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公开(公告)号：US20050266577A1
公开(公告)日：2005-12-01
申请号：US11195517
申请日：2005-08-02
申请人： John Lynch , Michele Dumon , Alan Weiss , Kenneth Desilets , Stephane Olivier
发明人： John Lynch , Michele Dumon , Alan Weiss , Kenneth Desilets , Stephane Olivier
CPC分类号： G01N1/4005 , B01D61/18 , B01D63/081 , B01D2315/08 , B01L3/50255 , B01L2200/0631 , B01L2300/0829 , G01N2001/4016
摘要： The combination of a supported UF membrane having low non-specific binding (NSB) and high protein retention of the tested chemical entity (CE) in a device that is SBS complaint. The membrane is heat sealed to form one or more integral wells that are used to reduce NSB and improve protein retention and provides a simple, flexible way to reduce CE, such as drug and drug candidate (and other small molecule) NSB so that drug binding studies may more closely predict the behavior of these compounds in vivo.
摘要翻译： 在SBS投诉的装置中，具有低非特异性结合（NSB）的支持的UF膜和测试化学实体（CE）的高蛋白质保留的组合。 膜被热密封以形成一个或多个用于减少NSB并改善蛋白质保留的整合孔，并提供简单，灵活的方式来减少CE，例如药物和药物候选物（和其他小分子）NSB，使得药物结合 研究可能更密切地预测这些化合物在体内的行为。
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公开(公告)号：US20050051471A1
公开(公告)日：2005-03-10
申请号：US10655052
申请日：2003-09-04
申请人： Joseph Lane , Louis Bonhomme , Douglas Boucher , Richard Burnham , Kenneth Desilets , Luc Lirot , Stephane Olivier , Steven Sheridan
发明人： Joseph Lane , Louis Bonhomme , Douglas Boucher , Richard Burnham , Kenneth Desilets , Luc Lirot , Stephane Olivier , Steven Sheridan
CPC分类号： B01L3/50255 , B01L2300/0848
摘要： The present invention provides an underdrain having an improved spout. The underdrain has particular utility in the construction of both single-well and microarray filtration devices. In a principal embodiment, the underdrain is characterized by its incorporation of a straight-walled, roughly-textured spout, the spout being provided with microhole(s) at a terminal end thereof for the discharge of fluid conducted through the underdrain. An array comprising several of such underdrains can be mated with a corresponding array of wells, with separation material (e.g., membrane material) provided therebetween. The resultant microarray filtration device can be used for conducting several fluid assays contemporaneously with, for example, good “pendant drop” control and low “cross-talk”.
摘要翻译： 本发明提供了一种具有改进的喷口的暗渠。 缺水在单井和微阵列过滤装置的构建中具有特殊的用途。 在一个主要实施方案中，缺油的特征在于其结合了直壁的大致纹理的喷口，喷嘴在其末端处设置有微孔，用于排出通过漏斗传导的流体。 包括若干这样的下水道的阵列可以与相应的孔阵列配合，其间设置有分离材料（例如膜材料）。 所得到的微阵列过滤装置可用于与例如良好的“悬滴”控制和低“串扰”同时进行几种流体测定。
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公开(公告)号：US20050095175A1
公开(公告)日：2005-05-05
申请号：US10961778
申请日：2004-10-08
CPC分类号： B01L3/50255 , B01L2200/141 , B01L2300/0829 , B01L2400/049
摘要： Underdrain design for a multiwell device that when fixed to the device (either as an integral or removable component thereof), allows for adequate venting during filtration, minimizes or prevents air lock, and has improved structural integrity. Also disclosed is a laboratory device designed particularly for a multiplate format that includes a plate or tray having a plurality of wells, and an underdrain in fluid communication with each of the plurality of wells. The underdrain can be a separate, removable piece, or can be an integral unitary structure with the plate or tray forming a one-piece design. The design is preferably in compliance with SBS format.
摘要翻译： 用于多孔设备的暗槽设计，当固定到设备（作为其整体或可移除部件）时，允许在过滤期间充分排气，最小化或防止气锁，并且具有改善的结构完整性。 还公开了一种特别设计用于多种格式的实验室装置，其包括具有多个孔的板或托盘，以及与多个孔中的每一个流体连通的暗槽。 下划线可以是单独的可拆卸件，或者可以是整体的单一结构，其中板或托盘形成一体式设计。 该设计优选地符合SBS格式。
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公开(公告)号：US09028779B2
公开(公告)日：2015-05-12
申请号：US12638242
申请日：2009-12-15
申请人： Stephane Olivier
发明人： Stephane Olivier
CPC分类号： B65B3/26 , G01N1/18 , G01N35/1079 , G01N2001/1037 , G01N2001/2085
摘要： The device for the transfer of a medium comprises a magazine (2) and at least one transfer element (3) for transfer of said medium, said transfer element (3) comprising a duct (45) for transfer of said medium provided at one end with a needle (31), a septum (32), and a maneuvering unit (33) of said needle (31), said transfer element (3) also comprising means for locking (61, 65) adapted to cooperate with complementary locking means (15) of said magazine (2) to lock said needle (31) in a waiting position, said locking means (61, 62, 65) belonging to said maneuvering unit (33) and cooperating with said complementary locking means (15) at a location of said magazine (2) distinct from the location through which said duct (45) issues from the cavity (20), at the opposite end from the needle (31).
