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    Treatment of Peyronies disease
    4.
    发明授权
    Treatment of Peyronies disease 有权
    治疗Peyronies病

    公开(公告)号：US09180172B2

    公开(公告)日：2015-11-10

    申请号：US13327450

    申请日：2011-12-15

    申请人： Natalie Ann Borgos

    发明人： Natalie Ann Borgos

    IPC分类号： C12N9/00 ,  A61K38/48 ,  A61K35/28

    CPC分类号： A61K38/4886 ,  A61K9/0019 ,  A61K9/0034 ,  A61K35/28 ,  A61K2300/00

    摘要： The invention relates to systems and therapeutic methods to reduce plaque causing Peyronie's disease. One approach uses high pressure injection of collagenase-containing composition into a penile plaque. Plaque disruption is enhanced by the mechanical force of the high pressure, followed by the enzymatic action of collagenase. Another approach uses collagenase as a pretreatment, followed by addition of adipose-derived stem cells ADSCs. The initial collagenase injection breaks down collagen (often more type III than type I in Peyronie's) to provide short term benefit. The longer-term benefit is provided by introduction of ADSCs to the plaque, which can produce cytokines and other signals for revascularization and restoration of normal penile tissue. The resulting combination advantageously reduces the bulk of the plaque early on with ongoing reduction through the revascularization of the tissue. In addition, the treatment provides an advantageous shift of elastin and collagen ratios.

    摘要翻译： 本发明涉及减少导致佩罗尼氏病的斑块的系统和治疗方法。 一种方法是使用高压注射含胶原酶的组合物进入阴茎斑块。 通过高压的机械力增强斑块破裂，接着是胶原酶的酶促作用。 另一种方法使用胶原酶作为预处理，然后加入脂肪来源的干细胞ADSC。 最初的胶原酶注射分解胶原蛋白（通常比Peyronie的III型比I型更多）以提供短期益处。 通过将ADSC引入斑块可以产生更长期的益处，其可以产生细胞因子和其他用于血管重建和恢复正常阴茎组织的信号。 所得到的组合有利地通过组织血运重建的进一步减少来早期减少斑块的体积。 此外，该治疗提供了弹性蛋白和胶原比例的有利变化。

    MICRO-NEEDLE BLADDER BALLOON
    5.
    发明申请
    MICRO-NEEDLE BLADDER BALLOON 审中-公开
    微针式气泡

    公开(公告)号：US20130331783A1

    公开(公告)日：2013-12-12

    申请号：US13993752

    申请日：2011-12-16

    申请人： Carrie Lee Herman ,  Natalie Ann Borgos ,  Kari L. Cierzan

    发明人： Carrie Lee Herman ,  Natalie Ann Borgos ,  Kari L. Cierzan

    IPC分类号： A61M25/10 ,  A61M37/00

    摘要： Devices and methods for delivering treatment fluids or particulates such as, stem cells, drugs, Botox and like, to an inner lining of a bladder for treatment of urinary tract disorders, including over active bladder. A balloon delivery system can include an inflation balloon having a plurality of micro-needles configured to pierce and otherwise puncture an inner bladder wall so as to deliver the treatment fluid to bladder tissue. The treatment fluid can be directly injected into the bladder tissue using the micro needles. Alternatively, the micro needles can be fabricated of bioabsorbable or bioresorbable materials such that the micro needles can remain embedded within the bladder tissue to deliver the treatment fluid or particulate.

    摘要翻译： 用于将处理液或诸如干细胞，药物，肉毒杆菌毒素等颗粒物质递送到膀胱内衬以治疗尿路疾病（包括过度膀胱）的装置和方法。 气囊输送系统可以包括具有多个微针的充气气囊，所述微针构造成刺穿或以其它方式刺穿内囊壁，以便将治疗流体输送到膀胱组织。 处理液可以使用微针直接注入膀胱组织。 或者，微针可以由生物可吸收或生物可吸收材料制成，使得微针可以保持嵌入在膀胱组织内以递送治疗流体或微粒。

    Micro-needle bladder balloon
    6.
    发明授权
    Micro-needle bladder balloon 有权

    公开(公告)号：US10589070B2

    公开(公告)日：2020-03-17

    申请号：US13993752

    申请日：2011-12-16

    申请人： Carrie Lee Herman ,  Natalie Ann Borgos ,  Kari L. Cierzan

    发明人： Carrie Lee Herman ,  Natalie Ann Borgos ,  Kari L. Cierzan

    IPC分类号： A61M25/10 ,  A61M37/00 ,  A61M31/00

    摘要： Devices and methods for delivering treatment fluids or particulates such as, stem cells, drugs, Botox and like, to an inner lining of a bladder for treatment of urinary tract disorders, including over active bladder. A balloon delivery system can include an inflation balloon having a plurality of micro-needles configured to pierce and otherwise puncture an inner bladder wall so as to deliver the treatment fluid to bladder tissue. The treatment fluid can be directly injected into the bladder tissue using the micro needles. Alternatively, the micro needles can be fabricated of bioabsorbable or bioresorbable materials such that the micro needles can remain embedded within the bladder tissue to deliver the treatment fluid or particulate.

