC分类号： A61B17/221

CPC分类号： A61B17/3207 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00845 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2017/22082 ,  A61F2/013 ,  A61F2/82 ,  A61F2250/0059 ,  A61M29/02 ,  A61M2025/1095 ,  A61M2025/1097

摘要： An acute stroke recanalization system and processes include catheter-based improved reconstrainable or tethered neurological devices which are deliverable through highly constricted and tortuous vessels, crossing the zone associated with subject thrombi/emboli, where deployment impacts, addresses or bridges the embolus, compacting the same into luminal walls which enables perfusion and lysis of the embolus, while the improved neurological medical device itself remains contiguous with the delivery system acting as a filter, basket or stand alone stenting mechanism, depending on the status of the embolus and other therapeutic aspects of the treatment being offered for consideration.

摘要翻译： 急性中风再通系统和过程包括基于导管的改善的可重建或系留的神经系统装置，其可通过高度收缩和曲折的血管交付，穿过与受试者血栓/栓塞相关的区域，其中部署影响，解决或桥接栓塞，压制相同 进入能够灌注和溶解栓塞的腔壁，而改进的神经医学装置本身与作为过滤器，篮子或独立支架机构的输送系统保持连续，这取决于栓塞的状态和其他治疗方面 治疗被提供考虑。

公开(公告)号：US20090125053A1

公开(公告)日：2009-05-14

申请号：US12136737

申请日：2008-06-10

申请人： David A. Ferrera ,  John Fulkerson

发明人： David A. Ferrera ,  John Fulkerson

IPC分类号： A61M29/02

CPC分类号： A61B17/12022 ,  A61B17/12118 ,  A61B17/1214 ,  A61B2017/1205 ,  A61F2/90 ,  A61F2002/823 ,  A61F2250/0059

摘要： Devices, methods and systems facilitate and enable vessel wall treatment, particularly at the neck of an aneurysm. A tethered cage-like structure functions in conjunction with supplemental therapies such as a vaso-occlusive coil delivering microcatheter system and/or pharmaceutical delivery, among other things, by stabilizing vessel walls and providing tethered cage-like therapeutic support for treating aneurysms, temporarily or on an implantable basis.

摘要翻译： 装置，方法和系统便于和启用血管壁治疗，特别是在动脉瘤的颈部。 拴系的笼状结构与补充疗法结合起来，例如通过稳定血管壁并提供用于治疗动脉瘤的拴系的笼状治疗支持物来暂时或临时地治疗动脉瘤，所述补充疗法例如提供微导管系统和/或药物递送的血管闭塞线圈 在可植入的基础上。

公开(公告)号：US20120116443A1

公开(公告)日：2012-05-10

申请号：US13341186

申请日：2011-12-30

申请人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

发明人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

IPC分类号： A61B17/22

CPC分类号： A61B17/221 ,  A61B17/320783 ,  A61B2017/22039 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61F2/013 ,  A61F2002/016 ,  A61F2230/0069 ,  A61F2230/0076 ,  A61F2230/0097 ,  A61M25/09 ,  A61M25/09025

摘要： Devices for restoring blood flow to facilitate lysis of clots and/or enable capture of clots are disclosed. The devices can be configured to be disposed within a lumen of a microcatheter that is inserted within neurovasculature above a carotid siphon to a location of a clot. The devices can include an elongate pusher member and a self-expandable capturing member coupled to a distal end of the elongate pusher member. The capturing member can comprise a generally cylindrical body having an cell structure that is configured to compress the clot against an inner wall of the neurovasculature and capture the clot at least partially on a surface of the generally cylindrical body upon deployment of the capturing member from the microcatheter, thereby restoring blood flow to the neurovasculature downstream of the clot.

