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    Minimally Invasive Monitoring Systems for Monitoring a Patient's Propensity for a Neurological Event
    2.
    发明申请
    Minimally Invasive Monitoring Systems for Monitoring a Patient's Propensity for a Neurological Event 审中-公开
    用于监测患者神经事件倾向的微创监测系统

    公开(公告)号：US20080027348A1

    公开(公告)日：2008-01-31

    申请号：US11766761

    申请日：2007-06-21

    申请人： John Harris ,  Kent Leyde ,  Jaideep Mavoori

    发明人： John Harris ,  Kent Leyde ,  Jaideep Mavoori

    IPC分类号： A61B5/0476

    CPC分类号： A61N1/37229 ,  A61B5/0031 ,  A61B5/0476 ,  A61B5/4094 ,  A61B2560/0214 ,  A61N1/36064

    摘要： The present invention provides systems and methods for ambulatory, long term monitoring of a physiological signal from a patient. At least a portion of the systems of the present invention may be implanted within the patient in a minimally invasive manner. In preferred embodiments, brain activity signals are sampled from the patient with an externally powered leadless implanted device and are transmitted to a handheld patient communication device for processing to estimate the patient's propensity for a seizure.

    摘要翻译： 本发明提供了用于从患者进行生理信号的长期监测的系统和方法。 本发明的系统的至少一部分可以以微创方式植入患者体内。 在优选实施例中，使用外部供电的无引入植入装置从患者对脑活动信号进行采样，并将其传送到手持式病人通信装置进行处理以估计患者癫痫发作倾向。

    Minimally Invasive Monitoring Methods
    3.
    发明申请
    Minimally Invasive Monitoring Methods 审中-公开
    微创监测方法

    公开(公告)号：US20080027347A1

    公开(公告)日：2008-01-31

    申请号：US11766751

    申请日：2007-06-21

    申请人： John Harris ,  Kent Leyde ,  Jaideep Mavoori

    发明人： John Harris ,  Kent Leyde ,  Jaideep Mavoori

    IPC分类号： A61B5/0476

    CPC分类号： A61N1/37229 ,  A61B5/0031 ,  A61B5/0476 ,  A61B5/4094 ,  A61B2560/0214 ,  A61N1/36064

    摘要： The present invention provides methods for minimally invasive, long term monitoring of a physiological signal (e.g., neural signals) from a patient. In preferred embodiments, neural signals are sampled from the patient with an externally powered, leadless implanted device and are transmitted to an external device for further processing.

    摘要翻译： 本发明提供了用于对来自患者的生理信号（例如，神经信号）的微创长期监测的方法。 在优选实施例中，使用外部供电的无引线植入装置从患者采集神经信号，并将其传输到外部装置以进一步处理。

    Minimally Invasive Monitoring Systems
    4.
    发明申请
    Minimally Invasive Monitoring Systems 审中-公开
    微创监测系统

    公开(公告)号：US20080027515A1

    公开(公告)日：2008-01-31

    申请号：US11766742

    申请日：2007-06-21

    申请人： John Harris ,  Kent Leyde ,  Jaideep Mavoori

    发明人： John Harris ,  Kent Leyde ,  Jaideep Mavoori

    IPC分类号： A61B5/0476 ,  A61B5/04

    CPC分类号： A61N1/37229 ,  A61B5/0031 ,  A61B5/0476 ,  A61B5/4094 ,  A61B2560/0214 ,  A61N1/36064

    摘要： The present invention provides systems and methods for ambulatory, long term monitoring of a physiological signal from a patient. At least a portion of the systems of the present invention may be implanted within the patient in a minimally invasive manner. In preferred embodiments, brain activity signals are sampled from the patient with an externally powered leadless implanted device and are transmitted to a handheld patient communication device for further processing.

    摘要翻译： 本发明提供了用于从患者进行生理信号的长期监测的系统和方法。 本发明的系统的至少一部分可以以微创方式植入患者体内。 在优选实施例中，使用外部供电的无引入植入装置从患者采集脑活动信号，并将其发送到手持式病人通信装置以进一步处理。

    Methods and Systems for Facilitating Clinical Trials
    5.
    发明申请
    Methods and Systems for Facilitating Clinical Trials 审中-公开
    促进临床试验的方法和系统

    公开(公告)号：US20080021341A1

    公开(公告)日：2008-01-24

    申请号：US11766756

    申请日：2007-06-21

    申请人： John Harris ,  Kent Leyde

    发明人： John Harris ,  Kent Leyde

    IPC分类号： A61B5/0476

    CPC分类号： A61N1/37229 ,  A61B5/0031 ,  A61B5/0476 ,  A61B5/4094 ,  A61B2560/0214 ,  A61N1/36064

    摘要： The present invention provides methods and systems for improving clinical trials of experimental therapies. The present invention uses minimally invasive, leadless implantable devices that facilitate long term monitoring of a physiological signal (e.g., neural signals) from a patient population which may provide an indication of the effect of the experimental therapy on the patient population. In preferred embodiments, neural signals are sampled from the patients in the patient population with an externally powered, leadless implanted device and are transmitted to an external device for further processing.