    TREATMENT OF PELVIC FLOOR DISORDERS WITH AN ADIPOSE-DERIVED CELL COMPOSITION
    7.
    发明申请
    TREATMENT OF PELVIC FLOOR DISORDERS WITH AN ADIPOSE-DERIVED CELL COMPOSITION 审中-公开
    用ADIPOSE衍生细胞组合物治疗皮肤病患者的病症

    公开(公告)号：US20110008299A1

    公开(公告)日：2011-01-13

    申请号：US12920570

    申请日：2009-03-26

    申请人： Edouard A. Koullick ,  Tania M. Schroeder ,  Natalie Ann Borgos

    发明人： Edouard A. Koullick ,  Tania M. Schroeder ,  Natalie Ann Borgos

    IPC分类号： A61K35/12 ,  A61P15/00 ,  A61P13/10

    CPC分类号： C12N5/0653 ,  A61K35/12 ,  A61K2035/124

    摘要： A method for treating a pelvic floor disease comprises removing adipose tissue from a patient, processing a first portion of the adipose tissue to obtain a heterogeneous mixture of cells that includes adipose-derived stem cells, combining the heterogeneous mixture of cells with a second, unprocessed portion of the adipose tissue in a ratio of from approximately 1:1 to 1:4 to produce a cell composition, wherein the second portion of the adipose tissue is structured to provide a natural scaffold, and administering the cell composition to the patient to treat a pelvic floor disease.

    摘要翻译： 用于治疗盆底疾病的方法包括从患者中去除脂肪组织，加工脂肪组织的第一部分以获得包含脂肪来源的干细胞的细胞的不均匀混合物，将细胞的不均匀混合物与第二未加工的 部分脂肪组织的比例为约1:1至1:4以产生细胞组合物，其中脂肪组织的第二部分被构造成提供天然支架，并将该细胞组合物施用于患者以治疗 盆底疾病。

    TREATMENT OF PEYRONIES DISEASE
    8.
    发明申请
    TREATMENT OF PEYRONIES DISEASE 有权
    治疗爱滋病

    公开(公告)号：US20120156178A1

    公开(公告)日：2012-06-21

    申请号：US13327450

    申请日：2011-12-15

    申请人： Natalie Ann Borgos

    发明人： Natalie Ann Borgos

    IPC分类号： A61K35/12 ,  A61P15/00 ,  A61K38/48

    CPC分类号： A61K38/4886 ,  A61K9/0019 ,  A61K9/0034 ,  A61K35/28 ,  A61K2300/00

    摘要： The invention relates to systems and therapeutic methods to reduce plaque causing Peyronie's disease. One approach uses high pressure injection of collagenase-containing composition into a penile plaque. Plaque disruption is enhanced by the mechanical force of the high pressure, followed by the enzymatic action of collagenase. Another approach uses collagenase as a pretreatment, followed by addition of adipose-derived stem cells ADSCs. The initial collagenase injection breaks down collagen (often more type III than type I in Peyronie's) to provide short term benefit. The longer-term benefit is provided by introduction of ADSCs to the plaque, which can produce cytokines and other signals for revascularization and restoration of normal penile tissue. The resulting combination advantageously reduces the bulk of the plaque early on with ongoing reduction through the revascularization of the tissue. In addition, the treatment provides an advantageous shift of elastin and collagen ratios.

    摘要翻译： 本发明涉及减少导致佩罗尼氏病的斑块的系统和治疗方法。 一种方法是将含胶原酶组合物的高压注射用于阴茎斑块。 通过高压的机械力增强斑块破裂，接着是胶原酶的酶促作用。 另一种方法使用胶原酶作为预处理，然后加入脂肪来源的干细胞ADSC。 最初的胶原酶注射分解胶原蛋白（通常比Peyronie的III型比I型更多）以提供短期益处。 通过将ADSC引入斑块可以产生更长期的益处，其可以产生细胞因子和其他用于血管重建和恢复正常阴茎组织的信号。 所得到的组合有利地通过组织血运重建的进一步减少来早期减少斑块的体积。 此外，该治疗提供了弹性蛋白和胶原比例的有利变化。