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    Subcutaneous implantable cardiac device system with low defibrillation thresholds and improved sensing
    4.
    发明授权
    Subcutaneous implantable cardiac device system with low defibrillation thresholds and improved sensing 有权
    具有低除颤阈值和改进感测的皮下植入式心脏装置系统

    公开(公告)号：US07925343B1

    公开(公告)日：2011-04-12

    申请号：US11539576

    申请日：2006-10-06

    申请人： Xiaoyi Min ,  Scott Salys ,  Yougandh Chitre ,  Eric Falkenberg ,  Gene A. Bornzin

    发明人： Xiaoyi Min ,  Scott Salys ,  Yougandh Chitre ,  Eric Falkenberg ,  Gene A. Bornzin

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3956 ,  A61B5/04014 ,  A61B5/046 ,  A61B5/7203 ,  A61N1/0563 ,  A61N1/37288

    摘要： A subcutaneous implantable cardiac device system applies defibrillation currents in pathways aligned with the heart's own electrical system to decrease defibrillation thresholds. In one implementation, one or more subcutaneous sensors detect ventricular fibrillation. Positioning of subcutaneous sensors and filtering result in improved sensing with reduced noise. A subcutaneous patch component of the system that is in communication with a subcutaneous pacemaker or cardioverter-defibrillator may perform the sensing and apply the defibrillation. The subcutaneous patch may include one or more electrodes that perform both sensing and defibrillation. Variations of the subcutaneous patch may include battery and capacitor for generating onboard defibrillation current and may also include a microprocessor for advanced programmable operation.

    摘要翻译： 皮下植入式心脏装置系统在与心脏自身的电气系统对准的途径中应用除颤电流以降低除颤阈值。 在一个实施方案中，一个或多个皮下传感器检测心室颤动。 皮下传感器的定位和过滤导致改进的感测，噪音降低。 与皮下起搏器或心律转复除颤器连通的系统的皮下补片部件可以执行感测并施加除颤。 皮下补片可以包括执行感测和除颤的一个或多个电极。 皮下贴片的变化可以包括用于产生板上除颤电流的电池和电容器，并且还可以包括用于高级可编程操作的微处理器。

    Two lead universal defibrillation, pacing and sensing system
    5.
    发明授权
    Two lead universal defibrillation, pacing and sensing system 失效
    双引线通用除颤，起搏和感应系统

    公开(公告)号：US06760619B1

    公开(公告)日：2004-07-06

    申请号：US09945449

    申请日：2001-08-31

    申请人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

    发明人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

    IPC分类号： A61N1368

    CPC分类号： A61N1/3627 ,  A61N1/3684 ,  A61N1/3918 ,  A61N1/395

    摘要： An implantable cardiac stimulation system senses electrical activity of all four chambers of the heart and delivers pacing and defibrillation pulses to all four chambers of the heart. The system includes a lead system consisting of first and second leads. The first lead includes a right ventricular pacing electrode, a right ventricular defibrillation electrode, and a right atrial defibrillation lead. The second lead is implantable in the coronary sinus of the heart and includes a left ventricular pacing electrode, a left ventricular defibrillation electrode, a left atrial pacing electrode, and a left atrial defibrillation electrode. A right atrial pacing electrode is carried by one of the first and second leads. The system further includes a cardiac stimulation device including a pulse generator that delivers defibrillation pulses between any combination of the defibrillation electrodes and pacing pulses to any one of the pacing electrodes and a sensing circuit that senses cardiac electrical activity with any one of the pacing electrodes.

    摘要翻译： 植入式心脏刺激系统感测心脏的所有四个腔室的电活动，并将心脏起搏和除颤脉冲输送到心脏的所有四个腔室。 该系统包括由第一和第二引线组成的引导系统。 第一个引线包括右心室起搏电极，右心室除颤电极和右心房除颤引线。 第二引线可植入心脏的冠状窦内，包括左心室起搏电极，左心室除颤电极，左心房起搏电极和左心房除颤电极。 右心房起搏电极由第一和第二引线之一承载。 该系统还包括心脏刺激装置，其包括脉冲发生器，该脉冲发生器将除颤电极和起搏脉冲的任何组合之间的除颤脉冲传送到任何一个起搏电极，以及感测电路，其用任何一个起搏电极感测心脏电活动。

    Three lead universal pacing and shocking system
    6.
    发明授权
    Three lead universal pacing and shocking system 失效
    三主控通用起搏和震动系统

