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公开(公告)号：US20070238691A1
公开(公告)日：2007-10-11
申请号：US11727748
申请日：2007-03-28
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , C12N15/1132 , C12N2310/11 , C12N2310/14 , C12N2740/16211
摘要： The present invention relates to methods of inhibiting the replication of the HIV virus by providing siRNA or antisense polynucleotides of eIF-5A1. The present invention also provides methods of inhibiting expression of p24 with siRNA or antisense polynucleotides of eIF-5A1.
摘要翻译： 本发明涉及通过提供eIF-5A1的siRNA或反义多核苷酸来抑制HIV病毒复制的方法。 本发明还提供了用eIF-5A1的siRNA或反义多核苷酸抑制p24表达的方法。
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2.发明申请Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNA as anti-inflammatory therapeutics 审中-公开用反义寡核苷酸和siRNA作为抗炎治疗剂抑制凋亡特异性eIF-5A（“eIF-5A1”）公开(公告)号：US20060094677A1
公开(公告)日：2006-05-04
申请号：US11134445
申请日：2005-05-23
申请人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
发明人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFKB by inhibiting expression of apoptosis-specific eIF-5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡特异性eIF-5A或eIF5A1，核酸和多肽，以及使用反义核苷酸或siRNA抑制或抑制细胞凋亡以抑制表达的方法 的凋亡特异性eIF-5A。 本发明还涉及通过抑制凋亡特异性eIF-5A的表达来抑制或抑制促炎细胞因子的表达或抑制NFκB的活化。
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3.发明申请Inhibition of apoptosis-specific eIF-5A ("eIF-5A1") with antisense oligonucleotides and siRNA as anti-inflammatory therapeutics 审中-公开用反义寡核苷酸和siRNA作为抗炎治疗剂抑制凋亡特异性eIF-5A（“eIF-5A1”）公开(公告)号：US20100168047A9
公开(公告)日：2010-07-01
申请号：US11134445
申请日：2005-05-23
申请人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
发明人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFKB by inhibiting expression of apoptosis-specific eIF-5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡特异性eIF-5A或eIF5A1，核酸和多肽，以及使用反义核苷酸或siRNA抑制或抑制细胞凋亡以抑制表达的方法 的凋亡特异性eIF-5A。 本发明还涉及通过抑制凋亡特异性eIF-5A的表达来抑制或抑制促炎细胞因子的表达或抑制NFκB的活化。
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公开(公告)号：US20060287265A1
公开(公告)日：2006-12-21
申请号：US11293391
申请日：2005-12-05
申请人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
发明人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
CPC分类号： C07K14/4747 , A61K48/00
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for increasing or decreasing expression of apoptosis-specific eIF-5A. The invention also relates to methods of increasing or decreasing apoptosis.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡特异性eIF-5A或eIF5-A1核酸和多肽，以及用于增加或减少凋亡特异性eIF-5A表达的方法。 本发明还涉及增加或减少凋亡的方法。
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5.发明申请Use of apoptosis-specific eIF-5A siRNAs and antisense polynucleotides to inhibit/suppress an inflammatory response 审中-公开使用凋亡特异性eIF-5A siRNA和反义多核苷酸抑制/抑制炎性反应公开(公告)号：US20060154887A1
公开(公告)日：2006-07-13
申请号：US11184982
申请日：2005-07-20
申请人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
发明人： John Thompson , Bruce Galton , Catherine Taylor , Charles Dinarello , Leonid Reznikov , Adrienne Boone , Marianne Hopkins
CPC分类号： C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），被称为凋亡特异性eIF-5A或eIF5-A1核酸和多肽，以及使用反义核苷酸或siRNA对细胞凋亡抑制或抑制凋亡的方法 抑制凋亡特异性eIF-5A的表达。 本发明还涉及通过抑制细胞凋亡特异性eIF-5A的表达来抑制或抑制促炎细胞因子的表达或抑制NFkB的活化。
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6.发明申请Novel method of protecting islet cells from apoptosis during the donor harvesting process 审中-公开在供体采集过程中保护胰岛细胞免于凋亡的新方法公开(公告)号：US20080076728A1
公开(公告)日：2008-03-27
申请号：US11725470
申请日：2007-03-20
申请人： John Thompson , Charles Dinarello
发明人： John Thompson , Charles Dinarello
IPC分类号： A61K31/7088 , A61P43/00
CPC分类号： C12N15/113 , A61K31/7088 , C07K14/4705 , C12N5/0676 , C12N2310/14
摘要： The present invention relates to methods for improving the viability and recovery of islets that are separated from a donor organ for subsequent transplantation and more particularly relates to the use of eIF-5A1 siRNAs to enhance the viability of islets.
