公开(公告)号：US06760619B1

公开(公告)日：2004-07-06

申请号：US09945449

申请日：2001-08-31

申请人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

发明人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

IPC分类号： A61N1368

CPC分类号： A61N1/3627 ,  A61N1/3684 ,  A61N1/3918 ,  A61N1/395

摘要： An implantable cardiac stimulation system senses electrical activity of all four chambers of the heart and delivers pacing and defibrillation pulses to all four chambers of the heart. The system includes a lead system consisting of first and second leads. The first lead includes a right ventricular pacing electrode, a right ventricular defibrillation electrode, and a right atrial defibrillation lead. The second lead is implantable in the coronary sinus of the heart and includes a left ventricular pacing electrode, a left ventricular defibrillation electrode, a left atrial pacing electrode, and a left atrial defibrillation electrode. A right atrial pacing electrode is carried by one of the first and second leads. The system further includes a cardiac stimulation device including a pulse generator that delivers defibrillation pulses between any combination of the defibrillation electrodes and pacing pulses to any one of the pacing electrodes and a sensing circuit that senses cardiac electrical activity with any one of the pacing electrodes.

摘要翻译： 植入式心脏刺激系统感测心脏的所有四个腔室的电活动，并将心脏起搏和除颤脉冲输送到心脏的所有四个腔室。 该系统包括由第一和第二引线组成的引导系统。 第一个引线包括右心室起搏电极，右心室除颤电极和右心房除颤引线。 第二引线可植入心脏的冠状窦内，包括左心室起搏电极，左心室除颤电极，左心房起搏电极和左心房除颤电极。 右心房起搏电极由第一和第二引线之一承载。 该系统还包括心脏刺激装置，其包括脉冲发生器，该脉冲发生器将除颤电极和起搏脉冲的任何组合之间的除颤脉冲传送到任何一个起搏电极，以及感测电路，其用任何一个起搏电极感测心脏电活动。

公开(公告)号：US06748268B1

公开(公告)日：2004-06-08

申请号：US09945079

申请日：2001-08-31

申请人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

发明人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

IPC分类号： A61N1368

CPC分类号： A61N1/0563 ,  A61N1/3918 ,  A61N1/395 ,  A61N2001/0585

摘要： A three lead implantable cardiac stimulation system is capable of delivering stimulation pulses to any one chamber or combination of chambers of a heart. The system includes a first lead for implant in the right ventricle and having a right ventricular defibrillation electrode, a second lead for implant in the coronary sinus and having a left ventricular defibrillation electrode, and a third lead for implant in the coronary sinus and having a left atrial defibrillation electrode. One of the leads further including a right atrial defibrillation electrode for placement in one of the right atrium and superior vena cava. The system further includes an implantable cardiac stimulation device including a programmable pulse generator that delivers defibrillation pulses to any one of the defibrillation electrodes or to any combination of the defibrillation electrodes. The leads may further provide at least one pacing electrode for each chamber of the heart and the device is programmable to provide pacing pulses to any one of the pacing electrodes.

摘要翻译： 三引线可植入心脏刺激系统能够将刺激脉冲输送到心脏的任何一个腔室或腔室的组合。 该系统包括用于植入右心室并具有右心室除颤电极的第一引线，用于在冠状窦内植入并具有左心室除颤电极的第二引线和用于植入在冠状窦中的第三引线，并具有 左心房除颤电极。 其中一个引线还包括右心房除颤电极，用于放置在右心房和上腔静脉中的一个。 该系统还包括可植入心脏刺激装置，其包括将除颤脉冲输送到除颤电极中的任何一个或除颤电极的任何组合的可编程脉冲发生器。 引线还可以为心脏的每个腔室提供至少一个起搏电极，并且该装置可编程以将起搏脉冲提供给任何一个起搏电极。

公开(公告)号：US07881810B1

公开(公告)日：2011-02-01

申请号：US11753484

申请日：2007-05-24

申请人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

发明人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

IPC分类号： A61N1/05

CPC分类号： A61F2/2478 ,  A61B17/00 ,  A61B17/0057 ,  A61N1/0587

摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.