    公开(公告)号：US06748268B1

    公开(公告)日：2004-06-08

    申请号：US09945079

    申请日：2001-08-31

    申请人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

    发明人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

    IPC分类号： A61N1368

    CPC分类号： A61N1/0563 ,  A61N1/3918 ,  A61N1/395 ,  A61N2001/0585

    摘要： A three lead implantable cardiac stimulation system is capable of delivering stimulation pulses to any one chamber or combination of chambers of a heart. The system includes a first lead for implant in the right ventricle and having a right ventricular defibrillation electrode, a second lead for implant in the coronary sinus and having a left ventricular defibrillation electrode, and a third lead for implant in the coronary sinus and having a left atrial defibrillation electrode. One of the leads further including a right atrial defibrillation electrode for placement in one of the right atrium and superior vena cava. The system further includes an implantable cardiac stimulation device including a programmable pulse generator that delivers defibrillation pulses to any one of the defibrillation electrodes or to any combination of the defibrillation electrodes. The leads may further provide at least one pacing electrode for each chamber of the heart and the device is programmable to provide pacing pulses to any one of the pacing electrodes.

    摘要翻译： 三引线可植入心脏刺激系统能够将刺激脉冲输送到心脏的任何一个腔室或腔室的组合。 该系统包括用于植入右心室并具有右心室除颤电极的第一引线，用于在冠状窦内植入并具有左心室除颤电极的第二引线和用于植入在冠状窦中的第三引线，并具有 左心房除颤电极。 其中一个引线还包括右心房除颤电极，用于放置在右心房和上腔静脉中的一个。 该系统还包括可植入心脏刺激装置，其包括将除颤脉冲输送到除颤电极中的任何一个或除颤电极的任何组合的可编程脉冲发生器。 引线还可以为心脏的每个腔室提供至少一个起搏电极，并且该装置可编程以将起搏脉冲提供给任何一个起搏电极。

    Coronary Sinus Cardiac Lead For Stimulating and Sensing The Atria of the Right and Left Heart and System
    7.
    发明授权
    Coronary Sinus Cardiac Lead For Stimulating and Sensing The Atria of the Right and Left Heart and System 有权
    冠状动脉窦心脏铅刺激和感应右心左心房系统

    公开(公告)号：US06745081B1

    公开(公告)日：2004-06-01

    申请号：US09944683

    申请日：2001-08-31

    申请人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

    发明人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

    IPC分类号： A61N1372

    CPC分类号： A61N1/056 ,  A61N1/3684 ,  A61N2001/0585

    摘要： An implantable cardiac stimulation system including a single atrial dedicated lead provides sensing electrical activity of and delivering stimulation pulses to the right and left atria of the heart. The single lead is implantable in the coronary sinus of the heart and includes a distal left atrial pacing electrode, and a right atrial pacing electrode. The electrodes are spaced apart on the lead so that when the left atrial pacing electrode is in electrical contact with and adjacent the left atrium within the coronary sinus, the right atrial pacing electrode is in electrical contact with the right atrium and adjacent to the ostium of the coronary sinus within the coronary sinus. The system further includes an implantable cardiac stimulation device including a pulse generator and a sensing circuit that is coupled to the left and right pacing electrodes. They may further include one or more defibrillation coil electrodes.

    摘要翻译： 包括单个心房专用线的可植入心脏刺激系统提供对心脏的右心房和左心房的感测电活动并将刺激脉冲递送给心脏。 单个引线可植入心脏的冠状窦，并且包括左心房起搏电极和右心房起搏电极。 电极在引线上间隔开，使得当左心房起搏电极与冠状窦内的左心房电接触并邻近时，右心房起搏电极与右心房电接触并邻近于 冠状窦内冠状窦内。 该系统还包括可植入心脏刺激装置，其包括脉冲发生器和耦合到左右起搏电极的感测电路。 它们还可以包括一个或多个除颤线圈电极。

    Coronary sinus cardiac lead for stimulating and sensing in the right and left heart and system
    8.
    发明授权
    Coronary sinus cardiac lead for stimulating and sensing in the right and left heart and system 失效
    冠状窦心脏引导用于左右心脏和系统的刺激和感测

    公开(公告)号：US06721598B1

    公开(公告)日：2004-04-13

    申请号：US09945415

    申请日：2001-08-31

    申请人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

    发明人： John R. Helland ,  Gene A. Bornzin ,  Eric Falkenberg

    IPC分类号： A61N118

    CPC分类号： A61N1/056 ,  A61N1/0563 ,  A61N2001/0585

    摘要： An implantable cardiac stimulation system and lead is capable of sensing electrical activity of the right and left heart and delivering stimulation pulses to the right and left heart. The system includes a single cardiac lead including a left ventricular pacing electrode, a left ventricular defibrillation electrode, a left atrial pacing electrode, a left atrial defibrillation electrode, and a right atrial pacing electrode. The system further includes a cardiac stimulation device including a pulse generator for delivering pacing pulses to any combination of the pacing electrodes, delivering defibrillation pulses to any combination of the defibrillation electrodes, and sensing electrical activity with any combination of the pacing electrodes. The lead is implantable in the coronary sinus of the heart and may further include a right atrial defibrillation coil electrode.

