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    Diluent, methods of manufacture and use
    2.
    发明申请
    Diluent, methods of manufacture and use 审中-公开
    稀释剂，制造和使用方法

    公开(公告)号：US20060121627A1

    公开(公告)日：2006-06-08

    申请号：US11325899

    申请日：2006-01-05

    申请人： John Lynch ,  Alan Weiss

    发明人： John Lynch ,  Alan Weiss

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54393

    摘要： The use of diluent to reduce non-specific drug binding (NSB) provides a simple, flexible and biocompatible way to reduce chemical entity (such as drugs, drug candidates and other small molecules) NSB so that bioassay results may more closely predict the behavior of these compounds in vitro. Additionally, the use of diluent as the chemical entity diluent enhances the predictive nature of data emanating from high throughput drug assays such as Caco-2 drug transport assays, plasma protein drug binding assays, PAMPA assays, permeability assays, and drug solubility assays. The diluent is made by either filtering a selected plasma through an ultrafiltration membrane having nominal molecular weight cutoff of about 30 kD, preferably about 10 kD or below or by selectively adding individual components of a plasma or serum that do not contribute to non-specific binding.

    摘要翻译： 使用稀释剂来减少非特异性药物结合（NSB）提供了一种简单，灵活和生物相容的方法来减少化学实体（如药物，药物候选物和其他小分子）NSB，以便生物测定结果可以更加密切地预测 这些化合物在体外。 另外，使用稀释剂作为化学实体稀释剂增强了从高通量药物测定（例如Caco-2药物转运测定法，血浆蛋白质药物结合测定法，PAMPA测定法，渗透性测定法和药物溶解度测定）中发出的数据的预测性质。 稀释剂通过将选定的血浆过滤通过具有约30kD，优选约10kD或更低的标称分子量截留值的超滤膜或通过选择性加入不对非特异性结合有贡献的血浆或血清的各成分来制备 。

    Diluent, methods of manufacture and use
    3.
    发明申请
    Diluent, methods of manufacture and use 审中-公开
    稀释剂，制造和使用方法

    公开(公告)号：US20080193913A1

    公开(公告)日：2008-08-14

    申请号：US12082376

    申请日：2008-04-10

    申请人： John Lynch ,  Alan Weiss

    发明人： John Lynch ,  Alan Weiss

    IPC分类号： A01N1/02

    CPC分类号： G01N33/54393

    摘要： The use of diluent to reduce non-specific drug binding (NSB) provides a simple, flexible and biocompatible way to reduce chemical entity (such as drugs, drug candidates and other small molecules) NSB so that bioassay results may more closely predict the behavior of these compounds in vitro. Additionally, the use of diluent as the chemical entity diluent enhances the predictive nature of data emanating from high throughput drug assays such as Caco-2 drug transport assays, plasma protein drug binding assays, PAMPA assays, permeability assays, and drug solubility assays. The diluent is made by either filtering a selected plasma through an ultrafiltration membrane having nominal molecular weight cutoff of about 30 kD, preferably about 10 kD or below or by selectively adding individual components of a plasma or serum that do not contribute to non-specific binding.

    摘要翻译： 使用稀释剂来减少非特异性药物结合（NSB）提供了一种简单，灵活和生物相容的方法来减少化学实体（如药物，药物候选物和其他小分子）NSB，以便生物测定结果可以更加密切地预测 这些化合物在体外。 另外，使用稀释剂作为化学实体稀释剂增强了从高通量药物测定（例如Caco-2药物转运测定法，血浆蛋白质药物结合测定法，PAMPA测定法，渗透性测定法和药物溶解度测定）中发出的数据的预测性质。 稀释剂通过将选定的血浆过滤通过具有约30kD，优选约10kD或更低的标称分子量截留值的超滤膜或通过选择性加入不对非特异性结合有贡献的血浆或血清的各成分来制备 。

    Diluent, methods of manufacturing and use
    4.
    发明申请
    Diluent, methods of manufacturing and use 审中-公开
    稀释剂，制造和使用方法

