公开(公告)号：US20070219206A1

公开(公告)日：2007-09-20

申请号：US11744555

申请日：2007-05-04

申请人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Brian Stearns ,  Jeffrey Roppe ,  Bowei Wang ,  Yen Truong ,  Yiwei Li ,  Jasmine Zunic ,  Jeannie Arruda ,  Nicholas Stock ,  Mustapha Haddach ,  Thomas Seiders ,  Jill Scott

发明人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Brian Stearns ,  Jeffrey Roppe ,  Bowei Wang ,  Yen Truong ,  Yiwei Li ,  Jasmine Zunic ,  Jeannie Arruda ,  Nicholas Stock ,  Mustapha Haddach ,  Thomas Seiders ,  Jill Scott

IPC分类号： A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/498 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/4439 ,  A61K31/42 ,  A61K31/428 ,  A61K31/404 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

公开(公告)号：US20070105866A1

公开(公告)日：2007-05-10

申请号：US11553946

申请日：2006-10-27

申请人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Yiwei Li ,  Jasmine Zunic ,  Jeannie Arruda ,  Nicholas Stock ,  Brian Stearns ,  Mustapha Haddach ,  Jeffrey Roppe

发明人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Yiwei Li ,  Jasmine Zunic ,  Jeannie Arruda ,  Nicholas Stock ,  Brian Stearns ,  Mustapha Haddach ,  Jeffrey Roppe

IPC分类号： A61K31/501 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/427 ,  C07D417/02 ,  C07D403/02

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D403/10 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

公开(公告)号：US20070123522A1

公开(公告)日：2007-05-31

申请号：US11538762

申请日：2006-10-04

申请人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Jasmine Zunic ,  Nicholas Stock

发明人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Jasmine Zunic ,  Nicholas Stock

IPC分类号： A61K31/5415 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/4745 ,  A61K31/519 ,  C07D498/02 ,  C07D491/02 ,  C07D471/02

CPC分类号： C07D491/02 ,  C07D471/04 ,  C07D498/02

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

公开(公告)号：US20070179190A1

公开(公告)日：2007-08-02

申请号：US10591820

申请日：2005-03-07

申请人： William Hagmann ,  Linus Lin ,  Ping Liu ,  Richard Mumford ,  Thomas Reger ,  Nicholas Smith ,  Nicholas Stock ,  Jasmine Zunic

发明人： William Hagmann ,  Linus Lin ,  Ping Liu ,  Richard Mumford ,  Thomas Reger ,  Nicholas Smith ,  Nicholas Stock ,  Jasmine Zunic

IPC分类号： A61K31/44 ,  A01N43/40

CPC分类号： C07K5/06026 ,  C07D401/12 ,  C07D401/14

摘要： Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn's disease, multiple sclerosis, asthma, and rheumatoid arthritis.

摘要翻译： 式I的化合物是VLA-4的拮抗剂，因此可用于抑制或预防细胞粘附和细胞粘附介导的病症。 这些化合物可以配制成药物组合物，并且适用于治疗包括溃疡性结肠炎和克罗恩病，多发性硬化，哮喘和类风湿性关节炎的炎性肠病。

公开(公告)号：US07514409B2

公开(公告)日：2009-04-07

申请号：US10591820

申请日：2005-03-07

申请人： William K. Hagmann ,  Linus S. Lin ,  Ping Liu ,  Richard A. Mumford ,  Thomas S. Reger ,  Nicholas D. Smith ,  Nicholas S. Stock ,  Jasmine Zunic

发明人： William K. Hagmann ,  Linus S. Lin ,  Ping Liu ,  Richard A. Mumford ,  Thomas S. Reger ,  Nicholas D. Smith ,  Nicholas S. Stock ,  Jasmine Zunic

IPC分类号： A61K38/05

CPC分类号： C07K5/06026 ,  C07D401/12 ,  C07D401/14

摘要： Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn's disease, multiple sclerosis, asthma, and rheumatoid arthritis.

摘要翻译： 式I的化合物是VLA-4的拮抗剂，因此可用于抑制或预防细胞粘附和细胞粘附介导的病症。 这些化合物可以配制成药物组合物，并且适用于治疗包括溃疡性结肠炎和克罗恩病，多发性硬化，哮喘和类风湿性关节炎的炎性肠病。