    摘要翻译： 植入式心脏刺激系统和引线能够感测右心和左心的电活动，并将刺激脉冲输送到右心和左心。 该系统包括单心心脏导联，其包括左心室起搏电极，左心室除颤电极，左心房起搏电极，左心房除颤电极和右心房起搏电极。 该系统还包括心脏刺激装置，其包括用于将起搏脉冲发送到起搏电极的任何组合的脉冲发生器，将除颤脉冲输送到除颤电极的任何组合，以及用起搏电极的任何组合感测电活动。 铅可植入心脏的冠状窦，并可进一步包括右心房除颤线圈电极。

    Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method
    9.
    发明授权
    Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
    皮下心脏刺激装置提供抗心动过速起搏治疗和方法

    公开(公告)号：US07386342B1

    公开(公告)日：2008-06-10

    申请号：US10937756

    申请日：2004-09-08

    申请人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

    发明人： Eric Falkenberg ,  Mark W. Kroll ,  Gene A. Bornzin

    IPC分类号： A61N1/368

    CPC分类号： A61N1/0504 ,  A61N1/3622 ,  A61N1/37252

    摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

    摘要翻译： 植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。 该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。 起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

    Method and apparatus for dynamically adjusting overdrive pacing parameters
    10.
    发明授权
    Method and apparatus for dynamically adjusting overdrive pacing parameters 失效
    动态调整超速起搏参数的方法和装置

    公开(公告)号：US06904317B2

    公开(公告)日：2005-06-07

    申请号：US10043472

    申请日：2002-01-09

    申请人： Joseph J. Florio ,  Gene A. Bornzin ,  Peter Boileau ,  Eric Falkenberg ,  Janice Barstad

    发明人： Joseph J. Florio ,  Gene A. Bornzin ,  Peter Boileau ,  Eric Falkenberg ,  Janice Barstad

    IPC分类号： A61N1/362 ,  A61N1/36

    CPC分类号： A61N1/3621

    摘要： Dynamic overdrive pacing adjustment techniques are described for use in implantable cardiac stimulation devices. In a first technique, an overdrive pacing unit of a microcontroller of the implantable device operates to optimize various control parameters that affect overdrive pacing so as to achieve a desired degree of overdrive pacing for the particular patient in which the stimulation device is implanted. Parameters to be optimized include the number of overdrive beats paced once overdrive pacing is trigged, the overdrive pacing response function, the recovery rate, and various base rates. The control parameters are adjusted in a hierarchical order of priority until the desired degree of overdrive pacing is achieved. Adjustment of the number of overdrive beats, the recovery rate, and various base rates is iteratively performed by using incremental numerical adjustments. Adjustment of the overdrive pacing response function may be performed by selecting among a set of fixed predetermined linear response functions. In a second technique, the overdrive pacing unit operates to optimize the shape of a single non-linear dynamic overdrive pacing response function so as to achieve the desired degree of overdrive pacing for the patient. The second technique may either be employed alone or in combination with the first, hierarchical optimization technique.

    摘要翻译： 动态超速起搏调节技术被描述用于可植入心脏刺激装置。 在第一技术中，可植入装置的微控制器的过驱动起搏单元操作以优化影响过驱动起搏的各种控制参数，以便为其中植入刺激装置的特定患者达到期望程度的过速起搏。 要优化的参数包括一旦超速起搏起搏起搏，超速起搏响应功能，恢复速率和各种基准速率起搏的过载跳动次数。 控制参数以优先级的等级顺序进行调整，直到达到期望的过速起搏程度。 通过使用增量数值调整迭代地执行过载跳动次数的调整，恢复率和各种基本速率。 可以通过在一组固定的预定线性响应函数中进行选择来执行过速起搏响应功能的调整。 在第二种技术中，超速起搏单元操作以优化单个非线性动态超速起搏响应功能的形状，以便达到病人期望程度的超速起搏起搏。 第二种技术可以单独使用，也可以与第一层级优化技术结合使用。