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    Whole Blood Assay
    1.
    发明申请
    Whole Blood Assay 有权
    全血分析

    公开(公告)号：US20100075338A1

    公开(公告)日：2010-03-25

    申请号：US12532596

    申请日：2008-03-20

    申请人： John Phillip Vessey ,  Adrian Richard Gray ,  David Percival

    发明人： John Phillip Vessey ,  Adrian Richard Gray ,  David Percival

    IPC分类号： G01N33/53 ,  C12Q1/02 ,  C12Q1/60

    CPC分类号： G01N33/92 ,  G01N33/49 ,  G01N33/72 ,  G01N2333/904 ,  G01N2333/918

    摘要： A method and apparatus to estimate the concentration of a target substance (e.g. Cholesterol or CRP) in the plasma component of awhole blood sample without the need to separate the red blood cells from the plasma prior to testing, thereby simplfying the design and construction of the test device. The invention achieves this by measuring the analyte under investigation in a time dependent (bio-/immuno-) chemical reaction and measuring separately, a marker substance (e.g haemoglobin) for the estimation of red blood cell volume, using a non-time-dependent alteration in physical property of the reaction mixture (in this instance, transmission) attributed to inherent filter effects on sample addition. These non-time- dependent changes are not part of the reaction chemistry, and are resolved from the time dependent alteration in physical property caused by the assay chemistry by continuous measurement and mathematical modelling. Algorithms that combine these two parameters are used to estimate the target substance and compensate for variations in the percentage haematocrit of the sample. The method equalises the assay response for subtle variations in patient sample (e.g. haematocrit).

    摘要翻译： 一种评估血样中血浆成分中目标物质浓度（如胆固醇或CRP）的方法和装置，无需在测试前将红细胞与血浆分离，从而简化了 测试设备。 本发明通过在时间依赖（生物 - /免疫 - ）化学反应中测量被研究的分析物并分别测量用于估计红细胞体积的标记物质（例如血红蛋白），使用非时间依赖性 归因于固体过滤器对样品添加的影响的反应混合物（在这种情况下，透射）的物理性质的改变。 这些非时间依赖性变化不是反应化学的一部分，并且通过连续测量和数学建模从测定化学所引起的物理性质的时间依赖性变化中解决。 结合这两个参数的算法用于估计目标物质并补偿样品百分比红细胞比容的变化。 该方法使患者样品中细微变化的测定反应相等（例如血细胞比容）。

    Whole blood assay
    2.
    发明授权
    Whole blood assay 有权
    全血检测

    公开(公告)号：US07943331B2

    公开(公告)日：2011-05-17

    申请号：US12532596

    申请日：2008-03-20

    申请人： John Phillip Vessey ,  Adrian Richard Gray ,  David Percival

    发明人： John Phillip Vessey ,  Adrian Richard Gray ,  David Percival

    IPC分类号： G01N31/00 ,  G01N33/53

    CPC分类号： G01N33/92 ,  G01N33/49 ,  G01N33/72 ,  G01N2333/904 ,  G01N2333/918

    摘要： A method and apparatus to estimate the concentration of a target substance (e.g. Cholesterol or CRP) in the plasma component of awhole blood sample without the need to separate the red blood cells from the plasma prior to testing, thereby simplfying the design and construction of the test device. The invention achieves this by measuring the analyte under investigation in a time dependent (bio-/immuno-) chemical reaction and measuring separately, a marker substance (e.g haemoglobin) for the estimation of red blood cell volume, using a non-time-dependent alteration in physical property of the reaction mixture (in this instance, transmission) attributed to inherent filter effects on sample addition. These non-time-dependent changes are not part of the reaction chemistry, and are resolved from the time dependent alteration in physical property caused by the assay chemistry by continuous measurement and mathematical modelling. Algorithms that combine these two parameters are used to estimate the target substance and compensate for variations in the percentage haematocrit of the sample. The method equalises the assay response for subtle variations in patient sample (e.g. haematocrit).