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公开(公告)号：US08353537B2
公开(公告)日：2013-01-15
申请号：US13231247
申请日：2011-09-13
申请人： Stephane Olivier
发明人： Stephane Olivier
IPC分类号： F16L25/00
CPC分类号： F16L37/36 , A61M39/10 , A61M39/18 , A61M2039/1044 , F16L2201/44 , Y10S604/905 , Y10T403/16
摘要： A male-female connection device, wherein the male connection device includes a sleeve and a slide that is adapted to occupy, relative to the sleeve, a position in which the slide is advanced in the sleeve, the device also including a tubular film folded back on itself and pressed between the slide and the sleeve. The female connection device includes a sleeve and a slide that is adapted to occupy, relative to the sleeve, a position in which the slide is set back in the sleeve, the device also including a tubular film folded back on itself and pressed between the slide and the sleeve. The male and female connection devices can be engaged within each other.
摘要翻译： 公 - 母连接装置，其中所述阳连接装置包括套筒和适于相对于所述套筒占据所述滑块在所述套筒中前进的位置的滑块，所述装置还包括折叠的管状薄膜 并且在滑块和套筒之间按压。 阴连接装置包括套筒和滑动件，其适于相对于套筒占据滑动件在套筒中回缩的位置，该装置还包括折叠在其上并压在滑块之间的管状薄膜 和袖子。 公母连接装置可以彼此接合。
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公开(公告)号：US20110189725A1
公开(公告)日：2011-08-04
申请号：US13088632
申请日：2011-04-18
申请人： Stephane Olivier , Mathieu Arrault
发明人： Stephane Olivier , Mathieu Arrault
IPC分类号： C12Q1/02
摘要： The assembly comprises a filtration unit (1) and a gel growth medium cassette (80), the unit (1) and the cassette (80) being adapted to cooperate in order to occupy a nested position in which a membrane (3) covers the said gel growth medium (88), the said unit (1) and the said cassette (80) each being equipped with an intermediate stop (26, 100), it being possible for at least one of the two stops (100) to move clear so as to allow the said unit (1) to move from an intermediate position, in which the said membrane is spaced away from the said gel growth medium, into the said nested position.The method comprises the steps of selecting such an assembly, of engaging the said unit (1) on the said cassette (80) until the intermediate stop (26) of the said unit (1) comes into contact with the intermediate stop (100) of the said cassette (80), and the step of moving clear the said stop (100) able to move clear so as to allow the said unit (1) to move from the said intermediate position into the said nested position.
摘要翻译： 组合件包括过滤单元（1）和凝胶生长培养基盒（80），单元（1）和盒（80）适于协作以便占据其中膜（3）覆盖的嵌套位置 所述凝胶生长培养基（88），所述单元（1）和所述盒（80）各自配备有中间停止件（26,100），所述两个止挡件（100）中的至少一个能够移动 透明以允许所述单元（1）从所述膜与所述凝胶生长介质间隔开的中间位置移动到所述嵌套位置。 该方法包括以下步骤：选择这样的组件，使所述单元（1）与所述盒（80）接合，直到所述单元（1）的中间挡块（26）与中间止挡（100）接触， ，并且移动所述止动件（100）的移动能够移动清除以允许所述单元（1）从所述中间位置移动到所述嵌套位置的步骤。
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公开(公告)号：US09102909B2
公开(公告)日：2015-08-11
申请号：US13088632
申请日：2011-04-18
申请人： Stephane Olivier , Mathieu Arrault
发明人： Stephane Olivier , Mathieu Arrault
摘要： The assembly comprises a filtration unit and a gel growth medium cassette, the unit and the cassette being adapted to cooperate in order to occupy a nested position in which a membrane covers the gel growth medium, the unit and the cassette each being equipped with an intermediate stop, it being possible for at least one of the two stops to move clear so as to allow the unit to move from an intermediate position, in which the membrane is spaced away from the said gel growth medium, into the nested position. The method comprises selecting such an assembly, of engaging the unit on the cassette until the intermediate stop of the unit comes into contact with the intermediate stop of the cassette, and the step of moving clear the stop able to move clear so as to allow the unit to move from the intermediate position into the nested position.
