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14 条记录 (耗时 0.019 秒)

    MULTIPARTICULATE FORMULATION HAVING TRAMADOL IN IMMEDIATE AND CONTROLLED RELEASE FORM
    4.
    发明申请
    MULTIPARTICULATE FORMULATION HAVING TRAMADOL IN IMMEDIATE AND CONTROLLED RELEASE FORM 审中-公开
    立即释放TRAMADOL的多制剂配方及控制释放形式

    公开(公告)号：US20100047343A1

    公开(公告)日：2010-02-25

    申请号：US12608686

    申请日：2009-10-29

    申请人： John L. Haslam ,  Roger A. Rajewski

    发明人： John L. Haslam ,  Roger A. Rajewski

    IPC分类号： A61K9/58 ,  A61K31/135 ,  A61K9/16

    CPC分类号： A61K9/5084

    摘要： A multi-particulate pharmaceutical composition of rapid release particles and controlled release particles comprising tramadol or a salt thereof is provided. The composition provides a rapid and controlled release of tramadol or a salt thereof in a substantially pH independent manner after oral administration to a subject. The composition can be included in a capsule, caplet, sachet, or other solid dosage form adapted to retain and then release solid pharmaceutical compositions.

    摘要翻译： 提供了包含曲马多或其盐的快速释放颗粒和控制释放颗粒的多颗粒药物组合物。 组合物在口服给予受试者后，以基本上不依赖于pH的方式提供曲马多或其盐的快速和控制释放。 组合物可以包含在适于保持固体药物组合物并随后释放的胶囊，囊袋，小袋或其它固体剂型中。

    Eye frame ophthalmic drug delivery device
    9.
    发明授权
    Eye frame ophthalmic drug delivery device 失效
    眼框眼药物输送装置

    公开(公告)号：US4573982A

    公开(公告)日：1986-03-04

    申请号：US550427

    申请日：1983-11-10

    申请人： Alexander E. Forbes ,  John L. Haslam

    发明人： Alexander E. Forbes ,  John L. Haslam

    IPC分类号： G02C1/00 ,  A61F9/00 ,  A61M35/00 ,  G02C11/00

    CPC分类号： G02C11/00 ,  A61F9/0008 ,  A61F9/0026

    摘要： This invention relates to an eyeglass frame mounted unit dose ophthalmic drug delivery device. A unit dose of ophthalmic medicament is provided by either a preloaded disposable microsyringe, preloaded disposable tip or manually loaded calibrated microsyringe rigidly mounted on a block which itself is slidably mounted to the eyeglass frame. The device allows for the insertion of ophthalmic medication into the inferior cul de sac of the eye.

    摘要翻译： 本发明涉及眼镜架安装的单位剂量眼药物递送装置。 眼药物的单位剂量由预先装入的一次性微量注射器，预加载的一次性尖端或刚性地安装在其自身可滑动地安装到眼镜框上的块上的手动加载的校准微量注射器提供。 该装置允许将眼药物插入眼睛的下颌囊中。

    Multiparticulate controlled porosity osmotic pump
    10.
    发明授权
    Multiparticulate controlled porosity osmotic pump 失效
    多粒度控制孔隙渗透泵

    公开(公告)号：US4886668A

    公开(公告)日：1989-12-12

    申请号：US100676

    申请日：1987-09-24

    申请人： John L. Haslam ,  Gerald S. Rork

    发明人： John L. Haslam ,  Gerald S. Rork

    IPC分类号： A61K9/00 ,  A61K31/55

    CPC分类号： A61K9/0004 ,  A61K31/55

    摘要： The instant invention is directed to a multiparticulate osmotic pump, for the controlled release of diltiazem L-malate to an environment of use, said pump comprising:(I) a carrier medium which does not maintain its integrity in the environment of use;(II) a multiple of tiny osmotic pump elements each comprising:(A) a core comprises diltiazem L-malate and an effective buffering amount of sodium bitartrate surrounded by(B) a rate controlling water insoluble wall, having a fluid permeability of 6.96.times.10.sup.-18 to 6.96.times.10.sup.-14 cm.sup.3 sec/g and a reflection coefficient of less than 0.5, prepared from:(i) a polymer permeable to water but impermeable to solute and(ii) 0.1 to 60% by weight, based on the total weight of (i) and (ii), of at least one pH insensitive pore forming additive dispersed throughout said wall,wherein the total amount of diltiazem L-malate in all of the osmotic pump elements is a therapeutically effective amount.

    摘要翻译： 本发明涉及一种多颗粒渗透泵，用于将地尔硫卓L-苹果酸盐控制释放到使用环境中，所述泵包括：（I）在使用环境中不保持其完整性的载体介质; （II）多个微小的渗透泵元件，每个包含：（A）核心包括地尔硫卓L-苹果酸盐和有效缓冲量的由（B）速率控制水不溶性壁包围的硼酸酒石酸钠，其流体渗透性为6.96×10 -18至6.96×10 14 cm 3 / g和反射系数小于0.5，由以下因素制备：（i）可渗透水但不溶于溶质的聚合物，和（ii）基于总计的0.1-60重量％ 分散在整个壁上的至少一种pH不敏感的形成孔的添加剂的（i）和（ii）的重量，其中所有渗透泵元件中的地尔硫卓L-苹果酸盐的总量是治疗有效量。