摘要翻译： 可以通过心脏的心包空间访问心脏的腔室或脉管系统。 最初，心包空间可以通过心肌的方法或亚型的方法进行。 因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。 铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

公开(公告)号：US06745081B1

公开(公告)日：2004-06-01

申请号：US09944683

申请日：2001-08-31

申请人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

发明人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

IPC分类号： A61N1372

CPC分类号： A61N1/056 ,  A61N1/3684 ,  A61N2001/0585

摘要： An implantable cardiac stimulation system including a single atrial dedicated lead provides sensing electrical activity of and delivering stimulation pulses to the right and left atria of the heart. The single lead is implantable in the coronary sinus of the heart and includes a distal left atrial pacing electrode, and a right atrial pacing electrode. The electrodes are spaced apart on the lead so that when the left atrial pacing electrode is in electrical contact with and adjacent the left atrium within the coronary sinus, the right atrial pacing electrode is in electrical contact with the right atrium and adjacent to the ostium of the coronary sinus within the coronary sinus. The system further includes an implantable cardiac stimulation device including a pulse generator and a sensing circuit that is coupled to the left and right pacing electrodes. They may further include one or more defibrillation coil electrodes.

摘要翻译： 包括单个心房专用线的可植入心脏刺激系统提供对心脏的右心房和左心房的感测电活动并将刺激脉冲递送给心脏。 单个引线可植入心脏的冠状窦，并且包括左心房起搏电极和右心房起搏电极。 电极在引线上间隔开，使得当左心房起搏电极与冠状窦内的左心房电接触并邻近时，右心房起搏电极与右心房电接触并邻近于 冠状窦内冠状窦内。 该系统还包括可植入心脏刺激装置，其包括脉冲发生器和耦合到左右起搏电极的感测电路。 它们还可以包括一个或多个除颤线圈电极。

公开(公告)号：US08538555B1

公开(公告)日：2013-09-17

申请号：US12973810

申请日：2010-12-20

申请人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

发明人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

IPC分类号： A61N1/00

CPC分类号： A61F2/2478 ,  A61B17/00 ,  A61B17/0057 ,  A61N1/0587

摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.

摘要翻译： 可以通过心脏的心包空间访问心脏的腔室或脉管系统。 最初，心包空间可以通过心肌的方法或亚型的方法进行。 因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。 铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

公开(公告)号：US08311648B1

公开(公告)日：2012-11-13

申请号：US12973800

申请日：2010-12-20

申请人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

发明人： Yougandh Chitre ,  Gene A. Bornzin ,  John R. Helland ,  Eric Falkenberg ,  Kevin L. Morgan ,  Sheldon Williams ,  Michael Yang ,  Andrew W. McGarvey

IPC分类号： A61N1/05

CPC分类号： A61F2/2478 ,  A61B17/00 ,  A61B17/0057 ,  A61N1/0587

摘要： A delivery apparatus for accessing the pericardial space of a heart including an elongated body defining a lumen and a piercing member that extends from a distal portion of the elongated body for piercing tissue of the heart. A spring expands from a distal end of the piercing member in response to the distal end of the piercing member passing through the tissue and into the pericardial space. An electrode located on the spring in order to sense signals indicative of a distal end of the spring passing through the tissue and into the pericardial space.

摘要翻译： 一种用于进入心脏的心包空间的输送装置，包括限定内腔的细长主体和从细长主体的远端部分延伸以刺穿心脏的组织的穿刺构件。 响应于刺穿构件的远端穿过组织并进入心包空间，弹簧从穿刺构件的远端膨胀。 位于弹簧上的电极，用于感测指示穿过组织并进入心包空间的弹簧的远端的信号。

公开(公告)号：US06721598B1

公开(公告)日：2004-04-13

申请号：US09945415

申请日：2001-08-31

申请人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

发明人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

IPC分类号： A61N118

CPC分类号： A61N1/056 ,  A61N1/0563 ,  A61N2001/0585

摘要： An implantable cardiac stimulation system and lead is capable of sensing electrical activity of the right and left heart and delivering stimulation pulses to the right and left heart. The system includes a single cardiac lead including a left ventricular pacing electrode, a left ventricular defibrillation electrode, a left atrial pacing electrode, a left atrial defibrillation electrode, and a right atrial pacing electrode. The system further includes a cardiac stimulation device including a pulse generator for delivering pacing pulses to any combination of the pacing electrodes, delivering defibrillation pulses to any combination of the defibrillation electrodes, and sensing electrical activity with any combination of the pacing electrodes. The lead is implantable in the coronary sinus of the heart and may further include a right atrial defibrillation coil electrode.