    摘要翻译： 本发明提供用于改善实验疗法的临床试验的方法和系统。 本发明使用促进长期监测来自患者群体的生理信号（例如，神经信号）的微创无引导植入式装置，其可以提供实验治疗对患者群体的影响的指示。 在优选实施例中，使用外部供电的无引线植入装置从患者群体中的患者采集神经信号，并将其传输到外部装置以进行进一步处理。

    Low Power Device With Variable Scheduling
    7.
    发明申请
    Low Power Device With Variable Scheduling 有权
    具有可变调度功能的低功率设备

    公开(公告)号：US20080161713A1

    公开(公告)日：2008-07-03

    申请号：US11616793

    申请日：2006-12-27

    申请人： Kent Leyde ,  John Harris

    发明人： Kent Leyde ,  John Harris

    IPC分类号： A61B5/0476

    CPC分类号： A61B5/0476 ,  A61B5/0006 ,  A61B5/4094 ,  A61B5/7264 ,  A61B2560/0209 ,  G06F19/00 ,  G16H40/63

    摘要： Medical device systems and methods for operating medical device systems conserve energy by efficiently managing computational demands of the systems. Signals from a subject are processed and analyzed and an estimate of a propensity for a subject to have a neurological event is determined. Based on the results of the analysis and the estimate, further analysis may be performed and the estimate may be refined. Succeeding cycles of signal measurement and analysis are scheduled depending on the results of the analysis and the estimate. The schedule may be varied temporally or with regard to the types and intensities of analyses performed.

    摘要翻译： 用于操作医疗设备系统的医疗设备系统和方法通过有效地管理系统的计算需求来节省能量。 来自受试者的信号被处理和分析，并且确定受试者具有神经系统事件的倾向的估计。 根据分析结果和估计结果，可以进一步分析，并且可以对估计进行改进。 信号测量和分析的成功周期取决于分析结果和估计。 时间表可以在时间上改变，或者关于所执行的分析的类型和强度。

    Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
    9.
    发明授权
    Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy 有权
    用于增强或影响神经刺激效率和/或功效的系统和方法

    公开(公告)号：US07483747B2

    公开(公告)日：2009-01-27

    申请号：US11182713

    申请日：2005-07-15

    申请人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    发明人： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

    IPC分类号： A61N1/00

    CPC分类号： H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

    摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

    摘要翻译： 公开了用于增强或影响神经刺激效率和/或功效的系统和方法。 在一个实施例中，系统和/或方法可以根据第一组刺激参数以及根据第二组刺激参数在第二时域上对第一时域的患者神经系统施加电磁刺激。 第一和第二时域可以是顺序的，同时的或嵌套的。 刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。 刺激可以在一个或多个周期性，非周期性（例如混沌）和/或伪随机方式中的亚阈值，阈值和/或超阈值水平下应用。 在一些实施例中，刺激可以包括具有对应于固有脑波频率的突发​​频率以及规则和/或变化的腹内刺激参数的突发模式。 在中等或显着的电源耗尽之前，可以施加具有至少足够的症状缓解的降低功耗的刺激信号。

    Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
    10.
    发明申请
    Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders 有权
    用于向患者推荐用于管理癫痫和其他神经障碍的适当动作的方法和系统

    公开(公告)号：US20070150024A1

    公开(公告)日：2007-06-28

    申请号：US11321897

    申请日：2005-12-28

    申请人： Kent Leyde ,  Daniel Dilorenzo

    发明人： Kent Leyde ,  Daniel Dilorenzo

    IPC分类号： A61N1/00

    CPC分类号： A61B5/4094 ,  A61B5/0476 ,  A61B5/048 ,  A61B5/7264 ,  A61B5/7275 ,  A61N1/36082 ,  A61N1/37247 ,  A61N1/37258 ,  G06F19/00

    摘要： The present invention provides methods and system for managing neurological disorders such as epilepsy. In one embodiment, the method comprises measuring one or more signals from a patient and processing the one or more signals to characterize a patient's propensity for a future seizure. The characterized propensity for the seizure is thereafter used to determine an appropriate action for managing or treating the predicted seizure; and a recommendation is communicated to the patient that is indicative of the appropriate action.

    摘要翻译： 本发明提供了用于治疗诸如癫痫的神经障碍的方法和系统。 在一个实施例中，该方法包括测量来自患者的一个或多个信号并处理一个或多个信号以表征患者将来发作的倾向。 其特征是缉获倾向之后用于确定管理或治疗预期癫痫发作的适当行动; 并且向患者传达指示适当动作的建议。