    公开(公告)号：US20080044929A1

    公开(公告)日：2008-02-21

    申请号：US11975768

    申请日：2007-10-22

    申请人： John Lynch ,  Alan Weiss

    发明人： John Lynch ,  Alan Weiss

    IPC分类号： G01N33/536

    CPC分类号： G01N33/54393

    摘要： The use of diluent to reduce non-specific,drug binding (NSB) provides a simple, flexible and biocompatible way to reduce chemical entity (such as drugs, drug candidates and other small molecules) NSB so that bioassay results may more closely predict the behavior of these compounds in vitro. Additionally, the use of diluent as the chemical entity diluent enhances the predictive nature of data emanating from high throughput drug assays such as Caco-2 drug transport assays, plasma protein drug binding assays, PAMPA assays, permeability assays, and drug solubility assays. The diluent is made by either filtering a selected plasma through an ultrafiltration membrane having nominal molecular weight cutoff of about 30 kD, preferably about 10 kD or below or by selectively adding individual components of a plasma or serum that do not contribute to non-specific binding.

    摘要翻译： 使用稀释剂降低非特异性，药物结合（NSB）提供了一种简单，灵活和生物相容的方法来减少化学实体（如药物，药物候选物和其他小分子）NSB，以便生物测定结果可能更密切地预测行为 的这些化合物。 另外，使用稀释剂作为化学实体稀释剂增强了从高通量药物测定（例如Caco-2药物转运测定法，血浆蛋白质药物结合测定法，PAMPA测定法，渗透性测定法和药物溶解度测定）中发出的数据的预测性质。 稀释剂通过将选定的血浆过滤通过具有约30kD，优选约10kD或更低的标称分子量截留值的超滤膜或通过选择性加入不对非特异性结合有贡献的血浆或血清的各成分来制备 。

    Gaming device and method for providing player selection of modifiers to game components
    5.
    发明授权
    Gaming device and method for providing player selection of modifiers to game components 有权
    游戏装置和方法，用于向游戏组件提供玩家选择修饰符

    公开(公告)号：US08721429B2

    公开(公告)日：2014-05-13

    申请号：US13571205

    申请日：2012-08-09

    申请人： Scott A. Caputo ,  Carl V. Kniesteadt ,  Alan Weiss

    发明人： Scott A. Caputo ,  Carl V. Kniesteadt ,  Alan Weiss

    IPC分类号： A63F9/24 ,  A63F13/00 ,  G06F17/00 ,  G06F19/00

    CPC分类号： G07F17/3244 ,  G07F17/32 ,  G07F17/3209 ,  G07F17/3211 ,  G07F17/3213 ,  G07F17/3223 ,  G07F17/3225 ,  G07F17/3258 ,  G07F17/326 ,  G07F17/3262 ,  G07F17/3267 ,  G07F17/3293 ,  G07F17/34

    摘要： In one embodiment, the gaming device and method disclosed herein provides a player one or more modifiers to apply to different components or characteristics of a game. In one such embodiment, the gaming device enables a player to selectively apply or associate a plurality of modifiers to a single game component or apply the plurality of modifiers across the plurality of game components. For each game component with at least one applied modifier, the gaming device disclosed herein modifies said game component based on each applied modifier. The gaming device generates any awards based on any modified game components and any unmodified game components and provides any generated awards to the player.

    摘要翻译： 在一个实施例中，本文公开的游戏设备和方法为游戏者提供一个或多个修改器以应用于游戏的不同组件或特征。 在一个这样的实施例中，游戏装置使得玩家能够选择性地将多个修饰符应用于或连接到单个游戏组件，或者跨多个游戏组件应用多个修饰符。 对于具有至少一个应用的修饰符的每个游戏组件，本文公开的游戏设备基于每个应用的修饰符修改所述游戏组件。 游戏设备基于任何修改的游戏组件和任何未修改的游戏组件产生任何奖励，并向玩家提供任何生成的奖励。

    Loudspeaker with tapered slot coupler and sound reproduction system
    6.
    发明授权
    Loudspeaker with tapered slot coupler and sound reproduction system 失效
    扬声器带锥形槽耦合器和声音再现系统