摘要翻译： 所述组件包括过滤单元和凝胶生长培养基盒，所述单元和所述盒适于协作以便占据其中膜覆盖所述凝胶生长培养基的嵌套位置，所述单元和所述盒各配有中间体 停止，两个止动件中的至少一个可以移动清除，以便允许单元从膜中间离开所述凝胶生长介质的中间位置移动到嵌套位置。 该方法包括：选择这样的组件，使单元与盒上的单元接合，直到单元的中间停止与盒的中间止挡接触，并且移动清除能够移动清除的停止的步骤，以便允许 单位从中间位置移动到嵌套位置。
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公开(公告)号：US08152203B2
公开(公告)日：2012-04-10
申请号：US12459633
申请日：2009-07-06
申请人： Stephane Olivier
发明人： Stephane Olivier
IPC分类号： F16L25/00
CPC分类号： F16L37/36 , A61M39/10 , A61M39/18 , A61M2039/1044 , F16L2201/44 , Y10S604/905 , Y10T403/16
摘要： The male connection device comprises a sleeve (4) and a slide (5) that is adapted to occupy, relative to said sleeve (4), a position in which said slide (5) is advanced in said sleeve (4), said device also comprising a tubular film (6) folded back on itself and pressed between the slide (5) and the sleeve (4).The female connection device comprises a sleeve (40) and a slide (41) that is adapted to occupy, relative to said sleeve (40), a position in which said slide (41) is set back in said sleeve (40), said device also comprising a tubular film (42) folded back on itself and pressed between the slide (41) and the sleeve (40).The male-female connection system comprises such a male connection device (2) and such a female connection device (3) which are provided to be engaged within each other.
摘要翻译： 阳连接装置包括套筒（4）和滑动件（5），其适于相对于所述套筒（4）占据所述滑动件（5）在所述套筒（4）中前进的位置，所述装置 还包括在其自身上折叠并压在滑动件（5）和套筒（4）之间的管状薄膜（6）。 阴连接装置包括套筒（40）和适于相对于所述套筒（40）占据所述滑动件（41）放置在所述套筒（40）中的位置的滑动件（41），所述滑动件 装置还包括折叠回自身并被压在滑动件（41）和套筒（40）之间的管状薄膜（42）。 公 - 母连接系统包括这样的阳连接装置（2）和这样的阴连接装置（3），它们被设置成彼此接合。
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公开(公告)号：US20080268422A1
公开(公告)日：2008-10-30
申请号：US12082712
申请日：2008-04-14
申请人： Stephane Olivier , Mathieu Arrault
发明人： Stephane Olivier , Mathieu Arrault
摘要： The assembly comprises a filtration unit (1) and a gel growth medium cassette (80), the unit (1) and the cassette (80) being adapted to cooperate in order to occupy a nested position in which a membrane (3) covers the said gel growth medium (88), the said unit (1) and the said cassette (80) each being equipped with an intermediate stop (26, 100), it being possible for at least one of the two stops (100) to move clear so as to allow the said unit (1) to move from an intermediate position, in which the said membrane is spaced away from the said gel growth medium, into the said nested position.The method comprises the steps of selecting such an assembly, of engaging the said unit (1) on the said cassette (80) until the intermediate stop (26) of the said unit (1) comes into contact with the intermediate stop (100) of the said cassette (80), and the step of moving clear the said stop (100) able to move clear so as to allow the said unit (1) to move from the said intermediate position into the said nested position.
摘要翻译： 组合件包括过滤单元（1）和凝胶生长培养基盒（80），单元（1）和盒（80）适于协作以便占据其中膜（3）覆盖的嵌套位置 所述凝胶生长培养基（88），所述单元（1）和所述盒（80）各自配备有中间停止件（26,100），所述两个止挡件（100）中的至少一个能够移动 透明以允许所述单元（1）从所述膜与所述凝胶生长介质间隔开的中间位置移动到所述嵌套位置。 该方法包括以下步骤：选择这样的组件，使所述单元（1）与所述盒（80）接合，直到所述单元（1）的中间挡块（26）与中间止挡（100）接触， ，并且移动所述止动件（100）的移动能够移动清除以允许所述单元（1）从所述中间位置移动到所述嵌套位置的步骤。
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公开(公告)号：US20060002805A1
公开(公告)日：2006-01-05
申请号：US11152517
申请日：2005-06-14
CPC分类号： F04B43/1284
摘要： The peristaltic pump (1) comprises a rotor with rollers, a mobile jaw having an open position and a closed position, and further comprises, on each side of the rotor, a locating member for said tube adapted to receive it when it is pressed in and to allow it to slide in the longitudinal direction in which the locating member extends, said locating members being disposed in a line between the rotor and the mobile jaw in the open position.
摘要翻译： 蠕动泵（1）包括具有滚子的转子，具有打开位置和闭合位置的移动夹爪，并且还包括在转子的每一侧上的用于所述管的定位构件，其适于在被压入时将其接收 并且允许其在定位构件延伸的纵向方向上滑动，所述定位构件在打开位置中以转子和可动夹爪之间的线设置。
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