-
1.发明申请Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics 审中-公开稳定的PSMA适应症及其作为前列腺癌治疗用途公开(公告)号：US20090105172A1
公开(公告)日：2009-04-23
申请号：US11885908
申请日：2006-03-07
申请人： John L. Diener , Paul Hatala , Jason R. Killough , Jess Wagner-Whyte , Charles Wilson , Shuhao Zhu
发明人： John L. Diener , Paul Hatala , Jason R. Killough , Jess Wagner-Whyte , Charles Wilson , Shuhao Zhu
IPC分类号： A61K31/7088 , C07H21/00 , C12Q1/68 , A61P43/00
CPC分类号： C12N15/115 , A61K47/549 , A61K51/0491 , C12N15/111 , C12N2310/16 , C12N2310/351 , C12N2320/13 , C12N2320/31 , G01N33/57434 , G01N33/57492
摘要： The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
摘要翻译： 本发明为PSMA提供稳定的高亲和力核酸配体。 本文描述了使用具有2'-O-甲基取代的核酸的SELEX TM方法和细胞表面SELEX TM来鉴定和制备新的，稳定的，高亲和力的PSMA配体的方法。 还包括使用所述核酸配体治疗和诊断以PSMA表达为特征的疾病的方法和组合物。
-
2.发明授权Stabilized aptamers to PSMA and their use as prostate cancer therapeutics 失效PSMA的稳定适体及其作为前列腺癌治疗剂的用途公开(公告)号：US07767803B2
公开(公告)日：2010-08-03
申请号：US11370491
申请日：2006-03-07
申请人： John L. Diener , Paul Hatala , Jess Wagner-Whyte , Charles Wilson
发明人： John L. Diener , Paul Hatala , Jess Wagner-Whyte , Charles Wilson
IPC分类号： A61K21/00
CPC分类号： A61K51/0491 , A61K31/787 , A61K47/549 , A61K47/60 , B82Y5/00
摘要： The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
摘要翻译： 本发明为PSMA提供稳定的高亲和力核酸配体。 本文描述了使用具有2'-O-甲基取代的核酸的SELEX TM方法和细胞表面SELEX TM来鉴定和制备PSMA的新的，稳定的，高亲和力配体的方法。 还包括使用所述核酸配体治疗和诊断以PSMA表达为特征的疾病的方法和组合物。
-
3.发明申请Stabilized aptamers to PSMA and their use as prostate cancer therapeutics 失效PSMA的稳定适体及其作为前列腺癌治疗剂的用途公开(公告)号：US20070041901A1
公开(公告)日：2007-02-22
申请号：US11370491
申请日：2006-03-07
申请人： John Diener , Paul Hatala , Jess Wagner-Whyte , Charles Wilson
发明人： John Diener , Paul Hatala , Jess Wagner-Whyte , Charles Wilson
IPC分类号： A61K51/00 , A61K48/00 , A61K39/395 , A61K31/787 , C07K16/46
CPC分类号： A61K51/0491 , A61K31/787 , A61K47/549 , A61K47/60 , B82Y5/00
摘要： The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
摘要翻译： 本发明为PSMA提供稳定的高亲和力核酸配体。 本文描述了使用具有2'-O-甲基取代的核酸的SELEX TM方法和细胞表面SELEX TM来鉴定和制备新的，稳定的，高亲和力的PSMA配体的方法。 还包括使用所述核酸配体治疗和诊断以PSMA表达为特征的疾病的方法和组合物。
-
4.发明授权Methods of separating biopolymer conjugated molecules from unconjugated molecules 有权将生物聚合物共轭分子与未共轭分子分离的方法公开(公告)号：US08207298B2
公开(公告)日：2012-06-26
申请号：US12434170
申请日：2009-05-01
申请人： Paul Hatala , William J. Issa
发明人： Paul Hatala , William J. Issa
摘要： The invention relates to methods for separating or purifying biopolymer conjugated molecules from unconjugated molecules. In particular, methods are described for purifying a PEGylated protein or oligonucleotide from an unPEGylated protein or oligonucleotide, respectively. The methods are quick and efficient separation methods because they do not require gradient chromatography, fractionation of an eluent or analysis of the eluted fractions. Further, the methods increase yield and purity of the biopolymer conjugated molecule.
摘要翻译： 本发明涉及从未共轭分子分离或纯化生物聚合物共轭分子的方法。 特别地，描述了分别从未PEG化的蛋白质或寡核苷酸纯化聚乙二醇化蛋白质或寡核苷酸的方法。 这些方法是快速有效的分离方法，因为它们不需要梯度色谱法，洗脱液分离或洗脱级分的分析。 此外，该方法提高生物聚合物共轭分子的产率和纯度。
-
5.发明申请Methods of Separating Biopolymer Conjugated Molecules From Unconjugated Molecules 有权从非共轭分子分离生物聚合物共轭分子的方法公开(公告)号：US20090286955A1
公开(公告)日：2009-11-19
申请号：US12434170
申请日：2009-05-01
申请人： Paul Hatala , William J. Issa
发明人： Paul Hatala , William J. Issa
摘要： The invention relates to methods for separating or purifying biopolymer conjugated molecules from unconjugated molecules. In particular, methods are described for purifying a PEGylated protein or oligonucleotide from an unPEGylated protein or oligonucleotide, respectively. The methods are quick and efficient separation methods because they do not require gradient chromatography, fractionation of an eluent or analysis of the eluted fractions. Further, the methods increase yield and purity of the biopolymer conjugated molecule.
摘要翻译： 本发明涉及从未共轭分子分离或纯化生物聚合物共轭分子的方法。 特别地，描述了分别从未PEG化的蛋白质或寡核苷酸纯化聚乙二醇化蛋白质或寡核苷酸的方法。 这些方法是快速有效的分离方法，因为它们不需要梯度色谱法，洗脱液分离或洗脱级分的分析。 此外，该方法提高生物聚合物共轭分子的产率和纯度。
-
-
-
-
搜索结果
5 条记录 (耗时 0.025 秒)