摘要翻译： 公开了用于恢复血液流动以促进凝块裂解和/或能够捕获凝块的装置。 所述装置可以被配置为设置在微导管的内腔中，所述微导管插入到颈动脉虹吸管以上的神经血管内至凝块的位置。 该装置可以包括细长的推动器构件和联接到细长推动构件的远端的自扩张捕获构件。 捕获构件可以包括大致圆柱形的主体，其具有细胞结构，所述细胞结构被配置为相对于神经血管系统的内壁压缩凝块，并且在从所述捕获构件展开时至少部分地将所述凝块至少部分地捕获在所述大致圆柱形主体的表面上 微导管，从而恢复到凝块下游神经血管的血流。

公开(公告)号：US08070791B2

公开(公告)日：2011-12-06

申请号：US12981363

申请日：2010-12-29

申请人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

发明人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

IPC分类号： A61F2/06 ,  A61B17/22 ,  A61D1/02 ,  A61M29/00

CPC分类号： A61F2/82 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00309 ,  A61B2017/00867 ,  A61B2017/22001 ,  A61B2017/22034 ,  A61B2017/22039 ,  A61B2017/22079 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/2215 ,  A61B2017/32096 ,  A61B2090/3966 ,  A61F2/91 ,  A61F2/915 ,  A61M25/0074 ,  A61M2025/0042

摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.

摘要翻译： 用于治疗急性缺血性卒中的系统，方法和装置，其为血栓阻塞的血管提供即时血流恢复，并且在重新建立血流之后，解决凝块本身。 立即血流恢复有利地可以促进凝块的自然裂解，并且还可以减少或消除由于凝块断裂引起的远端栓塞的担忧。 本发明的几个实施方案基于凝块的性质提供逐步或模块化的治疗。 例如，逐步治疗可以包括三步逐步治疗过程，其包括根据治疗的具体情况立即恢复血流，原位血块管理和/或血块去除。 原位血块管理可以包括例如裂解和浸渍。 逐步或模块化的治疗可以由一个或多个治疗装置的系统或试剂盒提供。

公开(公告)号：US20110238106A1

公开(公告)日：2011-09-29

申请号：US13151200

申请日：2011-06-01

申请人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

发明人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

IPC分类号： A61F2/01

CPC分类号： A61F2/82 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00309 ,  A61B2017/00867 ,  A61B2017/22001 ,  A61B2017/22034 ,  A61B2017/22039 ,  A61B2017/22079 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/2215 ,  A61B2017/32096 ,  A61B2090/3966 ,  A61F2/91 ,  A61F2/915 ,  A61M25/0074 ,  A61M2025/0042

摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.

公开(公告)号：US20110160763A1

公开(公告)日：2011-06-30

申请号：US12980039

申请日：2010-12-28

申请人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

发明人： David A. Ferrera ,  Andrew H. Cragg ,  John Fulkerson

IPC分类号： A61F2/01

CPC分类号： A61F2/82 ,  A61B17/12118 ,  A61B17/1214 ,  A61B17/221 ,  A61B17/320725 ,  A61B2017/00309 ,  A61B2017/00867 ,  A61B2017/22001 ,  A61B2017/22034 ,  A61B2017/22039 ,  A61B2017/22079 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/2215 ,  A61B2017/32096 ,  A61B2090/3966 ,  A61F2/91 ,  A61F2/915 ,  A61M25/0074 ,  A61M2025/0042

摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.

摘要翻译： 用于治疗急性缺血性卒中的系统，方法和装置，其为血栓阻塞的血管提供即时血流恢复，并且在重新建立血流之后，解决凝块本身。 立即血流恢复有利地可以促进凝块的自然裂解，并且还可以减少或消除由于凝块断裂引起的远端栓塞的担忧。 本发明的几个实施方案基于凝块的性质提供逐步或模块化的治疗。 例如，逐步治疗可以包括三步逐步治疗过程，其包括根据治疗的具体情况立即恢复血流，原位血块管理和/或血块去除。 原位血块管理可以包括例如裂解和浸渍。 逐步或模块化的治疗可以由一个或多个治疗装置的系统或试剂盒提供。