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    STIMULATION OF SATIETY HORMONE RELEASE
    5.
    发明申请
    STIMULATION OF SATIETY HORMONE RELEASE 审中-公开
    刺激激素释放激素

    公开(公告)号：US20130035559A1

    公开(公告)日：2013-02-07

    申请号：US13464470

    申请日：2012-05-04

    申请人： Pamela J. Hornby ,  Tatiana Ort ,  Radhika Kajekar ,  Paul R. Wade

    发明人： Pamela J. Hornby ,  Tatiana Ort ,  Radhika Kajekar ,  Paul R. Wade

    IPC分类号： A61M37/00 ,  A61B5/145 ,  A61B5/05

    CPC分类号： A61N1/36007

    摘要： The present invention provides a site specific way to enhance a natural hormonal response to nutrients entering the small intestine after gastric emptying, thereby providing therapeutic value for obesity or diabetic patients. In one aspect, the present invention provides methods of stimulating the release of satiety hormone in a subject comprising applying a first electrical stimulus to a tissue in the lumen of the gastrointestinal system of the subject contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus. The present invention also provides methods for predicting patient response to a weight loss surgery comprising applying a first electrical stimulus to a tissue of the gastrointestinal system of said patient contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus, assessing the effect of the electrical stimulus in said patient, and, correlating said effect to said patient's response to a weight loss surgery.

    摘要翻译： 本发明提供了一种在胃排空后增强对进入小肠的营养物的天然激素反应的位点特异性方法，从而为肥胖症或糖尿病患者提供治疗价值。 一方面，本发明提供刺激受试者中饱腹感激素释放的方法，其包括将第一次电刺激施用于受试者的胃肠系统的内腔中的组织，同时使组织的L细胞与 营养刺激。 本发明还提供了用于预测患者对减肥手术的反应的方法，其包括将所述患者的胃肠系统的组织同时与组织的L细胞接触营养刺激施加第一电刺激，评估效果 的所述患者的电刺激，并且将所述效果与所述患者对减肥手术的反应相关联。

    Stimulation of Satiety Hormone Release
    6.
    发明申请
    Stimulation of Satiety Hormone Release 审中-公开
    刺激饱和激素释放

    公开(公告)号：US20100056948A1

    公开(公告)日：2010-03-04

    申请号：US12546721

    申请日：2009-08-25

    申请人： Pamela J. Hornby ,  Tatiana Ort ,  Radhika Kajekar ,  Paul R. Wade

    发明人： Pamela J. Hornby ,  Tatiana Ort ,  Radhika Kajekar ,  Paul R. Wade

    IPC分类号： A61N1/36 ,  G01N33/53 ,  A61B5/05

    CPC分类号： A61N1/36007

    摘要： The present invention provides, among other things, a site specific way to enhance a natural hormonal response to nutrients entering the small intestine after gastric emptying, thereby providing therapeutic value for obesity or diabetic patients. In one aspect, the present invention provides methods of stimulating the release of satiety hormone in a subject comprising applying a first electrical stimulus to a tissue in the lumen of the gastrointestinal system of the subject contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus. In another aspect, the present invention provides methods for predicting patient response to a weight loss surgery comprising applying a first electrical stimulus to a tissue of the gastrointestinal system of said patient contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus, assessing the effect of the electrical stimulus in said patient, and, correlating said effect to said patient's response to a weight loss surgery.

    摘要翻译： 本发明尤其提供了一种在胃排空后增强对进入小肠的营养物的天然激素反应的位点特异性方法，从而为肥胖症或糖尿病患者提供治疗价值。 在一个方面，本发明提供刺激受试者中饱腹感激素释放的方法，包括将第一次电刺激施用于患者的胃肠系统的内腔中的组织，同时使组织的L细胞与 营养刺激。 另一方面，本发明提供了用于预测患者对减肥手术的反应的方法，该方法包括：将第一电刺激与所述患者的胃肠系统的组织同时与组织的L细胞与营养刺激物接触， 评估所述患者的电刺激的影响，以及将所述效果与所述患者对减肥手术的反应相关联。