公开(公告)号：US20090086908A1

公开(公告)日：2009-04-02

申请号：US12196300

申请日：2008-08-22

申请人： John William Harder ,  David L. Patton ,  Shiying Zheng ,  Ruizheng Wang ,  Joseph Francis Bringley ,  Douglas Lincoln Vizard ,  William E. McLaughlin ,  Heidi Hall ,  Mark E. Bridges

发明人： John William Harder ,  David L. Patton ,  Shiying Zheng ,  Ruizheng Wang ,  Joseph Francis Bringley ,  Douglas Lincoln Vizard ,  William E. McLaughlin ,  Heidi Hall ,  Mark E. Bridges

IPC分类号： G01N23/04 ,  G03B42/02

CPC分类号： A61B6/00 ,  A61B5/0035 ,  A61B5/0059 ,  A61B6/4216 ,  A61B6/4417 ,  A61B6/481 ,  A61B6/508 ,  A61B2503/40 ,  A61B2562/0242

摘要： An apparatus for multimodal imaging of an object includes a support stage for receiving an object to be imaged; an object supported on the stage, the object having been treated with a biocompatible imaging probe comprising nanoparticles carrying one or more targeting moieties and one or more diagnostic components for enabling capture of images of the object; a light source for producing a beam to illuminate the object; a filter positioned to receive and pass the beam toward the object; and a lens and camera system for capturing an image of the object. The apparatus may include a tiltable filter for filtering light from the source. The apparatus may include a mechanism for selectively directing light from the light source through a first filter assembly to produce a first beam of light of a first frequency range for illuminating an object on the stage in a first imaging mode or through a second filter assembly to produce a second beam of light of a second frequency range for illuminating an object on the stage in a second imaging mode, so that the lens and camera system captures light from the object illuminated by either the first or second beam of light to produce a first image in response to the first beam and a second image, different from the first image, in response to the second image. An x-ray source and phosphor plate may be included to provide an additional imaging mode.

摘要翻译： 用于物体的多模式成像的装置包括用于接收待成像对象的支撑台; 支撑在舞台上的物体，已经用生物相容性成像探针处理了物体，所述生物相容性成像探针包含携带一个或多个靶向部分的纳米颗粒和一个或多个诊断部件，用于能够捕获物体的图像; 用于产生用于照射物体的光束的光源; 定位成接收并将光束传递到物体的过滤器; 以及用于捕获对象的图像的镜头和相机系统。 该装置可以包括用于过滤来自源的光的可倾斜滤光器。 该装置可以包括用于选择性地引导来自光源的光通过第一滤光器组件以产生第一频率范围的第一光束的机构，用于以第一成像模式照射舞台上的物体或通过第二滤光器组件 产生第二频率范围的第二光束，用于在第二成像模式下照射舞台上的物体，使得透镜和照相机系统捕获来自被第一或第二光束照射的物体的光，以产生第一 响应于第一光束的图像和与第一图像不同的第二图像。 可以包括x射线源和磷光体板以提供附加的成像模式。