    摘要翻译： 一种评估血样中血浆成分中目标物质浓度（如胆固醇或CRP）的方法和装置，无需在测试前将红细胞与血浆分离，从而简化了 测试设备。 本发明通过在时间依赖（生物 - /免疫 - ）化学反应中测量被研究的分析物并分别测量用于估计红细胞体积的标记物质（例如血红蛋白），使用非时间依赖性 归因于固体过滤器对样品添加的影响的反应混合物（在这种情况下，透射）的物理性质的改变。 这些非时间依赖性变化不是反应化学的一部分，并且通过连续测量和数学建模从测定化学所引起的物理性质的时间依赖性变化中解决。 结合这两个参数的算法用于估计目标物质并补偿样品百分比红细胞比容的变化。 该方法使患者样品中细微变化的测定反应相等（例如血细胞比容）。

    Assay reagents and devices
    3.
    发明申请
    Assay reagents and devices 审中-公开
    测定试剂和装置

    公开(公告)号：US20070259446A1

    公开(公告)日：2007-11-08

    申请号：US11595820

    申请日：2006-11-09

    申请人： Yvonne Penfold ,  David Percival

    发明人： Yvonne Penfold ,  David Percival

    IPC分类号： G01N33/566

    CPC分类号： G01N33/54393 ,  G01N33/558 ,  G01N33/585 ,  Y10S435/805 ,  Y10S435/97 ,  Y10S436/81

    摘要： A reagent useful in immunoassays, comprising a direct particulate level co-sensitised with a specific binding agent having specificity for an analyte or analyte analogue and with a non-specific protein which can participate in a control reaction with another specific binding agent which does not bind to the first specific binding agent nor participate in the formation of a complex by means of which detection of the analyte or analyte analogue is accomplished. Preferably the first specific binding agent is an antibody raised in a first species and the non-specific protein is an immunoglobulin from another species. Optionally, the reagent additionally comprises a second population of the direct particulate label sensitised solely with the non-specific protein.

    摘要翻译： 可用于免疫测定的试剂，其包含与对分析物或分析物类似物具有特异性的特异性结合剂共同致敏的直接颗粒水平，以及可与不结合的另一特异性结合剂参与对照反应的非特异性蛋白质 至第一特异性结合剂，也不参与复合物的形成，通过该复合物检测分析物或分析物类似物。 优选地，第一特异性结合剂是在第一种中产生的抗体，非特异性蛋白是来自另一物种的免疫球蛋白。 任选地，试剂另外包含仅与非特异性蛋白质敏感的直接颗粒标签的第二群体。

    Spray nozzle
    4.
    发明申请
    Spray nozzle 有权
    喷嘴

    公开(公告)号：US20070235564A1

    公开(公告)日：2007-10-11

    申请号：US11580179

    申请日：2006-10-12

    申请人： Frank Whittaker ,  James Lloyd ,  David Percival

    发明人： Frank Whittaker ,  James Lloyd ,  David Percival

    IPC分类号： B05B1/34

    CPC分类号： B05B1/3442 ,  B05B1/00 ,  B05B15/18 ,  B05B15/65

    摘要： A spray nozzle (300) which employs a locking and an alignment feature (330) to facilitate the replacement of internal nozzle components. The spray nozzle includes a nozzle body (310), a swirl element (314) and an orifice disc (312). The nozzle body defines a central bore which extends between a fluid receiving section and a fluid discharge section and delineates a central axis and delimits an interior locating surface for swirl element and the orifice disc. The orifice disc includes a protuberance (374) associated with the downstream surface thereof which protrudes into the spray opening of the nozzle body.

    摘要翻译： 一种喷嘴（300），其采用锁定和对准特征（330）以便于更换内部喷嘴部件。 喷嘴包括喷嘴主体（310），涡流元件（314）和孔板（312）。 喷嘴主体限定了中心孔，该中心孔在流体接收部分和流体排出部分之间延伸并且描绘中心轴线并限定了旋转元件和孔板的内部定位表面。 孔盘包括与其下游表面相关联的突起（374），其突出到喷嘴体的喷雾开口中。