    公开(公告)号：US5943431A

    公开(公告)日：1999-08-24

    申请号：US812766

    申请日：1997-03-06

    申请人： Alan Weiss ,  Thomas Brown

    发明人： Alan Weiss ,  Thomas Brown

    IPC分类号： H04R1/34 ,  H04R25/00

    CPC分类号： H04R1/345

    摘要： In accordance with the invention, there is provided a tapered slot coupler combined with a loudspeaker for providing a high degree of uniform angular sound distribution in the horizontal plane, and a sharp cut-off above the horizontal plane through the coupler-speaker combination. It also sends a greater amount of sound energy to the furthest point of the domain and diminishing energy in direction to the interior of the domain as one comes closer and closer to the sound source. A sound reproduction system cooperating with the coupler-speaker combination has a receiving domain for receiving the sound, a perimeter defining the domain, and a plurality of tapered slot high and medium frequency coupler-speakers disposed proximal to the perimeter facing the domain, and a plurality of low frequency loudspeakers also disposed along the perimeter facing the domain, wherein the high/medium frequency loudspeakers are of the tapered slot coupler-speaker combination type. The invention includes sound-energy generating apparatus operative for feeding sound energy to the speakers.

    摘要翻译： 根据本发明，提供了一种与扬声器组合的锥形槽式联接器，用于在水平面中提供高度均匀的角度声音分布，以及通过耦合器 - 扬声器组合在水平面上方的锐利截止。 它还向该领域的最远点发送更大量的声能，并且随着越来越接近声源而朝向内部内部的方向减少能量。 与耦合器 - 扬声器组合协作的声音再现系统具有用于接收声音的接收区域，界定该区域的周边，以及靠近面向该区域的周边设置的多个锥形槽高和中频耦合器扬声器，以及 多个低频扬声器也沿着面向域的周边设置，其中高/中频扬声器是锥形槽耦合器 - 扬声器组合型。 本发明包括可操作以将声能馈送到扬声器的声能发生装置。

    GAMING DEVICE AND METHOD FOR PROVIDING PLAYER SELECTION OF MODIFIERS TO GAME COMPONENTS
    7.
    发明申请
    GAMING DEVICE AND METHOD FOR PROVIDING PLAYER SELECTION OF MODIFIERS TO GAME COMPONENTS 有权
    游戏设备和方法，用于提供播放器选择游戏组件的修改器

    公开(公告)号：US20120302317A1

    公开(公告)日：2012-11-29

    申请号：US13571217

    申请日：2012-08-09

    申请人： Scott A. Caputo ,  Carl V. Kniesteadt ,  Alan Weiss

    发明人： Scott A. Caputo ,  Carl V. Kniesteadt ,  Alan Weiss

    IPC分类号： A63F13/00 ,  A63F13/12

    CPC分类号： G07F17/3244 ,  G07F17/32 ,  G07F17/3209 ,  G07F17/3211 ,  G07F17/3213 ,  G07F17/3223 ,  G07F17/3225 ,  G07F17/3258 ,  G07F17/326 ,  G07F17/3262 ,  G07F17/3267 ,  G07F17/3293 ,  G07F17/34

    摘要： In one embodiment, the gaming device and method disclosed herein provides a player one or more modifiers to apply to different components or characteristics of a game. In one such embodiment, the gaming device enables a player to selectively apply or associate a plurality of modifiers to a single game component or apply the plurality of modifiers across the plurality of game components. For each game component with at least one applied modifier, the gaming device disclosed herein modifies said game component based on each applied modifier. The gaming device generates any awards based on any modified game components and any unmodified game components and provides any generated awards to the player.