摘要翻译： 本发明涉及用于改善与用于随后移植的供体器官分离的胰岛的活力和恢复的方法，更具体地涉及eIF-5A1 siRNA用于增强胰岛活力的用途。
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7.发明申请Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1 失效使用反义寡核苷酸或siRNA抑制eIF-5A1的表达公开(公告)号：US20060178330A1
公开(公告)日：2006-08-10
申请号：US11287460
申请日：2005-11-28
申请人： John Thompson , Bruce Galton , Catherine Taylor , Adrienne Boone , Elizabeth Helkkila , Dominic Cliche , Shelley Culp-Stewart , John Flanagan , Michelle Senchyna
发明人： John Thompson , Bruce Galton , Catherine Taylor , Adrienne Boone , Elizabeth Helkkila , Dominic Cliche , Shelley Culp-Stewart , John Flanagan , Michelle Senchyna
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/11 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
摘要翻译： 本发明涉及凋亡特异性真核起始因子5A（eIF-5A），称为凋亡因子5A1或简单因子5A1，凋亡因子5A1核酸和多肽，以及使用反义核苷酸或siRNA至少抑制或抑制细胞凋亡的方法 抑制因子5A1的表达。 本发明还涉及通过抑制凋亡因子5A的表达抑制或抑制促炎细胞因子的表达。
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公开(公告)号：US20070154457A1
公开(公告)日：2007-07-05
申请号：US11637835
申请日：2006-12-13
申请人： John Thompson , Catherine Taylor
发明人： John Thompson , Catherine Taylor
IPC分类号： A61K48/00 , A61K9/127 , A61K31/787
CPC分类号： A61K38/1709 , A61K9/0019 , A61K31/787 , A61K48/0033 , A61K48/0041 , A61K48/005
摘要： The present invention relates to eucaryotic initiation factor 5A and the use of polynucleotides encoding the same to inhibit cancer cell growth and inhibit metastases. In a preferred embodiment, eIF-5A1 is used to kill multiple myeloma cells.
摘要翻译： 本发明涉及真核引发因子5A及其编码的多核苷酸用于抑制癌细胞生长和抑制转移的用途。 在优选的实施方案中，eIF-5A1用于杀死多发性骨髓瘤细胞。
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9.发明申请Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis 失效核酸，多肽，组合物和调节凋亡的方法公开(公告)号：US20070059831A1
公开(公告)日：2007-03-15
申请号：US11595990
申请日：2006-11-13
申请人： Catherine Taylor , Tzann-Wei Wang , Larry Petrov , John Carlson , Richard Narayansingh , Marianne Kaup , Dominic Cliche , John Thompson
发明人： Catherine Taylor , Tzann-Wei Wang , Larry Petrov , John Carlson , Richard Narayansingh , Marianne Kaup , Dominic Cliche , John Thompson
IPC分类号： C12N15/86
CPC分类号： C07K14/4747 , C12N9/0004 , C12Q1/6876 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.
摘要翻译： 本发明涉及分离和/或纯化的大鼠凋亡特异性真核启动因子5A（eIF-5A）和脱氧螺旋体合成酶（DHS）核酸和多肽。 本发明还涉及使用凋亡特异性eIF-5A和DHS调节凋亡的方法，以及用于这些方法的反义寡核苷酸和凋亡特异性eIF-5A和DHS的表达载体。
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公开(公告)号：US20210170127A1
公开(公告)日：2021-06-10
申请号：US17180990
申请日：2021-02-22
摘要： An umbrella-like scraper for cleaning tubes and pipes may include a scraper, an actuator and a hinge configured for selective deployment of the scraper by manipulation of the actuator.
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