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    Process for the production of piperidine derivatives with microorganisms
    1.
    发明授权
    Process for the production of piperidine derivatives with microorganisms 有权
    用微生物生产哌啶衍生物的方法

    公开(公告)号：US07691615B2

    公开(公告)日：2010-04-06

    申请号：US11624096

    申请日：2007-01-17

    申请人： Peter C. Michels ,  Eric L. Zirbes

    发明人： Peter C. Michels ,  Eric L. Zirbes

    IPC分类号： C12P17/21

    CPC分类号： C12P17/12 ,  C07D211/46 ,  C07D211/70

    摘要： The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is —COOH or —COOR4; R4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy. This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB: wherein R3 is —CH3 and R1, R2, A, B, and D are defined above in the presence of a microorganism under conditions effective to produce the product compound. The microorganism can be from the genus Streptomyces, Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Pseudomonas, Helicostylum, Aspergillus, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, or Penicilluc. Alternatively, the microorganism can be Cunninghamella baineri.

    摘要翻译： 本发明涉及具有根据式IA和/或IB的结构的产物化合物的制备：其中n为0或1; R1是氢或羟基; R2是氢; 或者当n为0时，R 1和R 2一起形成带有R 1和R 2的碳原子之间的第二个键，条件是当n为1时，R 1和R 2各自为氢; R3为-COOH或-COOR4; R4是烷基或芳基部分; A，B和D是它们的环的取代基，其各自可以不同或相同，并且选自氢，卤素，烷基，羟基和烷氧基。 该方法包括孵育具有根据式IIA和/或IIB的结构的起始化合物：其中R 3是-CH 3，并且R 1，R 2，A，B和D如上所述在微生物存在下在有效产生 产品化合物。 微生物可以来自链霉菌属，茎状菌属，胶霉属，芽孢杆菌属，葡萄孢属，Cyathus，根霉，Pycniodosphora，假单胞菌属，Helicostylum，曲霉属，毛霉属，Gelasinospora，Rhodotorula，假丝酵母​​属，分枝杆菌属或Penicilluc。 或者，微生物可以是贝宁（Cunninghamella baineri）。

    Process for the production of piperidine derivatives with microorganisms
    4.
    发明授权
    Process for the production of piperidine derivatives with microorganisms 有权
    用微生物生产哌啶衍生物的方法

    公开(公告)号：US07232908B2

    公开(公告)日：2007-06-19

    申请号：US10638841

    申请日：2003-08-11

    申请人： Peter C. Michels ,  Eric L. Zirbes

    发明人： Peter C. Michels ,  Eric L. Zirbes

    IPC分类号： C07D211/22 ,  C12P17/12

    CPC分类号： C12P17/12 ,  C07D211/46 ,  C07D211/70

    摘要： The present invention relates to a process for the production of piperidine derivatives with microorganisms. This is carried out by incubating starting compounds in the presence of a microorganism under conditions effective to produce piperidine derivative products. Suitable microorganisms can be from any one of the genus of Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Pseudomonas, Helicostylum, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, and Penicillium. In another aspect of the invention, starting compounds are incubated in the presence of Cunninghamella bainieria under conditions effective to produce piperidine derivative products.

    摘要翻译： 本发明涉及用微生物生产哌啶衍生物的方法。 这通过在有效产生哌啶衍生物产物的条件下在微生物存在下温育起始化合物来进行。 合适的微生物可以来自任何一种属的Stemphylium，Gliocladium，Bacillus，Botrytis，Cyathus，Rhizopus，Pycniodosphora，Pseudomonas，Helicostylum，Mucor，Gelasinospora，Rhodotorula，Candida，Mycobacterium和Penicillium。 在本发明的另一方面，起始化合物在有效产生哌啶衍生物产物的条件下，在金银菌存在下孵育。

    Process for the production of piperidine derivatives with microorganisms
    5.
    发明授权
    Process for the production of piperidine derivatives with microorganisms 有权
    用微生物生产哌啶衍生物的方法

    公开(公告)号：US06613907B2

    公开(公告)日：2003-09-02

    申请号：US09754786

    申请日：2001-01-04

    申请人： Peter C. Michels ,  Eric L. Zirbes

    发明人： Peter C. Michels ,  Eric L. Zirbes

    IPC分类号： C07D21122

    CPC分类号： C12P17/12 ,  C07D211/46 ,  C07D211/70

    摘要： The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB: wherein n is 0 or 1; R1 is hydrogen or hydroxy; R2 is hydrogen; or, when n is 0, R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2, provided that when n is 1, R1 and R2 are each hydrogen; R3 is —COOH or —COOR4; R4 is an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy. This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB: wherein R3 is —CH3 and R1, R2, A, B, and D are defined above In the presence of a microorganism under conditions effective to produce the product compound. The microorganism can be from the genus Streptomyces, Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Psuedomonas, Helicostylum, Aspergillus, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, or Pennicillium. Alternatively, the microorganism can be Cunninghamella bainieri.

    摘要翻译： 本发明涉及具有根据式IA和/或IB的结构的产物化合物的制备：其中n为0或1; R 1为氢或羟基; R 2为氢;或当n为0时，R 1和R 2为 一起形成带有R1和R2的碳原子之间的第二个键，条件是当n为1时，R 1和R 2各自为氢; R 3为-COOH或-COOR 4; R 4为烷基或芳基; A，B和D 是它们的环的取代基，其各自可以不同或相同，并且选自氢，卤素，烷基，羟基和烷氧基。该方法包括孵育具有根据式IIA的结构的起始化合物 和/或IIB：其中R3是-CH3，R1，R2，A，B和D如上定义在有效产生产物化合物的条件下在微生物存在下。 微生物可以来自链霉菌属，腐霉属，胶霉属，芽孢杆菌属，Botrytis，Cyathus，Rhizopus，Pycniodosphora，Psuedomonas，Helicostylum，Aspergillus，Mucor，Gelasinospora，Rhodotorula，Candida，Mycobacterium或Pennicillium。 或者，微生物可以是贻贝（Cunninghamella bainieri）。

    Cyclosporins
    8.
    发明授权
    Cyclosporins 有权
    环孢菌素

    公开(公告)号：US07538084B2

    公开(公告)日：2009-05-26

    申请号：US10802013

    申请日：2004-03-16

    申请人： Bruce F. Molino ,  Simon N. Haydar ,  Zhicai Yang ,  Peter C. Michels ,  Michael S. Hemenway ,  Joseph O. Rich ,  Yuri Khmelnitsky

    发明人： Bruce F. Molino ,  Simon N. Haydar ,  Zhicai Yang ,  Peter C. Michels ,  Michael S. Hemenway ,  Joseph O. Rich ,  Yuri Khmelnitsky

    IPC分类号： A61K38/00

    CPC分类号： C07K7/645

    摘要： The compounds of the present invention are represented by the chemical structure found in Formula I: Formula I where A is an amino acid of Formula II: or a pharmaceutically acceptable salt thereof, with R0, R1, B, C, D, E, F, G, H, I, J, and K defined herein.

    摘要翻译： 本发明的化合物由式I中所示的化学结构表示：

    公式I 其中A是式II的氨基酸： 或其药学上可接受的盐与本文定义的R0，R1，B，C，D，E，F，G，H，I，J和K.