    摘要翻译： 在一个实施例中，本文公开的游戏设备和方法为游戏者提供一个或多个修改器以应用于游戏的不同组件或特征。 在一个这样的实施例中，游戏装置使得玩家能够选择性地将多个修饰符应用于或连接到单个游戏组件，或者跨多个游戏组件应用多个修饰符。 对于具有至少一个应用的修饰符的每个游戏组件，本文公开的游戏设备基于每个应用的修饰符修改所述游戏组件。 游戏设备基于任何修改的游戏组件和任何未修改的游戏组件产生任何奖励，并向玩家提供任何生成的奖励。

    Gaming device and method for providing player selection of modifiers to game components
    8.
    发明授权
    Gaming device and method for providing player selection of modifiers to game components 有权
    游戏装置和方法，用于向游戏组件提供玩家选择修饰符

    公开(公告)号：US08986100B2

    公开(公告)日：2015-03-24

    申请号：US13571217

    申请日：2012-08-09

    申请人： Scott A. Caputo ,  Carl V. Kniesteadt ,  Alan Weiss

    发明人： Scott A. Caputo ,  Carl V. Kniesteadt ,  Alan Weiss

    IPC分类号： G06F17/00 ,  G06F19/00 ,  G07F17/32

    CPC分类号： G07F17/3244 ,  G07F17/32 ,  G07F17/3209 ,  G07F17/3211 ,  G07F17/3213 ,  G07F17/3223 ,  G07F17/3225 ,  G07F17/3258 ,  G07F17/326 ,  G07F17/3262 ,  G07F17/3267 ,  G07F17/3293 ,  G07F17/34

    摘要： In one embodiment, the gaming device and method disclosed herein provides a player one or more modifiers to apply to different components or characteristics of a game. In one such embodiment, the gaming device enables a player to selectively apply or associate a plurality of modifiers to a single game component or apply the plurality of modifiers across the plurality of game components. For each game component with at least one applied modifier, the gaming device disclosed herein modifies said game component based on each applied modifier. The gaming device generates any awards based on any modified game components and any unmodified game components and provides any generated awards to the player.

    摘要翻译： 在一个实施例中，本文公开的游戏设备和方法为游戏者提供一个或多个修改器以应用于游戏的不同组件或特征。 在一个这样的实施例中，游戏装置使得玩家能够选择性地将多个修饰符应用于或连接到单个游戏组件，或者跨多个游戏组件应用多个修饰符。 对于具有至少一个应用的修饰符的每个游戏组件，本文公开的游戏设备基于每个应用的修饰符修改所述游戏组件。 游戏设备基于任何修改的游戏组件和任何未修改的游戏组件产生任何奖励，并向玩家提供任何生成的奖励。

    Stable electro-mechanical actuators
    9.
    发明授权
    Stable electro-mechanical actuators 有权
    稳定的机电执行器

    公开(公告)号：US08269396B2

    公开(公告)日：2012-09-18

    申请号：US13036724

    申请日：2011-02-28

    申请人： Vladimir Anatolyevich Aksyuk ,  Carl Jeremy Nuzman ,  Maria Elina Simon ,  Alan Weiss

    发明人： Vladimir Anatolyevich Aksyuk ,  Carl Jeremy Nuzman ,  Maria Elina Simon ,  Alan Weiss

    IPC分类号： H02N2/00 ,  G02B26/08

    CPC分类号： H02N1/008 ,  G02B7/1827 ,  G02B26/0841

    摘要： An electro-mechanical actuator includes a comb drive and a deformable connector. The comb drive has a first capacitor plate and a second capacitor plate. The capacitor plates have teeth capable of inter-digitating. The deformable connector is configured to apply a mechanical restoring force to the first capacitor plate. The deformable connector is configured to restore the first capacitor plate to be at an equilibrium rest position in response to no control voltage being applied across the capacitor. The comb drive is more engaged at the equilibrium rest position than at a mechanical stability threshold of the comb drive. The capacitor plates are disengaged at the equilibrium rest position.

    摘要翻译： 机电致动器包括梳状驱动器和可变形连接器。 梳状驱动器具有第一电容器板和第二电容器板。 电容器板具有能够进行数字化的齿。 可变形连接器构造成对第一电容器板施加机械恢复力。 可变形连接器被配置为响应于不跨越电容器施加控制电压而将第一电容器板恢复到平衡静止位置。 梳齿驱动器在平衡静止位置比在梳齿驱动器的机械稳定性阈值处更多地啮合。 电容器板在平衡静止位置脱离。