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公开(公告)号：US20100075338A1
公开(公告)日：2010-03-25
申请号：US12532596
申请日：2008-03-20
CPC分类号： G01N33/92 , G01N33/49 , G01N33/72 , G01N2333/904 , G01N2333/918
摘要： A method and apparatus to estimate the concentration of a target substance (e.g. Cholesterol or CRP) in the plasma component of awhole blood sample without the need to separate the red blood cells from the plasma prior to testing, thereby simplfying the design and construction of the test device. The invention achieves this by measuring the analyte under investigation in a time dependent (bio-/immuno-) chemical reaction and measuring separately, a marker substance (e.g haemoglobin) for the estimation of red blood cell volume, using a non-time-dependent alteration in physical property of the reaction mixture (in this instance, transmission) attributed to inherent filter effects on sample addition. These non-time- dependent changes are not part of the reaction chemistry, and are resolved from the time dependent alteration in physical property caused by the assay chemistry by continuous measurement and mathematical modelling. Algorithms that combine these two parameters are used to estimate the target substance and compensate for variations in the percentage haematocrit of the sample. The method equalises the assay response for subtle variations in patient sample (e.g. haematocrit).
摘要翻译： 一种评估血样中血浆成分中目标物质浓度（如胆固醇或CRP）的方法和装置，无需在测试前将红细胞与血浆分离，从而简化了 测试设备。 本发明通过在时间依赖（生物 - /免疫 - ）化学反应中测量被研究的分析物并分别测量用于估计红细胞体积的标记物质（例如血红蛋白），使用非时间依赖性 归因于固体过滤器对样品添加的影响的反应混合物（在这种情况下，透射）的物理性质的改变。 这些非时间依赖性变化不是反应化学的一部分，并且通过连续测量和数学建模从测定化学所引起的物理性质的时间依赖性变化中解决。 结合这两个参数的算法用于估计目标物质并补偿样品百分比红细胞比容的变化。 该方法使患者样品中细微变化的测定反应相等（例如血细胞比容）。
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公开(公告)号：US07943331B2
公开(公告)日：2011-05-17
申请号：US12532596
申请日：2008-03-20
CPC分类号： G01N33/92 , G01N33/49 , G01N33/72 , G01N2333/904 , G01N2333/918
摘要： A method and apparatus to estimate the concentration of a target substance (e.g. Cholesterol or CRP) in the plasma component of awhole blood sample without the need to separate the red blood cells from the plasma prior to testing, thereby simplfying the design and construction of the test device. The invention achieves this by measuring the analyte under investigation in a time dependent (bio-/immuno-) chemical reaction and measuring separately, a marker substance (e.g haemoglobin) for the estimation of red blood cell volume, using a non-time-dependent alteration in physical property of the reaction mixture (in this instance, transmission) attributed to inherent filter effects on sample addition. These non-time-dependent changes are not part of the reaction chemistry, and are resolved from the time dependent alteration in physical property caused by the assay chemistry by continuous measurement and mathematical modelling. Algorithms that combine these two parameters are used to estimate the target substance and compensate for variations in the percentage haematocrit of the sample. The method equalises the assay response for subtle variations in patient sample (e.g. haematocrit).
摘要翻译： 一种评估血样中血浆成分中目标物质浓度（如胆固醇或CRP）的方法和装置，无需在测试前将红细胞与血浆分离，从而简化了 测试设备。 本发明通过在时间依赖（生物 - /免疫 - ）化学反应中测量被研究的分析物并分别测量用于估计红细胞体积的标记物质（例如血红蛋白），使用非时间依赖性 归因于固体过滤器对样品添加的影响的反应混合物（在这种情况下，透射）的物理性质的改变。 这些非时间依赖性变化不是反应化学的一部分，并且通过连续测量和数学建模从测定化学所引起的物理性质的时间依赖性变化中解决。 结合这两个参数的算法用于估计目标物质并补偿样品百分比红细胞比容的变化。 该方法使患者样品中细微变化的测定反应相等（例如血细胞比容）。
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公开(公告)号：US07998742B2
公开(公告)日：2011-08-16
申请号：US12295575
申请日：2007-03-23
CPC分类号： G01N33/721 , G01N33/542
摘要： A method and apparatus to estimate the concentration of a non-fluorescent substance (e.g. haemoglobin) in a fluorescent assay by separately estimating the non time dependent alteration attributed to inherent filter effects from the time dependent alteration caused by the assay chemistry. Such a method obviates the requirement for a separate photometric or other measurement thereby simplifying the methodology and associated instrumentation.
摘要翻译： 通过分别估计归因于由测定化学引起的时间依赖性变化的固有滤波效应的非时间依赖性变化来估计荧光测定中的非荧光物质（例如血红蛋白）的浓度的方法和装置。 这种方法避免了单独的测光或其他测量的要求，从而简化了方法和相关仪器。
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公开(公告)号：US20090176309A1
公开(公告)日：2009-07-09
申请号：US12295575
申请日：2007-03-23
IPC分类号： G01N33/72
CPC分类号： G01N33/721 , G01N33/542
摘要： A method and apparatus to estimate the concentration of a non-fluorescent substance (e.g. haemoglobin) in a fluorescent assay by separately estimating the non time dependent alteration attributed to inherent filter effects from the time dependent alteration caused by the assay chemistry. Such a method obviates the requirement for a separate photometric or other measurement thereby simplifying the methodology and associated instrumentation.
摘要翻译： 通过分别估计归因于由测定化学引起的时间依赖性变化的固有滤波效应的非时间依赖性变化来估计荧光测定中的非荧光物质（例如血红蛋白）的浓度的方法和装置。 这种方法避免了单独的测光或其他测量的要求，从而简化了方法和相关仪器。
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