摘要翻译： 植入式心脏刺激系统和引线能够感测右心和左心的电活动，并将刺激脉冲输送到右心和左心。 该系统包括单心心脏导联，其包括左心室起搏电极，左心室除颤电极，左心房起搏电极，左心房除颤电极和右心房起搏电极。 该系统还包括心脏刺激装置，其包括用于将起搏脉冲发送到起搏电极的任何组合的脉冲发生器，将除颤脉冲输送到除颤电极的任何组合，以及用起搏电极的任何组合感测电活动。 铅可植入心脏的冠状窦，并可进一步包括右心房除颤线圈电极。

公开(公告)号：US06640136B1

公开(公告)日：2003-10-28

申请号：US09953458

申请日：2001-09-12

申请人： John R. Helland ,  Gene A. Bornzin

发明人： John R. Helland ,  Gene A. Bornzin

IPC分类号： A61N1368

CPC分类号： A61N1/3712 ,  A61N1/368 ,  A61N1/3714 ,  A61N1/3918

摘要： An implantable cardiac stimulation device in which cross-chamber stimulation is avoided. The present device is intended for use an implantable device that is intended to stimulate one or more cardiac chambers, for example, in a dual-chamber or multi-chamber device. According to one illustrative embodiment of the device, capture thresholds are determined for a first chamber that is intended to be captured, and also for a second chamber that is not intended to be captured. The stimulation energy is then set to a level based upon the respective capture thresholds.

摘要翻译： 一种植入式心脏刺激装置，其中避免了横室刺激。 本装置旨在使用旨在刺激一个或多个心室的可植入装置，例如在双室或多室装置中。 根据装置的一个说明性实施例，确定用于要被捕获的第一室的捕获阈值，以及对于不意图被捕获的第二室。 然后将刺激能量设置为基于相应捕获阈值的水平。

公开(公告)号：US07848821B1

公开(公告)日：2010-12-07

申请号：US11456825

申请日：2006-07-11

申请人： Kyungmoo Ryu ,  Gene A. Bornzin ,  John R. Helland

发明人： Kyungmoo Ryu ,  Gene A. Bornzin ,  John R. Helland

IPC分类号： A61N1/05

CPC分类号： A61N1/0573 ,  A61N1/0587 ,  A61N2001/058

摘要： What is described is a method of implanting one or more electrodes of a pacing or defibrillation lead in heart tissue. The method comprises positioning a distal end of a catheter against a surface of the heart tissue, extending a distal end of a first electrode from a lumen of the catheter such that the distal end of the first electrode penetrates the surface, and retracting the first electrode to fix a hook feature of the first electrode in the heart tissue.

摘要翻译： 所描述的是在心脏组织中植入起搏或除颤引线的一个或多个电极的方法。 该方法包括将导管的远端定位在心脏组织的表面上，使第一电极的远端从导管的内腔延伸，使得第一电极的远端穿透表面，并使第一电极回缩 以固定心脏组织中第一电极的钩特征。

公开(公告)号：US06988007B1

公开(公告)日：2006-01-17

申请号：US10218353

申请日：2002-08-13

申请人： Kevin L. Morgan ,  Gene A. Bornzin ,  Joseph J. Florio ,  John R. Helland

发明人： Kevin L. Morgan ,  Gene A. Bornzin ,  Joseph J. Florio ,  John R. Helland

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N2001/0585

摘要： An implantable single-pass cardiac stimulation lead provides for placement of electrodes into electrical contact with two chambers of a patient's heart. The lead includes an inner lead body having at least one electrode at its distal end and an outer lead body having at least one electrode at its distal end. The outer lead body has an internal lumen that slidingly receives the inner lead body. The inner lead body is extendable from the outer lead body at a point proximal to the distal end of the outer lead body. The sliding of the inner lead body relative to the outer lead body enables the inner lead body distal electrode to have a varying distance from the outer lead body distal electrode and enables the inner lead body to extend into the coronary sinus region of the heart to place the inner lead body electrode into electrical contact with the left ventricle.

摘要翻译： 可植入的单程心脏刺激引线提供将电极放置在与患者心脏的两个腔室电接触的位置。 引线包括在其远端具有至少一个电极的内引线体和在其远端具有至少一个电极的外引线体。 外引线体具有滑动地接收内引线体的内腔。 内引线体可以在外引线体的远离外引线体的远端的位置处延伸。 内引线体相对于外引线体的滑动能够使内引线体远端电极与外引线体远端电极间距离变化，能够使内引线体延伸到心脏的冠状窦区域 内部引线体电极与左心室电接触。